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Research Lab Results for HAND

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  • Haughey Lab: Neurodegenerative and Neuroinfectious Disease

    Lab Website

    Dr. Haughey directs a disease-oriented research program that address questions in basic neurobi...ology, and clinical neurology. The primary research interests of the laboratory are:

    1. To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
    2. To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitability.
    3. To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
    4. To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
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    Research Areas: multiple sclerosis, PTSD, HAND, HIV
  • Janet Record Lab

    Research in the Janet Record Lab focuses on medical education and patient-centered care. We’re ...currently developing a curriculum for internal medicine residents in the inpatient general medicine service setting. The curriculum teaches residents to use hand-carried ultrasound for imaging the inferior vena cava to assess volume status. view more

    Research Areas: medical education, patient-centered health care, imaging, internal medicine, inferior vena cava
  • JHU NIMH Research Center

    Lab Website

    The Johns Hopkins NIMH Center is comprised of an interdisciplinary research team who has pooled... their talents to study the nature of HIV-associated neurocognitive disorders (HAND). Their aim is to translate discoveries of the pathophysiological mechanisms into novel therapeutics for HAND.Our objectives are to integrate aspects of ongoing research in HAND and SIV encephalitis; to develop high-throughput and screening assays for identifying novel therapeutic compounds; to use proteomics and lipidomics approaches to indentifying surrogate markers of disease activity; to disseminate information and education about HAND through existing and new educational systems, including the JHU AIDS Education Training Center and the JHU Center for Global Clinical Education and to facilitate the entry of new investigators into neuro-AIDS research, and to catalyze new areas of research, particularly where relevant for drug discovery or the development of validated surrogate markers. view more

    Research Areas: neuropathy, HAND, AIDS dementia complex, myopathy, myelopathy, HIV-associated neurocognitive disorders
  • Johns Hopkins NIMH Center for Novel Therapeutics of HIV-associated Cognitive Disorders

    Lab Website

    The Johns Hopkins NIMH Center for Novel Therapeutics of HIV-associated Cognitive Disorders is a...n interdisciplinary team of researchers who work together to study the nature of HIV-association neurocognitive disorders (HAND). The goal of their research is to translate discoveries of the pathophysiological mechanisms into new therapies for HAND. view more

    Research Areas: cognition, HIV, neurocognitive disorders
  • Laboratory of Vestibular NeuroAdaptation

    Principal Investigator:
    Michael Schubert, Ph.D.
    Surgical Pathology
    Vein Centers

    The Laboratory of Vestibular NeuroAdaptation investigates mechanisms of gaze stability in peopl...e with loss of vestibular sensation. A bulk of our research investigates motor learning in the vestibulo-ocular reflex (VOR) using different types of error signals. In addition, we investigate the synergistic relationship between the vestibular and saccadic oculomotor systems as trainable strategies for gaze stability. We are particularly interested in developing novel technologies to assess and deliver improved rehabilitation outcomes. We are validating a hand-held computer tablet for assessment of sensorimotor function and participating in a clinical trial comparing traditional vestibular rehabilitation against a device developed in our laboratory that can unilaterally or bilaterally strengthen the VOR.

    Members of the lab include physical therapists, physicians, engineers, statisticians and post-doctoral fellows. The laboratory is supported by generous grant funding from NASA, the NIH, the DOD and grateful patients
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    Research Areas: gaze stability, vestibular sensation, vestibulo-ocular reflex, rehabilitation, sensorimotor functions
  • Motion Analysis Laboratory

    Lab Website

    Our team is focused on understanding how complex movements are normally learned and controlled,... and how damage to specific brain areas impairs these processes. We employ several techniques to quantify movement including: 3-dimensional tracking and reconstruction of movement, recordings of muscle activity, force plate recordings, and calculation of joint forces and torques. These techniques allow for very precise measurements of many different types of movements including: walking, reaching, leg movements, hand movements and standing balance. All studies are designed to test specific hypotheses about the function of different brain areas, the cause of specific impairments and/or the effects of different interventions. view more

    Research Areas: cerebellar function, neurological diseases, motor learning
  • Ocular Motor Physiology Laboratory

    Lab Website
    Principal Investigator:
    David Zee, M.D.
    Vein Centers

    Our research is directed toward how the brain controls the movements of the eyes (including eye... movements induced by head motion) using studies in normal human beings, patients and experimental animals. The focus is on mechanisms underlying adaptive ocular motor control. More specifically, what are mechanisms by which the brain learns to cope with the changes associated with normal development and aging as well as the damage associated with disease and trauma? How does the brain keep its eye movement reflexes properly calibrated? Our research strategy is to make accurate, quantitative measures of eye movements in response to precisely controlled stimuli and then use the analytical techniques of the control systems engineer to interpret the findings.

    Research areas: 1) learning and compensation for vestibular disturbances that occur either within the labyrinth or more centrally within the brain, 2) the mechanisms by which the brain maintains correct alignment of the eyes to prevent diplopia and strabismus, and 3) the role of ocular proprioception in localizing objects in space for accurate eye-hand coordination.
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    Research Areas: diplopia, Labyrinth, eye movement, strabismus, vestibular
  • The Vascularized Composite Allotransplantation (VCA) Research Lab

    Lab Website

    The Vascularized Composite Allotransplantation (VCA) Research Lab is leading research aimed at ...warding against rejection and reducing the number of medications patients have to take for the rest of their lives. They’re testing a protocol that involves treating the patient with antibodies on the day of transplant, followed by a donor bone marrow infusion several days later. This protocol would allow patients to be treated with low doses of a single maintenance drug after being transplanted. view more

    Research Areas: hand and arm transplant, penile transplant, face transplant, immunosuppression, reconstructive transplant, vascularized composite allotransplantation
  • Timothy Niessen Lab

    The Timothy Niessen Lab studies patient outcomes in the ICU. We are particularly interested in ...the effects of sleep quality, delirium transitions and sedation on the improvement of intensive care patients. Our investigators also focus on the practices of internal medicine interns, studying the variability of hand washing hygiene, etiquette-based communication and time spent in direct and indirect patient care. We have also studied the onset of myelopathy as a result of B12 deficiency from long-term colchicine treatment and recreational nitrous oxide use. view more

    Research Areas: medical education, safety, delirium, ICU, sedation
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