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  • Cammarato Lab

    Lab Website
    Principal Investigator:
    Anthony Cammarato, Ph.D.
    Medicine

    The Cammarato Lab is located in the Division of Cardiology in the Department of Medicine at the... Johns Hopkins University School of Medicine. We are interested in basic mechanisms of striated muscle biology.

    We employ an array of imaging techniques to study “structural physiology” of cardiac and skeletal muscle. Drosophila melanogaster, the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. We investigate conserved myopathic (muscle disease) processes and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself.

    Anthony Ross Cammarato, MD, is an assistant professor of medicine in the Cardiology Department. He studies the identification and manipulation of age- and mutation-dependent modifiers of cardiac function, hierarchical modeling and imaging of contractile machinery, integrative analysis of striated muscle performance and myopathic processes.
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    Research Areas: muscle development, genetics, myopathic processes, striated muscle biology, muscle function, myopathy, muscle physiology
  • Cardiac Surgery Research Lab

    Lab Website
    Principal Investigator:
    Jennifer Lawton, M.D.
    Medicine
    Surgery

    Founded in 1942 by surgeon Alfred Blalock and surgical technician Vivien Thomas, the Cardiac Su...rgery Research Lab at The Johns Hopkins Hospital serves not only to spearhead discovery and innovation in cardiothoracic surgery, but also to train future leaders in the field. Active areas of investigation include the development of novel, nanoparticle-based therapeutics to mitigate acute lung injury, avoid neurological injury during cardiac surgery, and improve organ preservation during heart and lung transplantation. The lab is also active in a variety of clinical research projects aimed at improving outcomes for our patients.

    Equally important, the lab plays a critical role in training residents for impactful careers in academic cardiothoracic surgery. Medical students, residents, and fellows receive hands-on simulation experiences to hone surgical skills outside of the operating room. The lab also serves as a training ground to develop research and investigation skills as trainees learn methods of advanced statistical analysis and academic writing. Special programs for undergraduates and medical students help develop their passion for cardiac surgery and surgical research, giving unique opportunities to young talent.
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    Research Areas: cardiac surgery, nanotechnology, cardiothoracic surgery, surgical models, heart transplant, lung transplant
  • Cardiology Bioengineering Laboratory

    Lab Website
    Principal Investigator:
    Henry Halperin, M.D.
    Medicine

    The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the... applications of advanced imaging techniques for arrhythmia management. The primary limitation of current fluoroscopy-guided techniques for ablation of cardiac arrhythmia is the inability to visualize soft tissues and 3-dimensional anatomic relationships.

    Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visualizing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation.

    Active projects include
    • Physiological differences between isolated hearts in ventricular fibrillation and pulseless electrical activity
    • Successful ablation sites in ischemic ventricular tachycardia in a porcine model and the correlation to magnetic resonance imaging (MRI)
    • MRI-guided radiofrequency ablation of canine atrial fibrillation, and diagnosis and intervention for arrhythmias
    • Physiological and metabolic effects of interruptions in chest compressions during cardiopulmonary resuscitation

    Henry Halperin, MD, is co-director of the Johns Hopkins Imaging Institute of Excellence and a
    professor of medicine, radiology and biomedical engineering. Menekhem M. Zviman, PhD is the laboratory manager.
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    Research Areas: magnetic resonance imaging, CPR models, cardiac mechanics, MRI-guided therapy, ischemic tachycardia, arrhythmia, cardiology, sudden cardiac death, cardiopulmonary resuscitation, computational modeling
  • Cardio-Obstetrics Research

    Lab Website

    Under the division of Maternal-Fetal Medicine, our Cardio-Obstetric research efforts seek to ad...vance the field of gynecology through medical care and innovation. With a focus on the effect of heart conditions on pregnancy and the ways in which pregnancy can put stress on your heart and circulatory system, our goal in this multi-disciplinary research is that our findings may lead to the development of new treatments or preventative therapies for patients and their babies to better manage a heart condition during pregnancy. view more

    Research Areas: heart conditions during pregnancy, heart conditions on pregnancy
  • Cardiovascular Analytical Intelligence Initiative (CV-Ai2)

    Lab Website
    Principal Investigator:
    Cedric Manlhiot, Ph.D.
    Medicine
    Pediatrics

    Among the hundreds of predictive models developed for cardiovascular disease, less than one-ten...th of 1% actually end up routinely used in clinical practice. CV-Ai2 uses data from clinical practice and analytic intelligence to solve clinical problems and create solutions that can be applied in real-world patient care. view more

    Research Areas: cardiovascular diseases
  • Cardiovascular Stem Cell Program

    Lab Website
    Principal Investigator:
    Chulan Kwon, Ph.D., M.S.
    Medicine

    The research program aims to advance cardiovascular biology and medicine by focusing on pluripo...tent stem cell-based modeling and therapy and by nurturing future leaders in regenerative medicine. view more

    Research Areas: cardiac, stem cells, cardiology, regenerative medicine
  • Caren L. Freel Meyers Laboratory

    Lab Website

    The long-term goal of the Caren L. Freel Meyers Laboratory is to develop novel approaches to ki...ll human pathogens, including bacterial pathogens and malaria parasites, with the ultimate objective of developing potential therapeutic agents.

    Toward this goal, we are pursuing studies of bacterial isoprenoid biosynthetic enzymes comprising the methylerythritol phosphate (MEP) pathway essential in many human pathogens. Studies focus on understanding mechanism and regulation in the pathway toward the development of selective inhibitors of isoprenoid biosynthesis. Our strategies for creating new anti-infective agents involve interdisciplinary research in the continuum of organic, biological and medicinal chemistry. Molecular biology, protein expression and biochemistry, and synthetic chemistry are key tools for our research.
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    Research Areas: bacterial pathogens, biochemistry, enzymes, infectious disease, protein expression, synthetic chemistry, isoprenoid biosynthesis, malaria, pharmacology, chemistry, molecular biology
  • Carey Research Group

    John Carey’s Research Group conducts research regarding diseases of the inner ear that affect b...oth balance and hearing mechanisms. Key interests include superior semicircular canal dehiscence syndrome (SCDS), the normal vestibular reflexes and how they change with age, novel intratympanic treatments (i.e., middle ear injections) for conditions like Menière’s disease and sudden hearing loss, and the mechanisms of vestibular migraine. With Lloyd Minor, Dr. Carey helped develop the operation to repair the superior canal in patients with SCDS using image-guided surgery. Dr. Carey has been funded by the National Institutes of Health – National Institute on Deafness and Other Communication Disorders to study inner ear balance function in Menière’s disease and steroid treatment of sudden hearing loss. view more

    Research Areas: meniere's disease, vertigo, audiology, neurotology/otology, superior canal dehiscence, cochlear implant, hearing loss
  • Carlo Colantuoni Laboratory

    Dr. Colantuoni and his colleagues explore human brain development and molecular mechanisms that... give rise to risk for complex brain disease. His team uses genomic technologies to examine human brain tissue as well as stem models and vast public data resources. view more

    Research Areas: stem cells, brain tissue, brain development, genomics
  • Casey Overby Lab

    Principal Investigator:
    Casey Taylor, Ph.D.
    Medicine

    Research in the Casey Overby Lab focuses on the intersection of public health genomics and biom...edical informatics. We’re currently developing applications to support the translation of genomic research to clinical and population-based health care settings. We’re also working to develop knowledge-based ways to use big data — including electronic health records — to improve population health. view more

    Research Areas: public health, genomics, electronic health records, bioinformatics
  • Center for Bioengineering Innovation and Design

    Lab Website

    The Center for Bioengineering Innovation and Design educates and develops the next generation o...f leaders in health care technology innovation. CBID creates and develops solutions for major challenges to human health around the world. Our key measure of success is the positive impact of our students and their solutions on the quality and accessibility of health care worldwide. view more

    Research Areas: health care technology, bionegineering, education
  • Center for Epithelial Disorders

    Principal Investigator:
    Mark Donowitz, M.D.
    Medicine
    Physiology

    The Johns Hopkins Center for Epithelial Disorders focuses on research into the physiology and p...athophysiology of epithelial cells (cells that line the cavities and interior surfaces of the body) of the gastrointestinal (GI) tract, liver, pancreas and kidney. Specifically, the center’s research seeks to:

    -Understand the mechanisms regulating the activity of transport proteins (including channels) of epithelial cells
    Characterize the mechanisms by which polarity of epithelial cells are maintained
    -Investigate the mechanisms controlling transcription of epithelial-specific genes
    Understand the pathophysiological basis of GI and renal diseases that involve the preceding three components
    -The center also provides a framework for training fellows in gastroenterology and hepatology to become independent investigators.

    The center is funded primarily through individual investigator-initiated extramural research grant support from the National Institutes of Health (NIH) as well as multi-investigator grants including RO1, PO1, UO1 and R24.
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    Research Areas: gastroenterology, epithelial cells
  • Center for Infection and Inflammation Imaging Research

    Lab Website
    Principal Investigator:
    Sanjay Jain, M.B.B.S., M.D.
    Medicine

    In conjunction with the Molecular Imaging Center, the Center for Infection and Inflammation Ima...ging Research core provides state-of-the art small animal imaging equipment, including PET, SPECT, CT and US, to support the wide range of scientific projects within the diverse research community of the Johns Hopkins University and beyond. Trained technologists assist investigators in the use of these facilities. view more

    Research Areas: infectious disease, imaging, inflammation
  • Center for Nanomedicine

    Lab Website
    Principal Investigator:
    Justin Hanes, Ph.D.
    Ophthalmology

    The Center for Nanomedicine engineers drug and gene delivery technologies that have significant... implications for the prevention, treatment and cure of many major diseases facing the world today. Specifically, we are focusing on the eye, central nervous system, respiratory system, women's health, gastrointestinal system, cancer, and inflammation.

    We are a unique translational nanotechnology effort located that brings together engineers, scientists and clinicians working under one roof on translation of novel drug and gene delivery technologies
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    Research Areas: central nervous system, respiratory system, nanotechnology, cancer, drugs, women's health, inflammation, eye, gastrointestinal
  • Center for Research on Cardiac Intermediate Filaments

    Lab Website
    Principal Investigator:
    Giulio Agnetti, Ph.D.
    Medicine

    The CRCIF was established to foster collaborative efforts aimed at elucidating the role of inte...rmediate filaments (IFs) in the heart. Intermediate filaments constitute a class of cytoskeletal proteins in metazoan cells, however, different from actin microfilaments and tubulin microtubules, their function in cardiac cells is poorly understood. Unique from the other two components of the cytoskeleton, IFs are formed by cell type-specific proteins. Desmin is the main component of the IFs in the cardiac myocytes. We measured the consistent induction of desmin post-translational modifications (PTMs, such as phosphorylation, etc.) in various clinical and experimental models of heart failure. Therefore, one of our main focuses is to determine the contribution of desmin PTMs to the development of heart failure in different animal and clinical models.

    Active Projects:

    • Quantification of desmin PTM-forms in different forms of heart failure at the peptide level using mass spectrometry
    • Functional assessment of the role of desmin PTMs in heart failure development using single site mutagenesis and biophysical methods
    • Molecular characterization of desmin preamyloid oligomers using mass spectrometry, in vitro and in vivo imaging
    • Assessment of the diagnostic and pharmacological value of desmin PTMs in heart failure development
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    Research Areas: heart failure, intermediate filaments
  • Center on Aging and Health

    Lab Website
    Principal Investigator:
    David Roth, Ph.D., M.A.
    Medicine

    The Center on Aging and Health pursues creative approaches to solve the important health and he...alth care problems for an aging population. Research in our center involves population-based and clinical studies of the causes, correlates, and consequences of aging-related conditions, including frailty, disability, and social isolation. We house four distinct research working groups: the Frailty and Multisystem Dysregulation Working Group; the Family and Social Resources Working Group; the Cognitive and Sensory Functions Working Group; and the Biostatistics, Design and Analysis Working Group. We provide key infrastructure, such as the statistical data core, that supports clinical- and population-based research and education with expertise in research with older adults. view more

    Research Areas: cognition, disabilities, behavioral research, stroke, frailty, biostatistics, dementia, gerontology
  • Cervical Cancer Research Lab

    Lab Website

    Johns Hopkins is a member of the Specialized Program of Research Excellence (SPORE) in Cervical... Cancer. With a $11.5 million grant from the National Cancer Institute, we are conducting lab, translational and clinical studies to prevent and treat cervical cancers. Previous studies have identified connections between immune system genes and HPV16. Current projects include the development of next-generation HPV vaccines to control HPV-associated precursor lesions and invasive cancer. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: HPV vaccines, cervical cancer, HPV
  • Cervical Dysplasia Research Lab

    Lab Website

    We are interested in how immune responses occur in the cervix. The focus of our translational ...research is on developing immune therapies for disease caused by human papillomavirus (HPV). HPV infection causes more cancers than any other virus in the world. Cervical cancer is the most common cancer caused by HPV, and although we have known how to screen for it for over half a century, it remains the second most common cause of cancer death in women. Although the preventive vaccines are a public health milestone, they prevent HPV infections, but are not designed to make immune responses to treat HPV. We are testing different strategies to make immune responses that could treat HPV disease. Our dedicated researchers are working to extend the techniques used in HPV vaccine development to the creation of vaccines targeting other cancers with defined tumor antigens. view more

    Research Areas: cervical cancer, HPV, cancer vaccines
  • Charles Locke Lab

    Principal Investigator:
    Charles Locke, M.D.
    Medicine

    Research in the Charles Locke Lab focuses on the use and management of clinical resources in th...e evaluation and treatment of venous thromboembolic disease. view more

    Research Areas: venous thromboembolic disease, resource management
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