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  • Bowditch Research Group

    Lab Website

    Bowditch Research Group conducts research regarding speech discrimination in background noise, ...cochlear implants and osseointegrated hearing devices view more

    Research Areas: implantable technology, audiology, cochlear implant, hearing loss, hearing aids
  • Bradford Winters Lab

    The Bradford Winters Lab conducts research on patient safety and quality of care. Our team focu...ses on the topics of patient care in the intensive care unit, evidence-based medicine, quality health care, and the measurement and evaluation of safety efforts. Currently our work involves evaluating pain management techniques in post-craniotomy patients, developing guidelines for policy development of patient safety initiatives and creating measures for rapid-response system outcomes. view more

    Research Areas: patient safety, ICU, evidence-based medicine, quality of care
  • Bradley Undem Lab

    Principal Investigator:
    Bradley Undem, Ph.D.
    Medicine

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous sys...tem is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies. view more

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system
  • Brain Cancer Biology and Therapy Lab

    Lab Website
    Principal Investigator:
    Gregory Riggins, M.D., Ph.D.
    Neurosurgery

    The goal of the Johns Hopkins Brain Cancer Biology and Therapy Laboratory is to locate the gene...tic and genomic changes that lead to brain cancer. These molecular changes are evaluated for their potential as therapeutic targets and are often mutated genes, or genes that are over-expressed during the development of a brain cancer. The brain cancers that the Riggins Laboratory studies are medulloblastomas and glioblastomas. Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. Our laboratory uses large-scale genomic approaches to locate and analyze the genes that are mutated during brain cancer development. The technologies we now employ are capable of searching nearly all of a cancer genome for molecular alterations that can lead to cancer. The new molecular targets for cancer therapy are first located by large scale gene expression analysis, whole-genome scans for altered gene copy number and high throughput sequence analysis of cancer genomes. The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. view more

    Research Areas: brain cancer
  • Brain Science Institute (BSi)

    Lab Website
    Principal Investigator:
    Jeffrey Rothstein, M.D., Ph.D.
    Neurology

    The Brain Science Institute (BSi) brings together both basic and clinical neuroscientists from ...across the Johns Hopkins campuses. The BSi represents one of the largest and most diverse groups in the university. The BSi's mission is to solve fundamental questions about brain development and function and to use these insights to understand the mechanisms of brain disease. This new knowledge will provide the catalyst for the facilitation and development of effective therapies. The goals of our research are to foster new programs in basic neuroscience discovery; initiate a translational research program that will develop new treatments for brain-based diseases; and encourage collaboration, interdisciplinary teams, and new thinking that will have a global influence on research and treatment of the nervous system. view more

    Research Areas: brain, neuroscience, neurology, nervous system
  • Brain Tumor Cancer Genetics Lab

    Lab Website

    The lab explores the genetic underpinnings that drive the pathogenesis of a variety of primary ...central nervous system neoplasms. We are interested in exploiting genetic changes for both diagnostic and therapeutic purposes. Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. view more

    Research Areas: brain tumor genetics, brain tumor
  • Brain Tumor Laboratory

    Lab Website
    Principal Investigator:
    Henry Brem, M.D.
    Neurology
    Neurosurgery

    At the brain tumor laboratory, Henry Brem, M.D. and Betty Tyler, along with more than 350 train...ees, have conducted scientific research, contributed to scientific literature, amended clinical practice, and illuminated new pathways for improving clinical outcomes.



    The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors.
    view more

    Research Areas: brain tumor drug delivery, brain tumor
  • Braunstein Lab

    Lab Website
    Principal Investigator:
    Evan Braunstein, M.D., Ph.D.
    Medicine

    Dr. Braunstein's research focuses on inherited predisposition to hematologic diseases. His labo...ratory studies the inherited genetic changes in DNA that increase susceptibility to disease. Blood cancers such as myeloproliferative neoplasms and myelodysplastic syndromes are traditionally thought to be acquired disorders, however there is increasing evidence that inherited genetic changes play a role. In addition, Dr. Braunstein studies non-malignant blood diseases including atypical hemolytic uremic syndrome (aHUS) and related thrombotic disorders such as APLS, TTP and HELLP syndrome which are caused in part by genetic mutations. His work has identified a germline variants in the ERBB genes that predispose to hematologic malignancies. In addition, his research group found that patients with catastrophic APLS and HELLP syndrome frequently harbor germline mutations in complement regulatory genes. This has led directly to clinical trials designed to test the efficacy of complement inhibition in patients with these disorders. Dr. Braunstein continues to work toward translating the scientific findings from the laboratory into improved care and treatment for patients. view more

    Research Areas: Myeloproliferative neoplasms, complement disorders
  • Brendan Cormack Laboratory

    The Brendan Cormack Laboratory studies fungal pathogenesis, particularly the host-pathogen inte...raction for the yeast pathogen Candida glabrata.

    We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. We also screen mutants directly in mice for those unable to colonize or persist in the normal target organs (liver, kidney and spleen).

    We also focus research on a family of genes--the EPA genes--that allow the organism to bind to host cells. Our research shows that a subset of them are able to mediate adherence to host epithelial cells. We are trying to understand the contribution of this family to virulence in C. glabrata by figuring out what the ligand specificity is of different family members, how genes are normally regulated during infection, and what mechanisms normally act to keep the genes transcriptionally silent and how that silence is regulated.
    view more

    Research Areas: candida glabrata, pathogenesis, virulence genes, yeast, molecular biology
  • Brendan J. Canning Lab

    Principal Investigator:
    Brendan Canning, Ph.D.
    Medicine

    Research in the Brendan J. Canning Lab is focused on mechanistic studies of the cough reflex. T...hrough our work, we identified the afferent nerves that play an essential role in regulating cough. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. We have identified key sites of integration of airway afferent nerve input and mechanisms by which afferent nerve subtypes act synergistically to regulate cough. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry. view more

    Research Areas: airway reflexes, coughs, immunohistochemistry
  • Brennen Lab

    Principal Investigator:
    W. Nathaniel Brennen, Ph.D.
    Oncology

    The Brennen laboratory takes a rigorous, multi-disciplinary, team-based approach towards develo...ping innovative therapeutic and prognostic strategies for prostate cancer with an emphasis on exploiting vulnerabilities within the tumor microenvironment towards this goal. To accomplish this goal, we are strategically pursuing novel therapeutic platforms, including stromal-targeted prodrugs, protoxins, and radiolabeled antibodies, in addition to cell-based therapy and drug delivery; all of which are designed to reduce toxicity to peripheral non-target tissue (i.e. side effects) while maximizing anti-tumor efficacy (i.e. therapeutic benefit). Currently, many of these strategies are focused on overcoming stromal barriers to anti-tumor immune responses such that men suffering from prostate cancer can share in the immense, revolutionary power of immunotherapy that is transforming care for many with advanced disease in other tumor types previously thought to be unmanageable using conventional approaches. Unfortunately, prostate cancer has largely proven refractory to these powerful approaches thus far and requires novel mono- or combinatorial treatment strategies to unleash the full potential of the immune system and generate personalized anti-tumor responses with the capability of producing long-term durable responses or even cures in these men. view more

    Research Areas: prostate cancer, prodrugs, cell-based therapy, tumor microenvironment
  • Brent Petty Lab

    Lab Website
    Principal Investigator:
    Brent Petty, M.D.
    Medicine

    Dr. Petty's laboratory interests focuses on antimicrobial chemotherapy, hospital-based medical ...practices, and internal medicine collaboration with ophthalmologic clinical trials. view more

    Research Areas: cancer therapies, chemotherapy, patient-centered health care, hospital-based medical practices, cancer, internal medicine
  • Brian Garibaldi Lab

    Principal Investigator:
    Brian Garibaldi, M.D.
    Medicine

    Research in the Brian Garibaldi Lab focuses on acute lung injury (ALI) resolution. Recently, we... evaluated the mechanisms underlying mobility therapy and found that therapeutic exercise reduces neutrophilic lung injury and skeletal muscle wasting in ALI mice. view more

    Research Areas: pulmonary medicine, acute lung injury
  • Brindusa Truta Lab

    Principal Investigator:
    Brindusa Truta, M.D., M.A.S.
    Medicine

    The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ul...cerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history. view more

    Research Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis
  • Brown Lab

    Lab Website
    Principal Investigator:
    Solange Brown, M.D., Ph.D.
    Neuroscience

    The Brown Lab is focused on the function of the cerebral cortex in the brain, which underlies o...ur ability to interact with our environment through sensory perception and voluntary movement. Our research takes a bottom-up approach to understanding how the circuits of this massively interconnected network of neurons are functionally organized, and how dysfunction in these circuits contributes to neurodegenerative diseases like amyotrophic lateral sclerosis and neuropsychiatric disorders, including autism and schizophrenia. By combining electrophysiological and optogenetic approaches with anatomical and genetic techniques for identifying cell populations and pathways, the Brown Lab is defining the synaptic interactions among different classes of cortical neurons and determining how long-range and local inputs are integrated within cortical circuits. In amyotrophic lateral sclerosis, corticospinal and spinal motor neurons progressively degenerate. The Brown Lab is examining how abnormal activity within cortical circuits contributes to the selective degeneration of corticospinal motor neurons in an effort to identify new mechanisms for treating this disease. Abnormalities in the organization of cortical circuits and synapses have been identified in genetic and anatomical studies of neuropsychiatric disease. We are interested in the impact these abnormalities have on cortical processing and their contribution to the disordered cognition typical of autism and schizophrenia. view more

    Research Areas: autism, neurodegenerative diseases, brain, electrophysiology, ALS, schizophrenia, cerebral cortex, optogenetics
  • Bruce Leff Lab

    Principal Investigator:
    Bruce Leff, M.D.
    Medicine

    Research interests in the Bruce Leff Lab include home hospital, guided care, medical education ...and long-term care. view more

    Research Areas: medical education, gerontology, home hospital
  • C. John Sperati Lab

    Principal Investigator:
    C. John Sperati, M.D., M.H.S.
    Medicine

    Dr. Sperati’s group focuses on complement mediated kidney disorders, glomerular disease, and re...nal arterial disease secondary to fibromuscular dysplasia. His team has a particular interest in thrombotic microangiopathies involving the complement system. view more

    Research Areas: kidney diseases, fibromuscular dysplasia, hypertension, hyperaldosteronism, atherosclerosis
  • Caleb Alexander Lab

    Lab Website
    Principal Investigator:
    G. Alexander, M.D.
    Medicine

    Research in the Caleb Alexander Lab examines prescription drug use. This includes studies of po...pulation-based patterns and determinants of pharmaceutical use, clinical decision-making about prescription drugs, and the effect of changes in regulatory and payment policies on pharmaceutical utilization. We have special expertise in conducting survey-based studies and analyzing secondary data sources, including administrative claims, the Medical Expenditure Panel Survey and the National Ambulatory Medical Care Survey. view more

    Research Areas: epidemiology, medical decision making, drug safety, patient-provider relationships, pharmacoepidemiology, drugs
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