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  • Antoine Azar Lab

    Principal Investigator:
    Antoine Azar, M.D.
    Medicine

    The Antoine Azar Lab conducts research on topics related to primary immunodeficiency diseases, ...allergies and lung disease. Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma. view more

    Research Areas: emphysema, immunology, asthma, allergies, lung disease, COPD
  • Antony Rosen Lab

    Principal Investigator:
    Antony Rosen, M.B.Ch.B., M.S.
    Medicine

    Research in the Antony Rosen Lab investigates the mechanisms shared by the autoimmune rheumatic... diseases such as lupus, myositis, rheumatoid arthritis, scleroderma and SjogrenÕs syndrome. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. Our recent research has sought to define the traits of autoantibodies that enable them to induce cellular or molecular dysfunction. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer. view more

    Research Areas: myositis, lupus, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases, rheumatoid arthritis
  • Ari Cedars Laboratory

    Principal Investigator:
    Ari Cedars, M.D.
    Medicine

    Ari Cedars, M.D., and his team have three primary research goals. First, the Cedars Lab is inte...rested in patient-centered outcomes in congenital heart disease, which they investigate using a digital tracking system to record participants’ symptoms and quality of life. Second, the Cedars Lab investigates outcomes with mechanical circulatory support and transplant in congenital heart disease, with a focus on those with end-stage heart disease and a Fontan circulation. Third, the Cedars Lab is interested in the biological mechanisms underlying circulatory deterioration and end-organ dysfunction in patients with a Fontan circulation. view more

    Research Areas: heart disease, congenital heart disease
  • Ariel Green Lab

    Research in the Ariel Green Lab focuses on informing and improving decisions surrounding the us...e of invasive medical technologies for older adults with complex medical diseases. Our long-term goals are to conduct epidemiologic research, create public health initiatives, and help shape policies that improve the lives of older adults. view more

    Research Areas: epidemiology, health care policy, decision making, gerontology
  • Arturo Casadevall Lab

    The Arturo Casadevall Lab uses a multidisciplinary approach to explore two key topics within mi...crobiology and immunology: how microbes cause disease and how hosts can protect themselves against those microbes. Much of our research focuses on the fungus Cryptococcus neoformans, which frequently causes lung infections in people with impaired immunity. We also work with the microorganism Bacillus anthracis, a bacterium that causes anthrax and is frequently used in biological warfare. Our goal is to devise antibody-based countermeasures to protect against this and other similar threats. view more

    Research Areas: microbiology, immunology, vaccines, cryptococcus neoformans, tuberculosis
  • Ashish Nimgoankar Lab

    The Ashish Nimgoankar Lab is interested in translational technology development and image-guide...d therapies. view more

    Research Areas: translational technology, imaging
  • Athir Morad Lab

    Lab Website

    Research in the Athir Morad Lab primarily focuses on perioperative pain management for neurosur...gery patients. Our team has conducted two randomized controlled trials to assess the efficacy of patient-controlled analgesia (PCA) following craniotomy. Our current research includes studies on the safety of opioid administration following craniotomy through the use of end-tidal CO2 detection, as well as research into the use of transcortical magnetic stimulation (TMS) for managing pain after spine surgery. view more

    Research Areas: neurosurgery, opioids, spine, anesthesiology, pain
  • Auditory Brainstem Laboratory

    Lab Website

    The overall goal of the Auditory Brainstem Library is to understand how abnormal auditory input... from the ear affects the brainstem, and how the brain in turn affects activity in the ear through efferent feedback loops. Our emphasis is on understanding the effects of different forms of acquired hearing loss (genetic, conductive, noise-induced, age-related, traumatic brain injury-related) and environmental noise. We are particularly interested in plastic changes in the brain that compensate for some aspects of altered auditory input, and how those changes relate to central auditory processing deficits, tinnitus, and hyperacusis. Understanding these changes will help refine therapeutic strategies and identify new targets for treatment. We collaborate with other labs in the Depts. of Otolaryngology, Neuroscience, Neuropathology, the Wilmer Eye Institute, and the Applied Physics Laboratory at Johns Hopkins, in addition to labs outside the university to increase the impact and clinical relevance of our research. view more

    Research Areas: hearing disorders, compound action potentials, auditory brainstem response, otoacoustic emissions, operation conditions, audiology, acoustic startle modification, hearing, neurology
  • Ayse Gurses Lab

    Work in the Ayse Gurses Lab examines several topics related to human factors, including methods... for improving patient safety in the cardiac operating room, care coordination, transitions of care and compliance of providers with evidence-based guidelines. Our team also has an interest in research that explores the working conditions of nurses. We collaborate on studies related to the development of geriatrics health service delivery at all levels of the health system. view more

    Research Areas: patient safety, human factors, informatics, care coordination, evidence-based medicine, gerontology
  • Bakker Memory Lab

    Lab Website

    Research in the Bakker Memory Laboratory is focused on understanding the mechanisms and brain n...etworks underlying human cognition with a specific focus on the mechanisms underlying learning and memory and the changes in memory that occur with aging and disease. We use a variety of techniques including neuropsychological assessments, experimental behavioral assessments and particularly advanced neuroimaging methods to study these questions in young and older adults and patients with mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease and epilepsy.

    Through our collaborations with investigators in both basic science and clinical departments, including the departments of Psychiatry and Behavioral Sciences, Psychological and Brain Sciences, Neurology and Public Health, our research also focuses on brain systems involved in spatial navigation and decision-making as well as cognitive impairment in neuropsychiatric conditions such as schizophrenia, eating disorders, obsessive-compulsive disorders, depression and anxiety.
    view more

    Research Areas: epilepsy, depression, Parkinson's disease, Alzheimer's disease
  • Balagopal Lab - Viral Hepatitis and Translational Virology

    Principal Investigator:
    Ashwin Balagopal, M.D.
    Medicine

    The Balagopal Lab has adapted high-resolution tools to study viruses in situ. Specifically, we ...were the first to quantify hepatitis C virus (HCV) infection in single hepatocytes by developing single-cell laser capture microdissection (scLCM) and integrating this tool with highly sensitive quantitative real-time PCR. We reported that HCV infects a minority of hepatocytes that are found in geospatial clusters. More recently, we (PIs Balagopal and Thio) integrated scLCM with droplet digital PCR (ddPCR) to reveal the first observations of hepatitis B virus (HBV) infection at single cell resolution in the liver. We found that HBV infects nearly all hepatocytes prior to antiviral therapy. However, during antiviral therapy, HBV infection is diminished while viral transcription is markedly attenuated.

    Our lab has also focused on HIV-1 infection and immune activation for over a decade. Most recently, we have studied type 1 interferon responses to HIV-1 using RNA sequencing (RNAseq). Using this technology, we identified novel interferon-stimulated genes (ISGs) that are associated with HIV-1 restriction in vivo.
    view more

    Research Areas: HIV-1, hepatitis B, hepatitis C
  • Beer Lab

    Lab Website

    The goal of research in the Beer Lab is to understand how gene regulatory information is encode...d in genomic DNA sequence. Our work uses functional genomics DNase-seq, ChIP-seq, RNA-seq, and chromatin state data to computationally identify combinations of transcription factor binding sites that operate to define the activity of cell-type specific enhancers. We are currently focused on improving SVM methodology by including more general sequence features and constraints predicting the impact of SNPs on enhancer activity (delta-SVM) and GWAS association for specific diseases, experimentally assessing the predicted impact of regulatory element mutation in mammalian cells, systematically determining regulatory element logic from ENCODE human and mouse data, and using this sequence based regulatory code to assess common modes of regulatory element evolution and variation. view more

    Research Areas: computational biology, biomedical engineering, DNA, genomics, RNA
  • Benjamin Bodnar Lab

    Principal Investigator:
    Benjamin Bodnar, M.D.
    Medicine

    Research in the Benjamin Bodnar Lab focuses on global health, particularly the application of q...uality-improvement techniques in resource-limited and developing health care environments. Lab work utilizes insights gained through Dr. Bodnar's past work with projects including Partners in Health, The Millennium Villages Project and the Mulago University-Yale University Collaboration in Uganda. view more

    Research Areas: global health, quality improvement
  • Berger Lab

    Lab Website
    Principal Investigator:
    James Berger, Ph.D.
    Biophysics and Biophysical Chemistry

    The Berger Lab's research is focused on understanding how multi-subunit assemblies use ATP for ...overcoming topological challenges within the chromosome and controlling the flow of genetic information. A long-term goal is to develop mechanistic models that explain in atomic level detail how macromolecular machines transduce chemical energy into force and motion, and to determine how cells exploit and control these complexes and their activities for initiating DNA replication, shaping chromosome superstructure and executing myriad other essential nucleic-acid transactions.

    Our principal approaches include a blend of structural (X-ray crystallography, single-particle EM, SAXS) and solution biochemical methods to define the architecture, function, evolution and regulation of biological complexes. We also have extensive interests in mechanistic enzymology and the study of small-molecule inhibitors of therapeutic potential, the development of chemical approaches to trapping weak protein/protein and protein/nucleic acid interactions, and in using microfluidics and single-molecule approaches for biochemical investigations of protein dynamics.
    view more

    Research Areas: biochemistry, proteomics, ATP, DNA, genomics
  • Bert Vogelstein Laboratory

    Lab Website
    Principal Investigator:
    Bert Vogelstein, M.D.
    Oncology

    The Bert Vogelstein Laboratory seeks to develop new approaches to the prevention or treatment o...f cancers through a better understanding of the genes and pathways underlying their pathogenesis.

    Our major focus is on cancers of the colon and rectum. We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. This expansion gives rise to a small benign colon tumor (called a polyp or adenoma). This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. As the mutations accumulate, the tumors become progressively more dangerous.

    Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management.
    view more

    Research Areas: rectal cancer, colon cancer, genomics, pathogenesis
  • Best Laboratory

    The Best Laboratory focus on therapeutic vaccine development for HPV-related diseases by develo...ping a murine model of papilloma analogous to Recurrent Respiratory Papillomatosis (RRP) for testing of DNA vaccine technology. We also work to understand the immunosuppressive tumor microenvironment that facilitates RRP development, and translate this work into novel therapies and clinical practice. view more

    Research Areas: Recurrent Respiratory Papillomatosis, HPV-related diseases, vaccines, Laryngeal papillomas, otolaryngology, papillomas, DNA vaccine technologies
  • Bimal Ashar Lab

    Principal Investigator:
    Bimal Ashar, M.D., M.B.A.
    Medicine

    Research in the Bimal Ashar Lab focuses on preventive medicine, medical education and dietary s...upplements. Recent research explored medical residents' knowledge of dietary supplements and examined the reported validity and reliability of methods for evaluating continuing medical education. view more

    Research Areas: primary care, medical education, preventive medicine, dietary supplements
  • Biophotonics Imaging Technologies (BIT) Laboratory

    Lab Website
    Principal Investigator:
    Xingde Li, Ph.D.
    Biomedical Engineering

    Research in the Biophotonics Imaging Technologies (BIT) Laboratory focuses on developing optica...l imaging and nano-biophotonics technology to reduce the random sampling errors in clinical diagnosis, improve early disease detection and guidance of biopsy and interventions, and improve targeted therapy and monitoring treatment outcomes. The imaging technologies feature nondestructiveness, unique functional and molecular specificity, and multi-scale resolution (from organ, to architectural morphology, cellular, subcellular and molecular level). The nano-biophotonics technologies emphasize heavily on biocompatibility, multi-function integration and fast track clinical translation. These imaging and nano-biophotonics technologies can also be potentially powerful tools for basic research such as for drug screening, nondestructive assessment of engineered biomaterials in vitro and in vivo, and for studying brain functions on awake animals under normal or controlled social conditions. view more

    Research Areas: drug screening, imaging, brain, nano-biophotonics
  • Borahay Lab: Gynecologic and Fibroids Research

    Lab Website

    Dr. Borahay's lab focuses on understanding pathobiology, developing novel treatments, and carry...ing out high quality clinical trials for common gynecologic problems with a special focus on uterine fibroids. Our lab also investigates the causes and novel treatments for menstrual disorders such as heavy and irregular periods. In addition, Dr. Borahay’s team explores innovative approaches to minimally invasive gynecologic surgery, focusing on outpatient procedures with less pain and faster recovery times. view more

    Research Areas: uterine fibroids, outpatient surgery, endometriosis, stem cells, tumor biology, laparoscopic surgery, novel therapeutics, signaling pathways, Uterine biology, menstruation, robotic surgery, minimally invasive surgery, heavy periods, tissue engineering, menorrhagia, uterine model
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