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  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our... recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders. view more

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis
  • Allan Gottschalk Lab

    Research in the Allan Gottschalk Lab focuses on the mechanisms behind neuropathic pain, chronic... pain related to nerve injury. We are investigating biophysical models of the impact of general anesthesia on the central nervous system; informational aspects of sensory perception and the representation of sensory input; nonlinear dynamics of respiratory pattern generation; and acute perioperative pain. view more

    Research Areas: sensory perception, nerve injury, central nervous system, neuropathy, neuropathic pain, anesthesia, pain
  • ALS Center

    Lab Website
    Principal Investigator:
    Nicholas Maragakis, M.D.
    Neurology

    The ALS Center for Cell Therapy and Regeneration Research at Johns Hopkins is committed to iden...tifying the causes of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), and discovering new and effective treatment options. At the ALS Center, Johns Hopkins researchers work with other investigators, including those at the Robert Packard Center for ALS Research at Johns Hopkins and clinicians within the Johns Hopkins ALS Clinic to aggressively take groundbreaking scientific discoveries and turn them into clinical applications that will improve the quality of life of those diagnosed with ALS. view more

    Research Areas: ALS
  • Alyssa Parian Lab

    Principal Investigator:
    Alyssa Parian, M.D.
    Medicine

    The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory ...bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations. view more

    Research Areas: inflammatory bowel disease, cancer, displaysia
  • Alzheimer's Disease Research Center

    Lab Website
    Principal Investigator:
    Marilyn Albert, Ph.D.
    Neurology

    The goal of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) is to accelerate the d...iscovery of new treatments that are directed at the basic mechanisms of disease, and to hasten the time when effective treatments for AD and related disorders become a reality. We have a strong commitment to basic research regarding the underlying mechanisms of Alzheimer's Disease and related disorders, and how this may translate into effective treatment. We perform clinical research seeking to identify medications to delay or treat the symptoms of dementia. We also provided many educational programs for family members and professionals. view more

    Research Areas: dementia, Alzheimer's disease
  • Ami Shah Lab

    Lab Website
    Principal Investigator:
    Ami Shah, M.D.
    Medicine

    Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. We examine the rela...tionship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud’s phenomenon, and drugs that improve aspects of scleroderma. view more

    Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases
  • Amit Pahwa Lab

    Principal Investigator:
    Amit Pahwa, M.D.
    Medicine

    The Amit Pahwa Lab conducts research on a variety of topics within internal medicine. Our most ...recent studies have explored misanalysis of urinalysis results, urinary fractional excretion indices in the evaluation of acute kidney injury and nocturnal enuresis as a risk factor for falls in older women. We also investigate cancer diagnostics and treatments. In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium. view more

    Research Areas: acute kidney injury, cancer, internal medicine, urology
  • Amita Gupta Lab

    Principal Investigator:
    Amita Gupta, M.D., M.H.S.
    Medicine

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and othe...r co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health. view more

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis
  • Amy Kim Lab

    Principal Investigator:
    Amy K. Kim, M.D.
    Medicine

    The Amy Kim Lab performs basic, translational, and clinical research on liver lesions and hepat...ocellular carcinoma. view more

    Research Areas: Liver lesions, hepatocellular carcinoma
  • Amy Knight Lab

    Principal Investigator:
    Amy Knight, M.D.
    Medicine

    Research in the Amy Knight Lab focuses on methods by which information technology can improve t...he quality of health care. We investigate the role computer systems can play in expanding patient-doctor communication, streamlining healthcare tasks for both medical students and practitioners, and establishing a higher standard of care. Our studies have explored the effectiveness of semi-automating daily progress notes for improved documentation, peer assessment of professional performance among hospitalists, ways to enable patient-centered care using information technology and other topics. view more

    Research Areas: outcomes, patient-provider relationships, internal medicine, information technology
  • Ana-Marie Orbai Lab

    Lab Website
    Principal Investigator:
    Ana-Maria Orbai, M.D., M.H.S.
    Medicine

    The Ana-Marie Orbai Lab focuses on inflammatory arthritis. Current clinical research projects i...n the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Previous research in the lab focused on systemic lupus erythemaous (SLE). view more

    Research Areas: autoimmune rheumatic diseases, arthritis, rheumatoid arthritis
  • Andrea Cox Lab

    Principal Investigator:
    Andrea Cox, M.D., Ph.D.
    Medicine

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a... focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design. view more

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells
  • Andrew Feinberg Laboratory

    Lab Website
    Principal Investigator:
    Andrew Feinberg, M.D., M.P.H.
    Medicine

    The Feinberg Laboratory studies the epigenetic basis of normal development and disease, includi...ng cancer, aging and neuropsychiatric illness. Early work from our group involved the discovery of altered DNA methylation in cancer as well as common epigenetic (methylation and imprinting) variants in the population that may be responsible for a significant population-attributable risk of cancer.

    Over the last few years, we have pioneered the field of epigenomics (i.e., epigenetics at a genome-scale level), founding the first NIH-supported NIH epigenome center in the country and developing many novel tools for molecular and statistical analysis. Current research examines the mechanisms of epigenetic modification, the epigenetic basis of cancer, the invention of new molecular, statistical, and epidemiological tools for genome-scale epigenetics and the epigenetic basis of neuropsychiatric disease, including schizophrenia and autism.
    view more

    Research Areas: autism, cancer, epigenetics, schizophrenia, human development, aging, DNA, genomics, neuropsychiatric disease
  • Andrew Laboratory: Center for Cell Dynamics

    Lab Website
    Principal Investigator:
    Deborah Andrew, Ph.D., M.S.
    Cell Biology

    Researchers in the Center for Cell Dynamics study spatially and temporally regulated molecular ...events in living cells, tissues and organisms. The team develops and applies innovative biosensors and imaging techniques to monitor dozens of critical signaling pathways in real time. The new tools help them investigate the fundamental cellular behaviors that underlie embryonic development, wound healing, cancer progression, and functions of the immune and nervous systems. view more

    Research Areas: immunology, cancer, epithelial tube, nervous system, molecular biology
  • Andrew Lane Lab

    The Lane laboratory is focused on understanding molecular mechanisms underlying chronic rhinosi...nusitis, particularly the pathogenesis of nasal polyps, as well as inflammation on the olfactory epithelium. Diverse techniques in molecular biology, immunology, and physiology are utilized to study epithelial cell innate immunity, olfactory loss, and response to viral infection. Ongoing work explores how epithelial cells of the sinuses and olfactory mucosa participate in the immune response and contribute to chronic inflammation. The lab creates and employs transgenic mouse models of chronic nasal/sinus inflammation to support research in this area. Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and COVID-19. view more

    Research Areas: nasal polyps, immunology, COVID-19, olfaction, cell culture, transgenic mice, chronic rhinosinusitis, innate immunity, neuroscience, molecular biology
  • Andrew McCallion Laboratory

    Principal Investigator:
    Andy McCallion, Ph.D.
    Molecular and Comparative Pathobiology

    The McCallion Laboratory studies the roles played by cis-regulatory elements (REs) in controlli...ng the timing, location and levels of gene activation (transcription). Their immediate goal is to identify transcription factor binding sites (TFBS) combinations that can predict REs with cell-specific biological control--a first step in developing true regulatory lexicons.

    As a functional genetic laboratory, we develop and implement assays to rapidly determine the biological relevance of sequence elements within the human genome and the pathological relevance of variation therein. In recent years, we have developed a highly efficient reporter transgene system in zebrafish that can accurately evaluate the regulatory control of mammalian sequences, enabling characterization of reporter expression during development at a fraction of the cost of similar analyses in mice. We employ a range of strategies in model systems (zebrafish and mice), as well as analyses in the human population, to illuminate the genetic basis of disease processes. Our long-term objective is to use these approaches in contributing to improved diagnostic, prognostic and therapeutic strategies in patient care.
    view more

    Research Areas: cell biology, genomics, gene regulation, nervous system
  • Aniket Sidhaye Lab

    Lab Website
    Principal Investigator:
    Aniket Sidhaye, M.D.
    Medicine

    Dr. Sidhaye is interested in improving the care of persons with cystic fibrosis, type 1 diabete...s mellitus and hospitalized person with diabetes. research topics include bone health of persons with CF undergoing lung transplant, CF-related diabetes mellitus, Care of persons with type 1 diabetes mellitus transitioning from pediatrics to adult specialty clinics, Management of hospitalized persons with diabetes. view more

    Research Areas: biochemistry, obesity, hormones, diabetes, transitional care, endocrinology, thyroid
  • Anne Marie Lennon Lab

    The Lennon Lab does clinical and translational research on endoscopic ultrasound, esophageal ca...ncer, gastric cancer, gastroenterology, pancreatic cancer, pancreatic cysts, therapeutic endoscopy, Von Hippel-Lindau (VHL)

    view more

    Research Areas: Von Hippel-Lindau (VHL), gastroenterology, pancreatic cancer, Endoscopic Ultrasound, Esophageal Cancer, Pancreatic Cysts, Therapeutic Endoscopy, Gastric Cancer
  • Anne Rompalo Lab

    Principal Investigator:
    Anne Rompalo, M.D.
    Medicine

    Research in the Anne Rompalo Lab focuses on STD research and application. We recently examined ...the relationship between violence against women and HIV-related risk factors in women living in the United States. Past projects include a nine-year longitudinal observation study of HIV-infected women in Baltimore. view more

    Research Areas: women, HIV, sexually transmitted diseases, domestic violence
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