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  • Allen Lab

    The Allen Lab focuses on immunologic aspects of cancer development and progression, with a focus on head and neck squamous cell carcinoma, the most common form of head and neck cancer. Work also aims to translate key knowledge learned from our investigation into anti-tumor immunity to other diseases in otolaryngology, including inflammatory and infectious disorders.

    Research Areas: anti-tumor immunity, otolaryngology, cancer, head and neck cancer, Squamous cell carcinoma

  • ALS Center

    The ALS Center for Cell Therapy and Regeneration Research at Johns Hopkins is committed to identifying the causes of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), and discovering new and effective treatment options. At the ALS Center, Johns Hopkins researchers work with other investigators, including those at the Robert Packard Center for ALS Research at Johns Hopkins and clinicians within the Johns Hopkins ALS Clinic to aggressively take groundbreaking scientific discoveries and turn them into clinical applications that will improve the quality of life of those diagnosed with ALS.

    Research Areas: ALS

    Lab Website

    Principal Investigator

    Nicholas Maragakis, M.D.

    Department

    Neurology

  • Alyssa Parian Lab

    The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations.

    Research Areas: inflammatory bowel disease, cancer, displaysia

    Principal Investigator

    Alyssa Parian, M.D.

    Department

    Medicine

  • Alzheimer's Disease Research Center

    The goal of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) is to accelerate the discovery of new treatments that are directed at the basic mechanisms of disease, and to hasten the time when effective treatments for AD and related disorders become a reality. We have a strong commitment to basic research regarding the underlying mechanisms of Alzheimer's Disease and related disorders, and how this may translate into effective treatment. We perform clinical research seeking to identify medications to delay or treat the symptoms of dementia. We also provided many educational programs for family members and professionals.

    Research Areas: dementia, Alzheimer's disease

    Lab Website

    Principal Investigator

    Marilyn Albert, Ph.D.

    Department

    Neurology

  • Ami Shah Lab

    Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. We examine the relationship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud’s phenomenon, and drugs that improve aspects of scleroderma.

    Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases

    Lab Website

    Principal Investigator

    Ami Shah, M.D.

    Department

    Medicine

  • Amit Pahwa Lab

    The Amit Pahwa Lab conducts research on a variety of topics within internal medicine. Our most recent studies have explored misanalysis of urinalysis results, urinary fractional excretion indices in the evaluation of acute kidney injury and nocturnal enuresis as a risk factor for falls in older women. We also investigate cancer diagnostics and treatments. In this area, our recent research has included studying cutaneous shave biopsies for diagnosing primary colonic adenocarcinoma as well as growth inhibition and apoptosis in human brain tumor cell lines using selenium.

    Research Areas: acute kidney injury, cancer, internal medicine, urology

    Principal Investigator

    Amit Pahwa, M.D.

    Department

    Medicine

  • Amita Gupta Lab

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and other co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health.

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis

    Principal Investigator

    Amita Gupta, M.D.

    Department

    Medicine

  • Amy Knight Lab

    Research in the Amy Knight Lab focuses on methods by which information technology can improve the quality of health care. We investigate the role computer systems can play in expanding patient-doctor communication, streamlining healthcare tasks for both medical students and practitioners, and establishing a higher standard of care. Our studies have explored the effectiveness of semi-automating daily progress notes for improved documentation, peer assessment of professional performance among hospitalists, ways to enable patient-centered care using information technology and other topics.

    Research Areas: outcomes, patient-provider relationships, internal medicine, information technology

    Principal Investigator

    Amy Knight, M.D.

    Department

    Medicine

  • Ana-Marie Orbai Lab

    The Ana-Marie Orbai Lab focuses on inflammatory arthritis. Current clinical research projects in the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Previous research in the lab focused on systemic lupus erythemaous (SLE).

    Research Areas: autoimmune rheumatic diseases, arthritis, rheumatoid arthritis

    Lab Website

    Principal Investigator

    Ana-Maria Orbai, M.D., M.H.S.

    Department

    Medicine

  • Anderson Lab

    Research in the Anderson laboratory focuses on cellular signaling and ionic mechanisms that cause heart failure, arrhythmias and sudden cardiac death, major public health problems worldwide. Primary focus is on the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII). The laboratory identified CaMKII as an important pro-arrhythmic and pro-cardiomyopathic signal, and its studies have provided proof of concept evidence motivating active efforts in biotech and the pharmaceutical industry to develop therapeutic CaMKII inhibitory drugs to treat heart failure and arrhythmias.

    Under physiological conditions, CaMKII is important for excitation-contraction coupling and fight or flight increases in heart rate. However, myocardial CaMKII is excessively activated during disease conditions where it contributes to loss of intracellular Ca2+ homeostasis, membrane hyperexcitability, premature cell death, and hypertrophic and inflammatory transcription. These downstream targets a...ppear to contribute coordinately and decisively to heart failure and arrhythmias. Recently, researchers developed evidence that CaMKII also participates in asthma.

    Efforts at the laboratory, funded by grants from the National Institutes of Health, are highly collaborative and involve undergraduate assistants, graduate students, postdoctoral fellows and faculty. Key areas of focus are:
    • Ion channel biology and arrhythmias
    • Cardiac pacemaker physiology and disease
    • Molecular physiology of CaMKII
    • Myocardial and mitochondrial metabolism
    • CaMKII and reactive oxygen species in asthma

    Mark Anderson, MD, is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital.
    view more

    Research Areas: heart failure, arrhythmia, cardiovascular diseases, sudden cardiac death

    Lab Website

    Principal Investigator

    Mark Anderson, M.D., Ph.D.

    Department

    Medicine

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