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  • Albert Lau Lab

    The Lau Lab uses a combination of computational and experimental approaches to study the atomic and molecular details governing the function of protein complexes involved in intercellular communication. We study ionotropic glutamate receptors (iGluRs), which are ligand-gated ion channels that mediate the majority of excitatory synaptic transmission in the central nervous system. iGluRs are important in synaptic plasticity, which underlies learning and memory. Receptor dysfunction has been implicated in a number of neurological disorders.

    Research Areas: central nervous system, synaptic plasticity, computational biology, intracellular communication, ionotropic glutamate receptors, neurological disorders

  • Alex Kolodkin Laboratory

    Research in the Alex Kolodkin Laboratory is focused on understanding how neuronal connectivity is established during development. Our work investigates the function of extrinsic guidance cues and their receptors on axonal guidance, dendritic morphology and synapse formation and function. We have investigated how neural circuits are formed and maintained through the action of guidance cues that include semaphorin proteins, their classical plexin and neuropilin receptors, and also novel receptors. We employ a cross-phylogenetic approach, using both invertebrate and vertebrate model systems, to understand how guidance cues regulate neuronal pathfinding, morphology and synaptogenesis. We also seek to understand how these signals are transduced to cytosolic effectors. Though broad in scope, our interrogation of the roles played by semaphorin guidance cues provides insight into the regulation of neural circuit assembly and function. Our current work includes a relatively new interest in ...understanding the origins of laminar organization in the central nervous system. view more

    Research Areas: central nervous system, neural circuits, neurodevelopment, neuronal connectivity, laminar organization

    Lab Website

    Principal Investigator

    Alex Kolodkin, Ph.D.

    Department

    Neuroscience

  • Alfredo Kirkwood Laboratory

    Research in the Alfredo Kirkwood Laboratory is directed toward elucidating the basic mechanisms by which visual experience can modify cortical connections in the visual cortex and how those mechanisms are regulated.

    In visual cortical slices, we investigate two forms of activity-dependent synaptic plasticity: long-term potentiation (LTP) and long-term depression (LTD). These two forms of synaptic plasticity are currently the most comprehensive models of the elementary mechanisms underlying naturally occurring plasticity. We are currently focused on how synaptic inhibition and the action of neuromodulators regulate the induction of LTP and LTD during development. We hope to gain a better understanding of how naturally occurring plasticity is regulated.

    Research Areas: synaptic plasticity, depression, vision, visual cortex, long-term potentiation

    Lab Website

    Principal Investigator

    Alfredo Kirkwood, M.S., Ph.D.

    Department

    Neuroscience

  • Aliaksei Pustavoitau Lab

    The Aliaksei Pustavoitau Lab conducts research on models and mechanisms of impaired consciousness in patients who have suffered acute brain injury. Examples of our work include a study on the mechanisms of neurologic failure in critical illness and another on the use of intensivist-driven ultrasound at the PICU bedside. We also have a longstanding interest in patient safety and quality of care in the ICU setting.

    Research Areas: patient safety, brain, consciousness, ICU, brain injury

  • Alicia Arbaje Lab

    Research in the Alicia Arbaje Lab aims to help older adults maintain dignity and quality of life as they age. We are particularly interested in creating health care systems to improve safety and outcomes for older adults.

    Research Areas: safety, gerontology, health care systems

    Principal Investigator

    Alicia Arbaje, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Alison E. Turnbull Lab

    Research in the Alison E. Turnbull Lab focuses on patient-clinician interactions. We study decision-making processes for ICU patients and their families and focus on the long-term outcomes of ICU survivors. Additional research examines ways to improve end-of-life care for patients.

    Research Areas: epidemiology, palliative care, medical decision making, ICU

  • Alison Miles Lab

    Research in the Alison Miles Lab focuses on moral distress among pediatric intensive care unit (PICU) clinicians. We have interviewed practitioners involved in the long-term care of patients in the PICU from two months to two years. By identifying the challenges of these cases and what was learned, we hope to develop more effective stress-management strategies for providers. Providers who have less stress are better equipped to care for patients, including those living with chronic diseases. Our team hopes to ultimately improve the field of pediatric palliative care for patients, families and care providers.

    Research Areas: stress, intensive care

  • Alison Moliterno Lab

    The Alison Moliterno Lab studies the molecular pathogenesis of myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocytosis and idiopathic myelofibrosis. Our research is focused on the genetic and epigenetic lesions associated with MPDs, with the goal of improving diagnosis and treatment for these disorders.

    Research Areas: blood disorders, idiopathic myelofibrosis, essential thrombocytosis, epigenetics, genomics, polycythemia vera, myeloproliferative disorders

    Principal Investigator

    Alison Moliterno, M.D.

    Department

    Medicine

  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders.

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis

    Principal Investigator

    Allan Gelber, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Allan Gottschalk Lab

    Research in the Allan Gottschalk Lab focuses on the mechanisms behind neuropathic pain, chronic pain related to nerve injury. We are investigating biophysical models of the impact of general anesthesia on the central nervous system; informational aspects of sensory perception and the representation of sensory input; nonlinear dynamics of respiratory pattern generation; and acute perioperative pain.

    Research Areas: sensory perception, nerve injury, central nervous system, neuropathy, neuropathic pain, anesthesia, pain

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