Se-Jin Lee Lab

  • The primary interest of the Se-Jin Lee Lab is to understand the role of signaling molecules in regulating embryonic development and adult tissue homeostasis. Their research focuses on a family of secreted proteins that are structurally related to transforming growth factor-B (TGF-B). members of this growth factor family help regulate the development and function of different tissues. We have identified a large number of novel mammalian TGF-B family members that they have designated growth/differentiation factors (GDFs) and are using various approaches to understand the biological function of these molecules, specially the roles of these molecules in regulating tissue growth. Current research focuses on understanding how a molecule called myostatin affects skeletal muscle growth. Their long-term goal is to exploit the biological properties of myostatin to develop therapeutic strategies for treating patients with muscle degenerative and wasting conditions.

    Research Areas: myostatin, muscles, tissue growth, embryo, molecular biology