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Toward a Treatment for Barth Syndrome
Mitochondria are the powerhouses of the cell, producing the energy we need to live. So it’s no surprise that problems with mitochondria have severe effects on the body. One of these is Barth syndrome, a failure of the immune, skeletal and cardiac systems. Hilary Vernon researches mitochondria to discover possible treatment options for Barth syndrome.
Treating Diseases by Understanding Cell Identity
Patrick Cahan is making a tool that measures how closely cells grown in a lab mimic those in our bodies. This could help pave the way to replacing damaged tissue and more effectively studying diseases in the lab. Learn More
Keeping Memories Safe
Neurons store our memories and control all aspects of our bodily functions; they are what make us human. Ted Dawson’s research focuses on the culprits that kill neurons. His hope is to find ways to prevent the loss of neurons in Parkinson’s disease, stroke and other brain disorders. Learn More
Tapping into the Heart’s Strategy
Jennifer Lawton studies a channel in heart cells that protects the organ when energy is low. By understanding this protection mechanism, her team hopes it can find medications to reduce harm to the heart following heart surgery, heart attack or times of stress. Learn More
Treating Progeria in Children
Susan Michaelis and her team are studying a rare premature aging disease called progeria, which provides a unique window into the normal aging process. Learn More
How Odor Sensitive Cells Regenerate
Odor-sensitive cells can warn of us of dangers and let us know when something is pleasant to eat. When exposed to the outside world, these cells can die but are quickly replaced. Randall Reed is trying to understand how regeneration happens in hopes to prevent people from losing their sense of smell.
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Regenerating Damaged Tissues
What supports regeneration and how can we harness its healing power? Erika Matunis and her team are looking to identify conditions that allows stem cells to thrive. That knowledge could lead to innovative therapies to regenerate many kinds of damaged tissues. Learn More
Taking Away Cancer Cells’ Advantage
Mario Amzel' s team studies the proteins that give cancer cells an advantage over their healthy neighbors. This work could lead to new therapies to block the proteins' action. Learn More
Fighting Bacterial Resistance to Antibiotics
The growth of antibiotic-resistant bacteria has become a serious issue. Erin Goley’s laboratory is discovering the mechanisms that bacteria use to grow, divide and become resistant, in hopes of developing better antibiotic treatments.
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Precision Immunotherapy
Developed from 30 years of basic research at Johns Hopkins and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, an immunotherapy drug has now been FDA approved for cancer based on disease genetics rather than type. Bert Vogelstein and Dung Le describe this research milestone.Sign Up for Fundamentals
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