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Fundamentals

Zebrafish Help Unlock Clues to Human Disease

The Center for Functional Investigation in Zebrafish — or the FINZ center — is a research core facility of the McKusick-Nathans Institute of Genetic Medicine. Thirty different cores from departments across The Johns Hopkins University offer more than 500 different research-related services. The centers allow investigators to share valuable resources and expertise, saving both time and dollars.

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Tapping into the Heart’s Strategy

Jennifer Lawton studies a channel in heart cells that protects the organ when energy is low. By understanding this protection mechanism, her team hopes it can find medications to reduce harm to the heart following heart surgery, heart attack or times of stress.  

Natalia Trayanova

Natalia Trayanova on Virtual Hearts that Save Lives

Natalia Trayanova is a professor of biomedical engineering and medicine. Her lab creates predictive computer simulations to generate personalized virtual hearts to assess patient risk of sudden cardiac death and to guide personalized anti-arrhythmia interventions 

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Brain

Decoding the Brain’s Learning Machine

 Researchers have uncovered significant new details about how the cerebellum makes predictions and learns from its mistakes, helping us execute complex motor actions such as accurately shooting a basketball into a net. Learn more.
Fish eye

Image of the Month

Images have the power to stir the imagination and convey the beauty and wonder of science. Follow us on Instagram at JHM.Fundamentals. Each week, we feature science images contributed by Johns Hopkins researchers. Johns Hopkins Faculty and staff: Submit your research-related images to Fundamentals@jhmi.edu. Follow us.
Cilia

Scientists Develop Method to Tweak Tiny ‘Antenna’ on Cells

Researchers have found a fast way to manipulate a cell’s cilia. This may advance scientists’ efforts to  understand not only how the nanosized antennae work, but also how to repair them.  Learn more.
Microphone in the audience

When There’s an Audience, People’s Performance Improves

Researchers found that when people know they are being observed, parts of the brain associated with social awareness and reward invigorate a section of the brain that controls motor skills, improving their performance at skilled tasks.  Read more.
cells

Heart Failure: The Alzheimer’s Disease of The Heart?

Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer’s and Parkinson’s, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure.  Read more.