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Fundamentals

A Trajectory of Change in Mentorship

Three postdocs developed a mentoring program that has changed how underrepresented minority students at Johns Hopkins find support among their communities.

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Toward a Treatment for Barth Syndrome

Mitochondria are the powerhouses of the cell, producing the energy we need to live. So it’s no surprise that problems with mitochondria have severe effects on the body. One of these is Barth syndrome, a failure of the immune, skeletal and cardiac systems. Hilary Vernon researches mitochondria to discover possible treatment options for Barth syndrome. 

Vikram Chib

Vikram Chib on Motivation in the Brain

Vikram Chib is an assistant professor of biomedical engineering at Johns Hopkins Medicine. He studies the neuroscience behind what motivates us and how we make decisions. His lab recently made a discovery that being watched while you do a task can actually push you to do better.

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Highlights

Tubes

Image of the Month

Blood, sweat  and tears, all travel through tubes. But it took a lot of hard work to figure out how these structures form. By partnering with civil engineers, Andrew Ewald was able to use images like this one to create a model of the forces in action as cells tunnel a pipeline through tissue. Follow us.
Cancer cell

Scientists Discover a Dynamic Cellular Defense Against Breast Cancer Invasion

Researchers have demonstrated in mouse tissue grown in the lab that the cell layer surrounding breast milk ducts reaches out to grab stray cancer cells to keep them from spreading through the body. Learn more.
pH

pH Imbalance in Brain Cells May Contribute to Alzheimer’s Disease

Researchers have found evidence in lab-grown mouse brain cells that one root of Alzheimer’s disease may be a simple imbalance in pH chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells. Read more.
researcher pipetting

Turning Off Protein Could Boost Immunotherapy Effectiveness on Cancer Tumors

Researchers discovered that inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness of immunotherapy treatments. Read more.
Heart

Drug in Clinical Trials for Parkinson’s Might Also Help Treat Heart Failure

A member of a class of compounds known as phosphodiesterase (PDE) type I inhibitors shows promising effects on dog and rabbit hearts, as well as on isolated rabbit heart cells, most notably an increase in the strength of the heart muscle’s contractions, researchers say. Learn more.