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Discoveries for a Better Tomorrow

Cancer

Improving Quality of Life for Patients with Lung Cancer - Dr. Stephen Broderick

Dr. Stephen Broderick and his team investigate which treatments best protect quality of life—not just survival—for patients with lung cancer.

DNA Rearrangements That Cause Childhood Cancer - Dr. Stephen Desiderio

Dr. Stephen Desiderio and his team have discovered ways the immune system protects us from damage to our genes, gaining insight into the causes of leukemia.

Chemotherapy-Resistant Breast Cancer Stem Cells - Dr. Gregg Semenza

Dr. Gregg Semenza’s team has identified a way to overcome the resistance of cancer stem cells to chemotherapy, completely eradicating breast tumors in mice.

Repetitive DNA and Cancer - Dr. Kathleen Burns

Repetitive DNA constitute most of our genetic makeup, but much about their function is mysterious. Dr. Kathleen Burns studies repetitive DNA to detect and kill cancer cells.

Understanding the Immune System— Dr. Joel Pomerantz

Better understanding white blood cells and the body’s immune response may help researchers detect and fight cancer. Dr. Joel Pomerantz and his team at Johns Hopkins study the immune system to this end.

Giving Immune Response a Nano-Boost— Dr. Jonathan Schneck

Can a custom-built white blood cell avoid suppression by cancer and boost our immune system? Dr. Jonathon Schneck has developed artificial antigen-presenting cells and is working to put them to use in the clinic.

Innovative Strategies for Treating Brain Tumors—Dr. Henry Brem

Normal brain tissue must be protected while doctors destroy a brain tumor. Researchers at Johns Hopkins are creating new, targeted treatments for brain tumor patients.

A Missile for Cancer — Dr. Theodore DeWeese

Dr. DeWeese and his team are testing a way to target a protein found on the surface of cancer cells, but not non-cancer cells. Their goal is to destroy cancer while protecting normal tissue.

Taking Away Cancer Cells’ Advantage — Dr. Mario Amzel

Dr. Amzel and his team are learning more about the proteins that give cancer cells an advantage over their healthy neighbors. Their work could lead to new therapies to block the proteins’ action.

Stopping the Spread of Breast Cancer Cells - Andrew Ewald, Ph.D.

Dr. Ewald's lab has discovered what allows breast cancer cells to leave the main tumor and build new tumors in the lungs, bones and brains. Now, their goal is to identify patients whose breast cancer is likely to spread so they can find ways to save their lives.

Solar Radiation on Skin – Sewon Kang, M.D.

Dermatologist Sewon Kang and his team are working on how radiation from the sun can bring about very different effects on human skin.

Treating Prostate Cancer – Urologic Oncologist Kenneth Pienta

Urologic oncologist Kenneth Pienta and his team are working to identify what keeps disseminated tumor cells asleep or reactivates them so that they can better treat prostate cancer.

Reducing Cancer Deaths – Nickolas Papadopoulos, Ph.D.

Nickolas Papadopoulos, Ph.D., and his team at the Ludwig Center at Johns Hopkins are developing a superbly sensitive test for mitosis by interrogating each individual’s molecule sample in patients with early-stage cancer.

Detecting Prostate Cancer Early – Alan Partin, M.D., Ph.D.

Alan Partin, M.D., Ph.D., and his research group develop and test blood, urine and tissue cells to detect prostate cancer early.

Protecting Against UV Radiation – Anna Chien, M.D.

Dr. Anna Chien and her team have discovered that visible light can cause skin inflammation and skin discoloration.

Improving Radiation Treatments for Children – Dr. Stephanie Terezakis

Dr. Stephanie Terezakis and her research team are looking for ways to deliver radiation more precisely to tumors and minimize radiation to healthy tissues.

Rethinking the Spread of Metastatic Cancer | Malcolm Brock, M.D.

Malcolm Brock, M.D., is studying ways to make cancer cells unable to spread, and ways to make other organs less fertile for cancer to take root.

Donors for Bone Marrow Transplant | Javier Bolaños-Meade, M.D.

Javier Bolaños-Meade, M.D., is working to expand the availability of donors for bone marrow transplants.