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For new Position Emission Tomography (PET) and Single-photon Emission Computed Tomography (SPECT) imaging projects at the Johns Hopkins Small Animal Imaging Resource Program (SAIRP), it is strongly recommended that the investigator contact the SAIRP staff to review the purpose and overall design of the study. This is important especially for investigators with little or no prior experience with animal imaging studies. The key points to discuss prior to performing any study include the study hypothesis, which modalities are most appropriate to the task, which studies are feasible, how many studies will be required, the study design, how to fill out scheduling and study request forms, investigators’ responsibilities, image acquisition and data analysis. To assist investigators with their imaging projects, the SAIRP has implemented a shepherding system whereby an SAIRP member is assigned to oversee or “shepherd” each project.