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Conditions We Treat: Endometrial Cancers

Radiation therapy is used to treat the vast majority of patients diagnosed with endometrial cancer. Our radiation oncologists use advanced radiation techniques and provide individualized treatment for each patient.

Endometrial Cancer: Why Choose Johns Hopkins

MR simulatorFigure 1: MR simulator
  • Our radiation oncologists use radiation techniques that reduce the risk of damaging the bowel and bladder as well as other healthy tissues. For example, we use image-guided intensity-modulated radiation therapy (IMRT) to match the exact shape and location of the tumor. Also, Johns Hopkins pioneered the integration and use of a spacer to separate the rectum from the vagina during brachytherapy. This technique allows the physician to separate the normal tissue from the cancerous tissue during radiation treatment, which helps minimize side effects.
  • Johns Hopkins radiation oncologist Akila Viswanathan, M.D., M.P.H., led the team that developed an image-guided brachytherapy program in a magnetic resonance (MR) simulator to manage advanced and recurrent endometrial cancers.
  • Our radiation oncologists are using special mobile computed tomography (CT) imaging technology for standard cylinder brachytherapy and MR imaging for multichannel cylinder and interstitial brachytherapy. The imaging helps ensure that the cancerous area is treated accurately and the normal tissue is protected during the applicator placement and evaluation. This technology application is unique to Johns Hopkins in the treatment of endometrial cancer.
  • Our radiation oncologists are uniquely using ultrasound-guided hydrogel spacer placement during radiation for endometrial cancer.
  • Our researchers use the latest clinical trials to develop new and improved endometrial cancer treatments.
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Our Team of Head and Neck Cancer Specialists

Our radiation oncologists create and deliver personalized treatment plans that target head and neck cancers safely and effectively.

Photo of Dr. Fariba Asrari, M.D.

Asrari, Fariba, M.D.

Director, Johns Hopkins Breast Center - Green Spring Station
Expertise, Disease and Conditions: Basal Cell Carcinoma (BCC), Bladder Cancer, Breast Cancer, Cervical Cancer, Endometrial Cancer, Esophageal Cancer, Gynecologic Cancers, Lung Cancer, Lymphoma, Medical Oncology, Melanoma, Metastatic Bone Disease, Non-Small Cell Lung Cancer, Pancreatic Cancer, Prostate Cancer, Radiation Oncology, Rectal Cancer, Skin Cancer, Small Cell Lung Cancer, Squameous Cell Carcinoma, Testicular Cancer, Vulvar Cancer
Photo of Dr. Victoria Jane Croog, M.D.

Croog, Victoria Jane, M.D.

Department of Radiation Oncology, Sibley Memorial Hospital
Expertise, Disease and Conditions: Brain Cancer, Brain Metastases, Breast Cancer, CNS Autoimmune/Inflammatory Disorders, Gastrointestinal Cancers, Gynecologic Cancers, Primary central nervous system (CNS) lymphoma, Radiation Oncology, Stereotactic Body Radiation Therapy
Photo of Dr. Susan Fletcher Stinson, M.D.

Stinson, Susan Fletcher, M.D.

Medical Director, Suburban Hospital Cancer Program
Expertise, Disease and Conditions: Breast Cancer, Grave's Obitopathy, Gynecologic Cancers, Keloids, Radiation Oncology
Photo of Dr. Akila Ninette Viswanathan, M.D., M.P.H., M.Sc.

Viswanathan, Akila Ninette, M.D., M.P.H., M.Sc.

Professor of Radiation Oncology and Molecular Radiation Sciences
Professor of Gynecology and Obstetrics
Professor of Oncology
Interim Director, Johns Hopkins Radiation Oncology and Molecular Radiation Sciences
Director of National Capital Region, Johns Hopkins Radiation Oncology and Molecular Radiation Sciences
Director of Johns Hopkins Gynecological Radiation Oncology
Expertise, Disease and Conditions: Brachytherapy, Gynecologic Cancers, Gynecologic Oncology, Radiation Oncology, Uterine Cancer

Our Endometrial Cancer Treatments

Our radiation oncologists use the following radiation therapies to treat endometrial cancer:

  • interstitial brachytherapyFigure 2: Interstitial brachytherapy for recurrent endometrial cancer
    Internal radiation (brachytherapy): Johns Hopkins is the only provider in the greater Maryland, Washington, D.C., and Virginia area that can use MR image-guided brachytherapy to treat endometrial cancer. By uniquely converting the MR simulator environment to an MR procedural environment, we include MR-based imaging and tracking to enable the most precise placement possible during the internal portion of radiation therapy. MR-based brachytherapy helps improve patient outcomes and minimize side effects.
    Our brachytherapy technologies include the following:
    • Cylinder: This type of radiation is used to treat the vaginal cuff after a hysterectomy to prevent the most common type of recurrence, which occurs in the vaginal cuff.
    • Multichannel cylinder: This type of radiation is used to treat patients who have a small-size recurrence of uterine (same as endometrial) cancer and do not require interstitial therapy. MR guidance in the simulator is used to maximize the radiation treatment to the tumor and minimize exposure to the normal tissue.
    graph of spared tissueFigure 3: Sparing normal tissue during brachytherapy
    • Double tandem: This type of radiation is used to treat women with inoperable uterine cancer, using either CT or MR imaging.
    • Interstitial: This type of radiation is used for women with a large-size recurrence of uterine cancer.
  • External beam radiation: This type of radiation is used to treat pelvic lymph nodes in endometrial cancer patients with a high risk of nodal involvement. External radiation may also be used to treat involved lymph nodes that were detected during surgery. Image-guided IMRT allows the most targeted radiation treatment possible.
external beam therapyFigure 4: External beam therapy for inoperable uterine cancer

For patients that develop recurrent cancer after endometrial cancer surgery, radiation is administered using a combination of external and internal radiation.

For most recurrent cases, radiation oncologists tend to use interstitial brachytherapy. Stereotactic radiosurgery (a form of external radiation) may be given to certain patients with recurrent disease.

Our Research

Gloved hand injecting liquid sample into test tube
  • Our researchers are investigating the next generation of hydrogel spacers for separating normal tissue from cancerous tissue during brachytherapy.
  • Johns Hopkins researchers have a prospective protocol that allows them to acquire tissue biopsies from tumors to study the genetic aspects of gynecologic cancers. The results could impact future cancer treatment and care standards.

Our Locations

Johns Hopkins Hospital

Johns Hopkins offers several convenient locations throughout the Baltimore-Washington, D.C., region that provide radiation therapy for endometrial cancer.

  • The Johns Hopkins Hospital
  • Johns Hopkins Health Care & Surgery Center — Green Spring Station
  • Sibley Memorial Hospital
  • Johns Hopkins Health Care & Surgery Center – Bethesda 

Learn more about our locations.

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