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Ken Kang-Hsin Wang, PhD

E-mail: kwang27@jhmi.edu

Interests: Optical tomography for pre-clinical radiation research; Imaging guided radiation therapy; Proton therapy

Title: Assistant Professor

Schools\degrees: University of Rochester\PhD, Physics

Clinical interests: Stereotactic treatment; Image guided radiation therapy; Proton therapy; Methods of motion management in radiation therapy

Research summary: My research interest is to develop cutting-edge biomedical technologies that bridge the basic physics/engineering research and pre- and clinical cancer therapy application. The main focus of my group is to advance optical imaging for soft tissue target localization and response assessment in preclinical radiation research. My research work is supported by the mechanism of Academia Industry Partnership (AIP) from NIH and industrial grants. My colleague and I have successfully integrated the cone-beam CT (CBCT) and bioluminescence tomography (BLT) to guide focal irradiation with the small animal radiation research platform (SARRP). Our work has led to Xstrahl’s, our industrial partner, commercialize the optical utility for the SARRP. To further bring the SARRP targeting and functional imaging capability to the next level, we will incorporate quantitative BLT and fluorescence tomography (FT). We believe that the tri-modal imaging system (CBCT/BLT/FT) will greatly expand the capabilities for pre-clinical radiation research that has not been the focus of the molecular optical imaging industry at large.

In addition to the biomedical optics, my research background spans a broad range of topics that cover photodynamic therapy (PDT), beam data modeling and quality assurance for radiation therapy, prostate motion management techniques and condensed matter physics. Please refer to the publication list for detail. 

Journal citations

Z. Ye, K. K-H (K-X) Wang. Localize energy in random media: A new phase state. Chin. J. Phys. 2000; 38, L1003-1007.

K. K-H (K-X) Wang, Z. Ye. Acoustic pulse propagation and wave localization in bubbly water. Phys. Rev. E. 2001; 64, 056607-1-9, PMID: 11736116.

K. K-H (K-X) Wang, Z. Ye. Collective behavior in electrical dipolar systems. J. Phys.: Condens. Matter, 2001; 13, 8031-8038.   

C.H. Kuo, K. K-H Wang, Z. Ye. Fluctuation and localization of acoustic waves in bubbly water. Appl. Phys. Lett. 2003; 83, 4247-4249.

K. K-H Wang, Z. Ye. Simulation study of localization electromagnetic waves in a two-dimensional random dipolar system. Phys. Rev. E., 2003, 68, 066609-1-6, PMID: 14754338.

K. K-H Wang, Z. Ye. Diffusive and localization behavior of electromagnetic waves in a two-dimensional random dipolar system. Phys. Rev. E., 2003, 68, 046608-1-10, PMID: 14683066.

K. K-H Wang, S. Mitra, T.H. Foster. A comprehensive mathematical model of microscopic dose deposition in photodynamic therapy. Med. Phys., 2007, 34, 282-293, PMID: 17278514, [Erratum:  Med. Phys. 35. 4278-4280 (2008)], (Selected to be published in Virtual Journal of Biological Physics Research)

K. K-H Wang, J.D. Wilson, M.E. Kenney, S. Mitra, T.H. Foster. Irradiation-induced enhancement of Pc 4 fluorescence and changes in light scattering are potential dosimeters for Pc 4-PDT. Photochem. Photobiol., 2007, 83, 1056-1062, PMID: 17880500.

K. K-H Wang, S. Mitra, T.H. Foster. Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals. Med. Phys. 2008, 35, 3518-3526, PMID: 18777912, PMCID: PMC2562246, (Selected to be published in Virtual Journal of Biological Physics Research)

K. K-H Wang, W.J. Cottrell, S. Mitra, A.R. Oseroff, T.H. Foster. Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow changes during 5-aminolevulinic acid-mediated photodynamic therapy. Lasers. Surg. Med., 2009, 41, 686 - 696, PMID: 19802891, PMCID: PMC2805271.

T.M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H.-W. Wang, T. Durduran, T.C. Zhu, K. K.-H. Wang. Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin-PDT. Photochem. Photobiol. Sci. 2009, 8, 1683-1693, PMID: 20024165, PMCID: PMC2834171.

K. K-H Wang and T. C. Zhu. Reconstruction of in-vivo optical properties for human prostate using interstitial diffuse optical tomography. Opt. Exp. 2009, 17, 11665-11672, PMID: 19582081, PMCID: PMC3276880.

K. K-H Wang, J. C. Finlay, T. C. Zhu. Reconstruction of optical properties using a diffusion model for interstitial diffuse optical tomography. Proc. of SPIE 2009; 7164, 71640P-71640P-9.

K. K-H Wang, T. M. Busch, J. C. Finlay, T. C. Zhu. Optimization of physiological parameter for macroscopic modeling of reacted singlet oxygen concentration in an in vivo model. Proc. of SPIE 2009; 7164, 71640O-71640O-12.

T. C. Zhu, M. D. Altschuler, Y. Hu, K. K.-H. Wang, A. Dimofte, K. Cengel, S. M. Hahn. A heterogeneous optimization algorithm for the optimization of reacted singlet oxygen for interstitial PDT. Proc. of SPIE, 2010; 7751, 75510E-75510E-9.

K. K-H Wang, J. C. Finlay, T. M. Busch, S. M. Hahn, and T. C. Zhu. Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling. J. Biophotonics. 2010, 3, 304-318, PMID: 20222102, PMCID: PMC3071971.

K. K-H Wang, T. C. Zhu. Modeling scatter-to-primary dose ratio for megavoltage photons. Med. Phys. 2010; 37, 5270-5278, PMID: 21089761.

S. Both, K. K-H Wang, J. Plastaras, C. Deville, V. Bar Ad, Z. Tochner, N. Vapiwala. Real-time study of prostate intrafraction motion during external beam radiotherapy with daily endorectal balloon. Int. J. Radiat. Oncol. Biol. Phys. 2011; 81, 1302-1309, PMID: 21035952.

X. Liang, K. K-H Wang, T. C. Zhu. Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography. Proc. of SPIE 2012; 8210, 82100C-82100C-8.

S. Both, C. Deville, V. Bui, K. K-H Wang, N. Vapiwala Emerging evidence for the role of an endorectal balloon in prostate radiation therapy. Transl. Cancer Res. Phys. 2012; 1, 227-235.

K. K-H Wang+, N. Vapiwala, C. Deville J. Plastaras, R. Scheuermann, H. Lin, V. Bar Ad, Z. Tochner, and S. Both. A study to quantify the effectiveness of daily endorectal balloon (ERB) for prostate intrafraction motion management. Int. J. Radiat. Oncol. Biol. Phys. 2012; 83,1055-1063, PMID: 22115790. +: corresponding author

S Tang, C. Deville, J McDonough, Z Tochner, K. K-H Wang, N. Vapiwala, S. Both. Effect of intrafraction prostate motion on proton pencil beam scanning delivery: A quantitative assessment. Int. J. Radiat. Oncol. Biol. Phys. 2013; 87, 375-382, PMID: 23958148.

X. Liang, K. K-H Wang, T. C. Zhu. Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fiber. Phys. Med. Biol. 2013; 58, 10, 3461-3480, PMID: 23629149, PMCID: PMC3759155.

K. K-H Wang+, N. Vapiwala, Viet B, C. Deville, J. Plastaras, V. Bar Ad, Z. Tochner, and S. Both. The impact of stool and gas volume on intrafraction prostate motion in patients undergoing radiotherapy with daily endorectal balloon. Radiother. Oncol. 2014; 112, 89-94, +: corresponding author.

S Tang, C. Deville, Z Tochner, K. K-H Wang, J McDonough, N. Vapiwala, S. Both. Impact of intrafraction and residual interfraction effect on prostate proton pencil beam scanning. Int. J. Radiat. Oncol. Biol. Phys. 2014; 90, 1186-1194.

Y. Yang*, K. K-H Wang*, S. Eslami, I. Iordachita, M. Naser, M. S. Patterson, J. W. Wong. Systematic calibration of an integrated x-ray and optical tomography system for preclinical radiation research. Med. Phys. 2015, 42, 1710-1720, *These authors contribute equally.

Y. Yang*, M. Armour, K. K-H Wang, N. Gandhi, I. Iordachita, J. Siewerdsen, J. W. Wong. Evaluation of a cone beam computed tomography geometry for image guided small animal irradiation. Phys. Med. Biol. 2015 60, 5163-5177.

M. Li, X. He, S. Eslami, K. K-H. Wang, B. Zhang, J. Wong, I. Iordachita. A dual-use imaging system for preclinical small animal radiation research. Proc. 37th Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society (EMBS), Milano, Italy, 2015, 6904-6907.

C. Yang, D.-H. Lee, A. Mangraviti, L. Su, K. Zhang, Y. Zhang, B. Zhang, W. Li, B. Tyler, J. Wong, K. K.-H. Wang, E. Velarde, J. Zhou, and K. Ding. Quantitative correlational study of microbubble-enhanced ultrasound Imaging and magnetic resonance imaging of glioma and response to radiotherapy in a rat model. Med. Phys. 2015, 42, 4762-4772.

Y. Zhang, K. Ding, G. Cowan, E. Tryggestad, E. Armour, and K. K-H Wang+ “Alignment of multi-radiation isocenters for megavoltage photon beam.” J. Appl. Clin. Med. Phys., 2015, 16, 314-324, +: corresponding author.

B. Zhang*, K. K-H Wang*,+, J. Yu, S. Eslami, J. Reyes, R. Malek, P. Tran, I. Iordachita, M. S. Patterson and J. W. Wong, “Bioluminescence tomography-guided radiation therapy for preclinical research” Int. J. Radiat. Oncol. Biol. Phys., DOI: 10.1016/j.ijrobp.2015.11.039, *These authors contribute equally,+:corresponding author.
 

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