The Atsushi Kamiya Lab

Kamiya Lab Team 2018

Atsushi Kamiya, M.D., Ph.D. 

Research Overview

The goal of our research is to understand the molecular and circuit mechanisms underlying etiopathophysiologies of psychiatric disorders, such as schizophrenia and depression. In particular, we investigate how genetic risk factors and environmental factors, such as adolescent cannabis use and psychosocial stress, affect stress-related biological signaling mechanisms, including immune and inflammatory processes, leading to impairment of brain development and brain function that regulates cognitive and mood-related behaviors.

We hope our research ultimately identifies new therapeutic targets and biological markers for early intervention of these devastating conditions.

Selected Publications

Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, O., Okawa, M., Ross, C.A., Hatten, M.E., Nakajima, K., Sawa, A.: A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.  Nature Cell Biol., 7; 1167-1178 (2005).

Taniguchi, Y, Young-Pearse, T, Sawa, A, Kamiya, A.: In utero electroporation as a tool for genetic manipulation in vivo in order to study psychiatric disorders: from genes to circuits and behaviors.  Neuroscientist 18;169-79 (2012). 

Golzio, C., Willer, J., Talkowski, M.E., Oh, E.C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J.F., Kamiya, A., Beckmann, J.S., Katsanis, N.: KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature 7398; 363-367 (2012).

Ballinger, MD., Saito, A., Abazyan, B., Taniguchi, Y., Huang, CH., Ito, K., Zhu, X., Segal, H.,  Jaaro-Peled., Sawa, A., Mackie, K., Pletnikov, MV., Kamiya, A.: Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory. Neurobiology of Disease 82; 176-184 (2015).

Saito, A., Taniguchi, Y., Rannals, M., Merfeld, EB., Ballinger, MD., Koga, M., Ohtani, Y., Gurley, DA., Sedlak, TW., Cross, A., Moss, SJ., Brandon, NJ., Maher, BJ., Kamiya, A.: Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Molecular Psychiatry 10; 1449-1459 (2016).

Saito, A., Taniguchi, Y., Kim, SH., Selvakumar, B., Perez, G., Ballinger, MD., Zhu, X., Sabra, J., Jallow, M., Yan, P., Ito, K., Rajendran, S., Hirotsune, S., Wynshaw-Boris, Snyder, SH., Sawa, A., Kamiya, A.: Developmental alcohol exposure impairs activity-dependent S-Nitrosylation of NDEL1 for neuronal maturation.  Cerebral Cortex 27; 3918-3929 (2016).

Jouroukhin, Y., Zhu, X., Shevelkin, AV., Hasegawa, Y., Abazyan, B., Saito, A., Pevsner, J., Kamiya, A., Pletnikov, MV.: Adolescent Δ9-THC exposure and astrocyte-specific genetic vulnerability converge on NF-κB-COX-2 signaling to impair memory in adulthood. Biol Psychiatry (2018).

Zhu, X., Nedelcovych, M., Thomas, A.G., Hasegawa, Y., Moreno-Megui, A., Commer, W., Vohra, V., Saito, A., Perez, G., Wu, Y., Alt, J., Prchalova, E., Tenora, L., Majer, P., Rais, R., Rojas, C., Slusher, B.S., Kamiya, A.: JHU-083 Selectively Blocks Glutaminase Activity in Brain CD11b+ cells and Prevents Depression-associated Behaviors Induced by Chronic Social Defeat Stress. Neuropsychopharmacology (2018).