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Selected Research Publications

Silvio O. Conte Center for Schizophrenia Research at Johns Hopkins


Jaaro-Peled, H., Hayashi-Takagi, A., Seshadri, S., Kamiya, A., Brandon, N.J., and Sawa, A. (2009). Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci 32, 485-495 [Abstract]

Khanna, H., Davis, E.E., Murga-Zamalloa, C.A., Estrada-Cuzcano, A., Lopez, I., den Hollander, A.I., Zonneveld, M.N., Othman, M.I., Waseem, N., Chakarova, C.F., Maubaret, C., Diaz-Font, A., MacDonald, I., Muzny, D.M., Wheeler, D.A., Morgan, M., Lewis, L.R., Logan, C.V., Tan, P.L., Beer, M.A., Inglehearn, C.F., Lewis, R.A., Jacobson, S.G., Bergmann, C., Beales, P.L., Attié-Bitach, T., Johnson, C.A., Otto, E.A., Bhattacharya, S.S., Hildebrandt, F., Gibbs, R.A., Koenekoop, R.K., Swaroop, A., and Katsanis, N. (2009). A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. Nat Genet 41, 739-745 [Abstract]

Kim, J.Y., Duan, X., Liu, C.Y., Jang, M.H., Guo, J.U., Pow-anpongkul, N., Kang, E., Song, H., and Ming, G.L. (2009). DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63, 761-773 [Abstract]

McGrath, J.A., Avramopoulos, D., Lasseter, V.K., Wolyniec, P.S., Fallin, M.D., Liang, K.Y., Nestadt, G., Thornquist, M.H., Luke, J.R., Chen, P.L., Valle, D., and Pulver, A.E. (2009). Familiality of novel factorial dimensions of schizophrenia. Arch Gen Psychiatry 66, 591-600 [Abstract]

Johnson, A.W., Gallagher, M., and Holland, P.C. (2009). The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effects. J Neurosci 29, 696-704 [Abstract]


Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A.J., Makino, Y., Seshadri, A.J., Ishizuka, K., Srivastava, D.P., Xie, Z., Baraban, J.M., Houslay, M.D., Tomoda, T., Brandon, N.J., Kamiya, A., Yan, Z., Penzes, P., and Sawa, A. (2010). Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci 13, 327-332 [Abstract]

Niwa, M., Kamiya, A., Murai, R., Kubo, K., Gruber, A.J., Tomita, K., Lu, L., Tomisato, S., Jaaro-Peled, H., Seshadri, S., Hiyama, H., Huang, B., Kohda, K., Noda, Y., O'Donnell, P., Nakajima, K., Sawa, A., and Nabeshima, T. (2010). Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 65, 480-489 [Abstract]

Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K.L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I.N., Cadet, J.L., Pardo, C., Mori, S., Kamiya, A., Vogel, M.W., Sawa, A., Ross, C.A., and Pletnikov, M.V. (2010). Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry 68, 1172-1181 [Abstract]

Zaghloul, N.A., Liu, Y., Gerdes, J.M., Gascue, C., Oh, E.C., Leitch, C.C., Bromberg, Y., Binkley, J., Leibel, R.L., Sidow, A., Badano, J.L., and Katsanis, N. (2010). Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 107, 10602-10607 [Abstract]

Koh, M.T., Haberman, R.P., Foti, S., McCown, T.J., and Gallagher, M. (2010). Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 35, 1016-1025 [Abstract]


Ishizuka, K., Kamiya, A., Oh, E.C., Kanki, H., Seshadri, S., Robinson, J.F., Murdoch, H., Dunlop, A.J., Kubo, K., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M.D., Katsanis, N., and Sawa, A. (2011). DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 473, 92-96 [Abstract]

Brandon, N.J., and Sawa, A. (2011). Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 12, 707-722 [Abstract]

Kang, E., Burdick, K.E., Kim, J.Y., Duan, X., Guo, J.U., Sailor, K.A., Jung, D.E., Ganesan, S., Choi, S., Pradhan, D., Lu, B., Avramopoulos, D., Christian, K., Malhotra, A.K., Song, H., and Ming, G.L. (2011). Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron 72, 559-571 [Abstract]

Fallin, M.D., Lasseter, V.K., Liu, Y., Avramopoulos, D., McGrath, J., Wolyniec, P.S., Nestadt, G., Liang, K.Y., Chen, P.L., Valle, D., and Pulver, A.E. (2011). Linkage and association on 8p21.2-p21.1 in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 156, 188-197 [Abstract]

Ayhan, Y., Abazyan, B., Nomura, J., Kim, R., Ladenheim, B., Krasnova, I.N., Sawa, A., Margolis, R.L., Cadet, J.L., Mori, S., Vogel, M.W., Ross, C.A., and Pletnikov, M.V. (2011). Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry 16, 293-306 [Abstract]

Stranahan, A.M., Haberman, R.P., and Gallagher, M. (2011). Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats. Cereb Cortex 21, 392-400 [Abstract]


Golzio, C., Willer, J., Talkowski, M.E., Oh, E.C., Taniguchi, Y., Jacquemont, S., Reymond, A., Sun, M., Sawa, A., Gusella, J.F., Kamiya, A., Beckmann, J.S., and Katsanis, N. (2012). KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature 485, 363-367 [Abstract]

Kano, S., Colantuoni, C., Han, F., Zhou, Z., Yuan, Q., Wilson, A., Takayanagi, Y., Lee, Y., Rapoport, J., Eaton, W., Cascella, N., Ji, H., Goldman, D., and Sawa, A. (2012). Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry AOP [Abstract]

Taniguchi, Y., Young-Pearse, T., Sawa, A., and Kamiya, A. (2012). In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist 18, 169-179 [Abstract]

Ma, T.M., Abazyan, S., Abazyan, B., Nomura, J., Yang, C., Seshadri, S., Sawa, A., Snyder, S.H., and Pletnikov, M.V. (2012). Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol Psychiatry [Abstract]

Severance, E.G., Alaedini, A., Yang, S., Halling, M., Gressitt, K.L., Stallings, C.R., Origoni, A.E., Vaughan, C., Khushalani, S., Leweke, F.M., Dickerson, F.B., Yolken, R.H. (2012) Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res 138:48-53 [Abstract]

Severance, E.G., Kannan, G., Gressitt, K.L., Xiao, J., Alaedini, A., Pletnikov, M.V., and Yolken, R.H. (2012). Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice. PLoS One 7, e50991 [Abstract]


Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N., Kano, S., Ozaki, N., Nabeshima, T., Sawa, A. (2013). Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science, 339, 335-339 [Abstract]

Coughlin, J.M., Ishizuka, K., Kano, S.I., Edwards, J.A., Seifuddin, F.T., Shimano, M.A., Daley, E.L., Zandi, P.P., Leweke, F.M., Cascella, N.G., Pomper, M.G., Yolken, R.H., and Sawa, A. (2013). Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry 18, 10-11 [Abstract]