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COVID-19 Update

Studies currently recruiting

Ketamine Trial Research Study

Principal Investigator: Fernando Goes, M.D.; IRB00128515 

For more information about the research study, please contact the Research Coordinator at 410-614-1017.

We are looking for volunteers to participate in a ketamine trial research study. 

For inclusion in this study, the following will be required: 

  • Age 18-65 years 
  • Meets DSM-5 diagnostic criteria for major depressive disorder, bipolar I disorder, or bipolar II disorder
  • Has had a failure of at least two previous antidepressant or mood stabilizing treatments within the current depressive episode
  • Must not have prior participation in another study of ketamine for depression within the prior 6 months
  • Must not have active or unstable medical condition conferring too great a level of medical risk to allow inclusion in the study
  • Must not have used or abused of methamphetamine, cocaine, cannabis, or stimulants (prescribed and illicit) within the past 12 months

Further eligibility criteria will be given upon contact. 


MHi-GO: Mobile Health App for Tracking Mood Disorders Pilot Study

Principal Investigator: Peter Zandi, MPH, MHS, PhD; IRB00116741

Enrollment OPEN. 

For more information about participation in future studies, please call 410-550-1652.

We have developed a mobile phone app that allows us to help patients stay adherent to their treatments and to better track how they are doing clinically on these treatments so that we can provide more timely care that is responsive to the changing course of their illness.  We are currently conducting a pilot study of this mobile app to examine the feasibility and acceptability of using MHi-GO as part of routine care and to test whether its use improves medication adherence and course of illness.   

Oxidative Stress and Mood Disorder Trajectories Research Study

Principal Investigator: Fernando Goes, MD; IRB00104809

Enrollment is OPEN. 

For more information about the research study, please contact the Research Coordinator at 410-614-1017.

The long-term goal of the study is to understand biological mechanisms in the brain that contribute to a better or worse course of illness in mood disorder to inform the development of intervention and prevention strategies.
Depression is a common disorder, with one in five individuals experiencing an episode in their lifetime.  A history of depression is associated with a twofold increase in risk of dementia in later life. Thus, another goal of this project is to examine oxidative stress as a potential mechanism underlying increased risk of dementia in depression.

To Participate:

  • This research study will involve 2 study visits over a period of 2 weeks consisting of a blood draw, a urine tox screen, psychiatric evaluations, answering questionnaires and undergoing a scan of your brain called magnetic resonance imaging (MRI).
  • People aged 35-84 years with and without mood disorders may participate.
  • Psychiatric Evaluation: clinical measures to evaluate your psychiatric status
  • Questionnaires: Participants will complete several questionnaires and assessments to see how they use their memory and solve problems. Mood states and current health and medications will be recorded. 
  • Magnetic Resonance Imaging (MRI): Participants will have a 1-hour MRI scan done as part of this study at the second visit
  • Blood Draw: three 10mL blood samples will be taken from a vein in your arm
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