Print This Page
Share this page: More

Imaging Study of Lithium Response in Bipolar Disorder

Principal Investigator: Pamela Mahon, Ph.D.

(IRB Protocol # NA_00049892)

The primary objective of this study is to identify brain features that are associated with treatment response to lithium. 

Bipolar disorder is a serious mental illness. The treatment of choice for this disorder is the mood stabilizer lithium. However, responses vary greatly between patients with similar symptoms. While lithium is effective for some patients, others receive little benefit from lithium, and instead need to take other mood stabilizers.

Unfortunately, there are limited predictors to guide physicians in medication selections and many patients need weeks or even months of trial-and-error approach. 

Some of our other studies have taken a genetics approach to finding possible predictors of lithium response. This study will take an imaging approach to look for predictors of lithium response in brain structures.


This study will involve one three-hour visit and will consist of answering questionnaires and undergoing a scan of your brain called magnetic resonance imaging (MRI).
Questionnaires: Participants will complete several questionnaires and assessments to see how they use their memory and solve problems. Questionnaires will take approximately 60 minutes.
Magnetic Resonance Imaging (MRI): Participants will have an MRI scan done as part of this study. The MRI will take approximately 90 minutes.

For more information contact the Research Coordinator at 410-614-1017