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Dobrila Doda Rudnicki, Ph.D.

Adjunct Assistant Professor

Main Office Address

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Professional Interests



Selected Publications

Margolis RL and Rudnicki DD. Pathogenic insights from Huntington's disease-like 2 and other Huntington's disease genocopies. Current Opinion in Neurology, Curr Opin Neurol. 2016 Dec;29(6):743-748.

Li PP, Sun X, Xia G, Arbez N., Paul S, Zhu S, Peng B, Ross CA, Koeppen AH, Margolis RL, Pulst SM, Ashizawa T and Rudnicki DD. ATXN2-AS, a gene antisense to ATXN2, is associated with SCA2 and ALS. Ann Neurol. 2016 Oct;80(4):600-15. doi: 10.1002/ana.24761.

Sun X, Li PP, Zhu S, Cohen R, Marque LO, Ross CA, Pulst SM, Chan HY, Margolis RL, Rudnicki DD*. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci Rep., (2015), 5:12521. doi: 10.1038/srep12521. PMC4517393.

Sun X, Marque L, Cordner Z, Pruitt J., Bhat M, Li P, Kannan G, Ladenheim EE, Moran TH, Margolis RL and Rudnicki DD. Phosphorodiamidate Morpholino Oligomers (PMOs) suppress mutant huntingtin expression and attenuate neurotoxicity. Hum. Mol. Gen., (2014), 23(23):6302-17. PMID: 2503541910.1002/ajmg.b.32332. PMID: 26079385.

Seixas AI, Holmes SE, Takeshima H, Pavlovich A, Sachs N, Pruitt JL, Silveira I, Ross CA, Margolis RL and Rudnicki DD. Loss of junctophilin-3 contributes to Huntington's disease-like 2 pathogenesis. Ann Neurol, (2012), 71(2):245-57. PMID: 22367996.

Wilburn B, Rudnicki DD, Zhao J, Weitz TM, Cheng Y, Xiaofeng Gu X, Greiner E, Park CS, Wang N, Sopher B, La Spada AR, Alex Osmand A, Margolis R L, Sun YE and Yang XW. A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington's Disease-Like 2 (HDL2) Mice, Neuron , (2011), 12, 427-40. PMID: 21555070.

Rudnicki DD, Holmes SE, Lin MW, Thornton CA, Ross CA and Margolis R. Huntington's disease-like 2 is associated with CUG repeat-containing RNA foci. Ann Neurol , 2007, 61, 272-82. PMID: 17387722.