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Research Interests: Genetic and environmental risk factors for psychiatric disorders, brain development, stress, inflammation
Shiga University Hospital, Toyosato Hospital, Toyosato, Japan, 2000, Residency; Shiga University of Medical Science, Shiga, Japan, 2002, Staff Psychiatrist; Johns Hopkins University School of Medicine, Baltimore, Maryland, 2007, Psychiatry
The goal of our research is to understand the molecular mechanisms underlying etiopathophysiologies of psychiatric disorders, such as schizophrenia and depression. In particular, we investigate how genetic risk factors and environmental factors, such as adolescent cannabis use and psychosocial stress, affect stress-related biological signaling mechanisms, including immune and inflammatory processes, leading to impairment of brain maturation and of cognitive and emotional behaviors. Our work also extends to translational studies that investigate how altered inflammatory cascades are involved in other psychiatric conditions, such as delirium. We hope our research ultimately identifies new therapeutic targets for early intervention of these devastating conditions.
Lab Website: The Atsushi Kamiya Lab
Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, O., Okawa, M., Ross, C.A., Hatten, M.E., Nakajima, K., Sawa, A.: A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biol., 7; 1167-1178 (2005) (highlighted as "10 major breakthroughs in 2005 in Science 310: 1880-1885 2005")
Kamiya, A., Tan, P.L., Kubo, K., Engelhard, C., Ishizuka, K., Kubo, A., Tsukita, S., Pulver, A. E., Nakajima, K., Cascella, N. G., Katsanis, N., Sawa, A.: PCM1 is recruited to the centrosome by the cooperative action of DISC1 and BBS4 and is a candidate for psychiatric illness. Arch. Gen. Psychiatry 65; 996-1006 (2008)
Ballinger, MD., Saito, A., Abazyan, B., Taniguchi, Y., Huang, CH., Ito, K., Zhu, X., Segal, H., Jaaro-Peled., Sawa, A., Mackie, K., Pletnikov, MV., Kamiya, A.: Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory. Neurobiology of Disease 82; 176-184 (2015)
Saito, A., Taniguchi, Y., Rannals, M., Merfeld, EB., Ballinger, MD., Koga, M., Ohtani, Y., Gurley, DA., Sedlak, TW., Cross, A., Moss, SJ., Brandon, NJ., Maher, BJ., Kamiya, A.: Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Molecular Psychiatry (2016)
Saito, A., Taniguchi, Y., Kim, SH., Selvakumar, B., Perez, G., Ballinger, MD., Zhu, X., Sabra, J., Jallow, M., Yan, P., Ito, K., Rajendran, S., Hirotsune, S., Wynshaw-Boris, A., Snyder, SH., Sawa, A., Kamiya, A.: Developmental alcohol exposure impairs activity-dependent S-Nitrosylation of NDEL1 for neuronal maturation. Cerebral Cortex in press
Johns Hopkins University School of Medicine
Department of Psychiatry and Behavioral Sciences
Meyer Building
Baltimore, MD 21287
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