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School of Medicine
Shinichi Kano, M.D., Ph.D.
Assistant Professor of Psychiatry and Behavioral Sciences
Research Interests: Neuroimmunology; Brain disorders; Gene expression mechanisms; Intercellular communication.
Shinichi Kano is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences. Dr. Kano is a scientist with dual expertise in immunology and psychiatry. His research group investigates immune/inflammatory mechanisms underlying psychiatric disorders by using both human samples and model animals. The ultimate goal of Dr. Kano's research is to create a foundation for the development of novel therapeutic approaches for psychiatric disorders. Dr. Kano is an active member of the following scientific societies: American College of Neuropsychopharmacology (associate member), Society for Neuroscience (member), International Cytokine and Interferon Society (member), and International Society for Extracellular Vesicles (member).
- Assistant Professor of Psychiatry and Behavioral Sciences
Departments / Divisions
Centers & Institutes
- Molecular Psychiatry Program
- M.D., University of Tokyo (Japan) (2002)
- Ph.D., University of Tokyo (Japan) (2006)
University of Tokyo, Tokyo, Japan, 2007, Immunology; Johns Hopkins University School of Medicine, Baltimore, Maryland, 2014, Psychiatry
Research & Publications
We investigate CNS immunology and homeostasis in health and disease by using multidisciplinary approaches of neurobiology, immunology, and translational neuroscience. The ultimate goal of my research group is to discover fundamental concepts at the forefront of biology and develop new preventive/interventional treatment for chronic brain disorders and somatic disorders affecting CNS and immune system.
Lab Website: Shin-ichi Kano Lab
Technology Expertise KeywordsImmunology; Epigenetics; Glia; Extracellular vesicles; Psychiatric disorders
Kano S, Sato K, Morishita Y, Vollstedt S, Kim S, Bishop K, Honda K, Kubo M, Taniguchi T. The contribution of transcription factor IRF1 to the interferon-g-interleukin-12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. Nature Immunology. 2008;9(1):34-41.
Kano S, Nwulia E, Niwa M, Chen Y, Sawa A, Cascella N. Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. Neuroscience Research. 2011;71(3):289-93.
Kano S, Colantuoni C, Han F, Zhou Z, Yuan Q, Wilson A, Takayanagi Y, Lee Y, Rapoport J, Eaton W, Cascella N, Ji H, Goldman D, Sawa A. Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Molecular Psychiatry. 2013 Jul;18(7):740-2.
Kano S, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Horiuchi Y, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P, Sawa A, Kai M. Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. Current Molecuar Medicine. Curr Mol Med. 2015;15(2):138-45
Dohi E, Choi EY, Rose IVL, Murata AS, Chow S, Niwa M, Kano S. Behavioral changes in mice lacking interleukin-33. eNeuro. 2017;4(6) e0147-17.2017 1-15.
Activities & Honors
- Discovery Innovation Award, Johns Hopkins University School of Medicine, 2016
- Pathway to Independence Award (K99/R00), NIH, 2011
- International Cytokine and Interferon Society (ICIS), 2007
- Society for Neuroscience, 2008
- American College of Neuropsychopharmacology, 2016
- International Society for Extracellular Vesicles, 2017
Videos & Media
Recent News Articles and Media Coverage
Nosing Around a SZ Diagnosis, Hopkins Brain Wise, Winter 2014