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Rosanne Rouf, M.D.

Photo of Dr. Rosanne Rouf, M.D.
  • Director, Heart Failure Program
  • Assistant Professor of Medicine

Specializes in: Adults (18+ years), Geriatrics (55+ years)


Languages: English, Bengali


Cardiac Transplant, Cardiomyopathy, Cardiovascular Disease, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Critical Care Cardiology, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Inherited Heart Diseases, Peripartum Cardiomyopathy, Stress-induced Cardiomyopathy more

Research Interests

Genetic predisposition to cardiomyopathy and cardiotoxicity; nonmyocyte biology in heart failure; sex differences in cardiovascular disease more

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Johns Hopkins Bayview Medical Center

Appointment Phone: 443-997-0270
4940 Eastern Avenue
301 Building
Baltimore, MD 21224 map
Phone: 410-550-5337 | Fax: 410-550-1183


Rosanne Rouf, MD is Director of the Heart Failure Program at Johns Hopkins Bayview Medical Center and an Assistant Professor in the School of Medicine. Her basic and translational research programs focus on the role of nonmyocyte pathobiology and sex differences in heart failure development in both injury-induced and genetic cardiomyopathies. To perform this work, she uses preclinical models to test pharmacologic and gene-targeted strategies to either prevent or reduce the onset of cardiovascular disease. Clinically, she is an Advanced Heart Failure & Transplant cardiologist and sees heart failure patients at Johns Hopkins Bayview. She is a dedicated clinician and clinical educator who actively participates in training medical students, residents and fellows in heart failure and basic/clinical research.

Dr. Rosanne Rouf received her Bachelor's and Master's degrees in Electrical Engineering and Computer Science at Massachusetts Institute of Technology and her medical doctorate from Duke University School of Medicine. Following her Internal Medicine residency at Tufts Medical Center in Boston, she joined Johns Hopkins as an Adult Cardiology and Advanced Heart Failure/Transplant fellow and was a recipient of the prestigious American Heart Association Women in Cardiology Trainee Award in Excellence. After completing fellowship, Dr. Rouf joined the Johns Hopkins Advanced Heart Failure/Transplant faculty. She served as an attending physician on the inpatient Advanced Heart Failure/Transplant service at Johns Hopkins Hospital before being recruited to lead the Heart Failure Program at Johns Hopkins Bayview Medical Center. more


  • Director, Heart Failure Program
  • Assistant Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, Duke University School of Medicine (2002)


  • Tufts-New England Medical Center Hospitals / Internal Medicine (2005)


  • Johns Hopkins University School of Medicine / Cardiology (2010)

Research & Publications

Selected Publications

View all on Pubmed

Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, Ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC. Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan 2;124(1):448-60.

Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGFb signaling. Proceedings of the National Academy of Sciences. March 8, 2012.

Judge DP, Rouf R. Use of genetics in the clinical evaluation and management of heart failure. Current Treatment Options in Cardiovascular Medicine. December 2010; 12(6):566-77.

Houston BA, Vaishnav J, Schneider AL, Cromwell DM, Mille PE, Shah A, Sciortino C, Whitman G, Tedford RJ, Stevens GR, Judge DP, Russell SD, Rouf R. Angiotensin II Antagonism is Associated with Reduced Risk for Gastrointestinal Bleeding Due to Arteriovenous Malformations in Patients With Left Ventricular Assist Device. Journal of Heart and Lung Transplantation. 2017 Apr; 36(4):380-385.

Rouf R*, Macfarlane EG, Takimoto E, Chaudhary R, Nagpal V, Rainer PP, Bindman JG, Gerber EE, Bedja D, Schiefer C, Miller KL, Zhu G, Myers L, Amat-Alarcon N, Lee DI, Koitabashi N, Judge DP, Kass DA, Dietz HC*. Nonmyocyte ERK1/2signaling contributes to load-induced cardiomyopathy in Marfan mice. JCI Insight 2017; 2(15):doi: 10.1172/jci.insight.91588. *corresponding author.

Contact for Research Inquiries

Johns Hopkins University School of Medicine
720 Rutland Avenue
Ross 809
Baltimore, MD 21205 map

Activities & Honors


  • Stanley J. Sarnoff Scholar Award
  • Stanley L. Blumenthal Cardiology Research Award, First Prize in Basic Science
  • W. W. Smith Heart Award
  • International Congress of Human Genetics Young Investigator Award
  • Johns Hopkins University School of Medicine Clinician Scientist Award
  • Finalist, Northwestern Young Investigators Award, Junior Faculty Division
  • W. Leigh Thompson Excellence in Research Faculty Award
  • Discovery Innovation Award
  • Stanford Medicine X Global Research Challenge Finalist
  • Top Ten Research Highlights, Johns Hopkins Medicine
  • Johns Hopkins University Catalyst Award


  • American Heart Association
  • American Heart Association Council on Basic Cardiovascular Sciences

Professional Activities

  • Reviewer, Journal of Clinical Investigation
  • Reviewer, Circulation
  • Reviewer, Circulation Research
  • Reviewer, Circulation: Heart Failure
  • Reviewer, Journal of Cardiovascular Translational Research
  • Reviewer, Breast Cancer Research and Treatment

Videos & Media

Recent News Articles and Media Coverage

Research Group Targets Gender Disparities, Johns Hopkins Medicine (May 26, 2017)

Sex and Gender Aspects of Diseases and Health Across the Lifespan, Gender Med (July 16, 2017)

Research Group Keeps Focus on Women’s Health, Dome (July-August 2017)

Studying Women’s Health — to Improve It, Annual Report (July/August 2017)

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice, Medicine Matters (August 16, 2017)

Researchers reverse heart failure in Marfan mice, EurekaAlert, AAAS (November 14, 2017)

Heart failure reversed in Marfan mice, Science Daily (November 14, 2017)

Johns Hopkins researchers reverse heart failure in mice with Marfan syndrome, The Hub (November 16, 2017)

Researchers Reverse Heart Failure in Marfan Mice, Science and Technology Research News (November 16, 2017)

Rouf Receives Innovation Award, Medicine Matters (December 11, 2017)

Research Roundup (January-February 2018)

The Foundation for Gender-Specific Medicine—Our Researchers in Action, Gender Med (May 7, 2018)

Martin and Rouf Named Finalists of Nokia-Medicine X Digital Health Challenge, Medicine Matters (October 11, 2018)

Empowering heart failure patients with smart health devices, Stanford Medicine X (October 3, 2018)

33 early-career faculty members receive Johns Hopkins Catalyst Awards, The Hub (June 6, 2019)

Researchers from Johns Hopkins Kimmel Cancer Center Successfully Pilot Multidisciplinary Approach for Addressing Immunotherapy-Related Toxicities, Cision (June 18, 2019)

Three from the DOM Receive JHU Catalyst Awards, Medicine Matters (June 21, 2019)

How I Treat My Patients With Sacubitril/Valsartan for Heart Failure With Reduced Ejection Fraction, Cardiology Advisor (September 1, 2019)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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