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Dara L. Kraitchman, M.S., Ph.D., V.M.D.
Cardiovascular Interventional Section Head
Professor of Radiology and Radiological Science
Research Interests: Interventional magnetic resonance imaging (MRI) techniques for minimally invasive treatment; Development of labeling techniques for cell tracking and drug/protein delivery; Non-invasive imaging for early diagnosis and treatment of cardiovascular disease ...read more
Dr. Dara Kraitchman is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. Her research focuses on non-invasive imaging and minimally invasive treatment of cardiovascular disease. Dr. Kraitchman serves as the Cardiovascular Interventional Section Head within the department. Dr. Kraitchman is also co-Director of the Center for Image-Guided Animal Therapy (CIGAT), which provides state-of-the-art imaging and minimally invasive diagnostic and therapeutic options for pets as well as veterinary clinical trials.
The Kraitchman lab developed the first technique to provide radiopaque labeling of stem cells for x-ray fluoroscopic delivery and CT imaging of stem cell persistence for cardiac and peripheral arterial disease applications.
Dr. Kraitchman received her undergraduate degree in electrical engineering from Carnegie Mellon University. She earned her M.S.E. and Ph.D. in bioengineering from University of Pennsylvania. She also completed her V.M.D. in veterinary medicine from University of Pennsylvania. Dr. Kraitchman joined the Johns Hopkins faculty in 1996.
She is a Fellow of the American College of Cardiology and International Society for Magnetic Resonance in Medicine and a Distinguished Investigator in the Academy of Radiology.
- Cardiovascular Interventional Section Head
- Center for Image-Guided Animal Therapy Co-Director
- Professor of Radiology and Radiological Science
- Professor of Molecular and Comparative Pathobiology
Departments / Divisions
- Molecular and Comparative Pathobiology
- Radiology and Radiological Science - Magnetic Resonance Research
- B.S., Carnegie Mellon University (Pennsylvania) (1984)
- V.M.D., University of Pennsylvania (Pennsylvania) (1992)
- M.S., University of Pennsylvania (Pennsylvania) (1993)
- Ph.D., University of Pennsylvania (Pennsylvania) (1996)
- Veterinarian, Pennsylvania State Board of Veterinary Medicine (1992)
- Accredited Veterinarian, USDA-APHIS (1993)
- Veterinarian, Maryland State Board of Veterinary Medical Examiners (1996)
- Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, 1983, Electrical Engineering
- National Institute of Health, Bethesda, MD, 1997, Individual National Research Service Award Fellowship
Research & Publications
Dr. Kraitchman's research interests are concentrated on non-invasive imaging and minimally invasive treatment of cardiovascular disease. She has been actively involved in developing new methods to image myocardial function and perfusion using MRI. Current research interests are aimed at determining the optimal timing and method of administration of mesenchymal stem cells to regenerate infarcted myocardium using non-invasive MR fluoroscopic delivery and imaging. MRI and radiolabeling techniques include novel MR and radiotracer stem cell labeling methods to determine the location, quantity and biodistribution of stem cells after delivery as well as to noninvasively determine the efficacy of these therapies in acute myocardial infarction and peripheral arterial disease.
Recently, the first technique to provide radiopaque labeling of stem cells for x-ray fluoroscopic delivery and CT imaging of stem cell persistence for cardiac and peripheral arterial disease applications has been developed. These labeling techniques have been developed using FDA-approved contrast agents in large animal preclinical models of cardiovascular disease using clinical MR, radionuclide and CT imaging scanners for rapid translation to the clinical realm. She is also focused on the development of new animal models of human disease for noninvasive imaging studies and the development of promising new therapies in clinical trials for companion animals.
The Kraitchman lab concentrates on clinical translation of minimally invasive imaging technology that uses new molecular imaging and nanomedicine techniques to enable stem cell tracking and enhanced engraftment. Recent research efforts in the lab have concentrated on developing x-ray visible stem cells for cardiovascular applications. Using multimodality imaging techniques, the research team confirms stem cell viability with PET and bioluminescence. Then, using conventional devices currently in clinical trials, Kraitchman's researchers image and target stem cells to the heart directly using MRI fluoroscopy with a specialized MRI-compatible device or x-ray fluoroscopic imager.
Lab Website: Dara Kraitchman Laboratory
Technology Expertise KeywordsStem cell, veterinary imaging, cardiovascular, MRI, CT, PET, SPECT
Clinical Trial Keywordsobesity embolization interventional radiology
veterinary clinical trials
Selected PublicationsView all on Pubmed
Krimins R, Fritz J,Gainsburg L, Gavin P, Ihms EZ, Huso DL, Kraitchman DL. MR-Guided bone biopsy of a T11 vertebral body mass in a Rottweiler. J Amer Vet Med Assoc,2017 250(7):779-784
Weiss, CR, Akinwande O, Paudel K, Cheskin LJ, Holly B, Hong K, Fischman AM, Patel RS, Shin EJ, Steele KE, Moran TH, Kaiser K, Park A, Shade DM, Kraitchman DL, Arepally A. Clinical safety of bariatric arterial embolization: Preliminary results of the BEAT Obesity Trial, Radiology.2017 May;283(2):598-608.
Kraitchman D, Kamel I, Weiss C and Georgiades C. Elucidation of percutaneously accessible lymph nodes in swine: A large animal model for interventional lymphatic research. J Vasc Interv Radiol. 2017; 28:451–456
Lauer AM, El-Sharkawy AM, Kraitchman DL, Edelstein WA. "MRI acoustic noise can harm experimental and companion animals." J Magn Reson Imaging. 2012 Sep;36(3):743-7. doi: 10.1002/jmri.23653.
Fu Y, Azene N, Ehtiati T, Flammang A, Gilson WD, Gabrielson K, Weiss CR, Bulte JW, Johnston PV, Kraitchman DL :X-ray fusion with magnetic resonance image-guidance of intrapericardial delivery of microencapsulated human mesenchymal stem cells in immunocompetent swine. Radiology, 2014 272(2):427-437.
Activities & Honors
- Distinguished Investigator, Academy of Radiology Research, 2012
- Fellow, American College of Cardiology, 2008
- Best Oral Abstract, Third place, Society of Cardiovascular Magnetic Resonance, 2003
- Society of Computed Body Tomography and MR Contrast Award, 2000
- Fellow, International Society for Magnetic Resonance in Medicine, 2015
- Affiliate Faculty in Institute for Computation Medicine
- Affiliate Faculty in Institute of Nanobiotechnology
- American Heart Association
- American Veterinary Medical Association
- Fellow of American College of Cardiology
- Institute of Electrical and Electronics Engineers
- International Society for Magnetic Resonance in Medicine
- Society of Cardiovascular Magnetic Resonance
Videos & Media
Recent News Articles and Media Coverage
One Health Company balances improving biomedical research and ethical animal testing, MedCity News (July 8, 2017)
Johns Hopkins begins using high-tech equipment on pets, The Baltimore Sun (April 14, 2015)
New Johns Hopkins University Center Brings Imaging Therapies To Pets, Johns Hopkins Medicine (March 16, 2015)
The Dog and Cat Wing: Hospital Sets Up a Scanner Center for Pets, Scientific American (January 20, 2015)
Human tech helping treat pets' pain, WBAL Baltimore (July 16, 2015)
Otter the Labrador Retriever Gets an MRI, The Baltimore Sun (April 7, 2015)
Johns Hopkins Offers Top-Of-The-Line Care For Pets, CBS Baltimore (March 19, 2015)