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Lyle Wilfred Ostrow, M.D., Ph.D.

Photo of Dr. Lyle Wilfred Ostrow, M.D., Ph.D.

Assistant Professor of Neurology


Expertise: Amyotrophic Lateral Sclerosis (ALS), Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD), Muscular Dystrophies, Myasthenia Gravis, Myopathy, Neurology, Neuromuscular Pathology, Peripheral Neuropathies more

Research Interests: The role of astrocytes in ALS

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The Johns Hopkins Hospital


600 N. Wolfe Street The John G. Rangos Sr. Building Suite 248 Baltimore, MD 21287 map

Phone: 410-502-6165 | Fax: 410-502-5459


Dr. Lyle Ostrow sees patients with a broad range of diseases of nerve and muscle, including amyotrophic lateral sclerosis (ALS), chronic inflammatory polyneuropathy (CIDP), peripheral neuropathies, muscular dystrophies and myopathies, myositis, and myasthenia gravis.

Dr. Ostrow's laboratory research focuses on the role of astrocytes in amyotrophic lateral sclerosis (ALS) and other neurologic disorders. He is investigating whether abnormally increased production of a protein called endothelin by astrocytes may represent a novel therapeutic target in ALS. He also studies ways in which astrocytes sense and respond to mechanical stress, and how this may be involved in several neurologic diseases.

Dr. Lyle Ostrow received his M.D. degree and a Ph.D. in Biophysics from the State University of New York at Buffalo. He completed an Internal Medicine Internship at Johns Hopkins Bayview Medical Center, followed by Neurology Residency training at The Johns Hopkins Hospital. After residency, Dr. Ostrow completed a fellowship in Neuromuscular Medicine also at Johns Hopkins. more


  • Assistant Professor of Neurology

Departments / Divisions



  • MD PhD, SUNY at Buffalo School of Medicine (2005)


  • Johns Hopkins University School of Medicine / Neurology (2009)


  • Johns Hopkins University School of Medicine / Neuromuscular Medicine (2010)

Board Certifications

  • American Board of Psychiatry And Neurology / Neurology (2009)

Research & Publications

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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