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Geraldine Seydoux, Ph.D.

Photo of Dr. Geraldine Seydoux, Ph.D.
  • Huntington Sheldon Professor in Medical Discovery
  • Professor of Molecular Biology and Genetics

Research Interests

RNA granules; phase transition; intrinsically-disordered proteins; genome engineering

Background

Dr. Geraldine Seydoux is the Huntington Sheldon Professor in Medical Discovery in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and an investigator with the Howard Hughes Medical Institute. Her work examines how early embryos develop into complex asymmetric structures comprising many cell types.

The Seydoux lab studies how single-cell embryos localize RNAs and proteins to pattern developmental potential.  Currently, the lab is studying a new class of intrinsically-disordered proteins that scaffold RNA granules and regulate germ cell fate. The lab has also characterized an efficient, homology-dependent DNA repair pathway and developed methods for genome engineering.  

Dr. Seydoux received her B.S. in biochemistry from the University of Maine at Orono in 1986, and completed her Ph.D. in molecular biology at Princeton University in 1991. After a postdoctoral fellowship in developmental biology at the Carnegie Institute of Washington, she joined the faculty of Johns Hopkins in 1995 as an assistant professor. She became an associate professor in 2000, and a full professor in 2005.

Dr. Seydoux's work has garnered several awards, including a MacArthur Fellowship in 2001. She was elected to the American Academy of Arts and Sciences in 2013 and to the National Academy of Sciences in 2016. She assumed the role of vice dean for Basic Research at the Johns Hopkins School of Medicine in 2017.

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Titles

  • Huntington Sheldon Professor in Medical Discovery
  • Vice Dean for Basic Research
  • Professor of Molecular Biology and Genetics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., Princeton University (New Jersey) (1991)
  • B.S., University of Maine (Maine) (1986)

Additional Training

Carnegie Institute of Washington, Washington, D.C., 1995, Developmental Biology

Research & Publications

Research Summary

Geraldine Seydoux is a developmental biologist who studies how early embryos develop into complex asymmetric structures comprising many cell types. Geraldine uses the transparent worm C. elegans as a model system and has developed methods to film and measure protein dynamics in live embryos.

Lab Website: Seydoux Lab

Selected Publications

View all on Pubmed

Lee, CY, Lu, T. Seydoux, G. 2017 Specification of the germline by Nanos-dependent down-regulation of the somatic synMuvB transcription factor LIN-15B. eLife, Elife. 2016 Dec 3;5. pii: e21337. doi: 10.7554/eLife.21337

Paix, A., Folkmann, A., Goldman, D., Kulaga H., Grzelak M., Rasoloson D., Paidemarry S., Green R., Reed R., Seydoux, G. 2017 Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. PNAS, 2017 Nov 28. pii: 201711979. doi: 10.1073/pnas.1711979114

Ouyang, JPT, Folkmann, A, Bernard, L, Lee, CY, Seroussi, U, Charlesworth, AG et al.. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Dev. Cell. 2019;50 (6):716-728.e6. doi: 10.1016/j.devcel.2019.07.026. PubMed PMID:31402283 PubMed Central PMC6764750

Putnam, A, Cassani, M, Smith, J, Seydoux, G. A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos. Nat. Struct. Mol. Biol. 2019;26 (3):220-226. doi: 10.1038/s41594-019-0193-2. PubMed PMID:30833787 PubMed Central PMC6668929

Seydoux, G. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. J. Mol. Biol. 2018;430 (23):4702-4710. doi: 10.1016/j.jmb.2018.08.007. PubMed PMID:30096346

Contact for Research Inquiries

725 N. Wolfe Street
706 PCTB
Baltimore, MD 21205 map
Phone: 410-614-4622
Fax: 410-955-9124

Email me

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program

Human Genetics and Molecular Biology

Courses and Syllabi

  • Molecules and Cells, (Instructor)
    1996
  • Fundamentals of Genetics, (Instructor)
    1997
  • Development Biology Elective, (Instructor)
    2004
  • Epigenetics Elective, (Instructor)
    2004
  • Fundamentals of Genetics, (Course Director)
    2003

Activities & Honors

Honors

  • Election to the National Academy of Sciences, NAS
  • MacArthur Fellowship, 2001
  • Presidential Early Career Award for Scientists and Engineers (PECASE), National Institutes of Health, 1999
  • Kirsch Investigator Award, Steve and Michele Kirsch Foundation, 2001 - 2003
  • Searle Scholar Program, The Chicago Community Trust, 1996
  • David and Lucile Packard Fellowship for Science and Engineering, 1995
  • Helen Hay Whitney Post-Doctoral Fellowship, 1991
  • Howard Hughes Medical Institute Pre-Doctoral Fellowship, 1988
  • Princeton Fellowship, 1986

Memberships

  • American Society for Cell Biology
  • Genetic Society of America
  • Society for Developmental Biology

Professional Activities

  • Admissions Committee BCMB graduate program, Johns Hopkins University, 1997
  • Review Panel, Life Sciences Research Foundation, 2005
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