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Ling He, M.D., Ph.D.

Photo of Dr. Ling He, M.D., Ph.D.
  • Associate Professor of Pediatrics

Expertise

Neonatal-Perinatal Medicine

Background

Dr. Ling He is an associate professor of pediatrics and pharmacology at the Johns Hopkins University School of Medicine. His research focuses on metabolism. 

Dr. He earned his M.D. from Third Military Medical University in Chongqin, China, and his Ph.D. from the University of Arkansas for Medical Sciences. 

His work has been recognized with awards from the Accelerated Translational Incubator Pilot (ATIP) Program and the Johns Hopkins-University of Maryland Diabetes Research Center (DRC) Pilot and Feasibility (P and F) Program.

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Titles

  • Associate Professor of Pediatrics
  • Associate Professor of Pharmacology and Molecular Sciences

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., University of Arkansas for Medical Sciences College of Medicine (Little Rock) (Arkansas) (2007)
  • M.D., Third Military Medical University - Chongqing (China) (1988)

Research & Publications

Research Summary

Ling He’s research focuses on liver metabolism, in particular, glucose and lipid metabolism and the involvement of mitochondrial dynamics. Currently, his laboratory is working on an NIH-funded project to define the molecular mechanisms of metformin’s effects on mitochondrial dynamics and respiration through AMPK activation. He has another NIH-funded project to investigate mechanisms leading to the paradoxical concurrence of insulin resistance and hepatic steatosis in obesity. In addition, his laboratory is studying the mechanisms responsible for the mitochondrial expansion in neonates.

Selected Publications

View all on Pubmed

Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Reports 2019 Nov 5;29(6):1511-1523.e5. doi: 10.1016/j.celrep.2019.09.070. PMID:31693892

Cao J, Peng J, An H, He Q, BoroninaT, GuoS, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nature Communications 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w. PubMed PMID: 28743992; PubMed Central PMCID: PMC5526866.

He L, Wondisford FE. Metformin action: concentrations matter. Cell Metabolism 2015 Feb 3;21(2):159-162. doi: 10.1016/j.cmet.2015.01.003. PubMed PMID: 25651170.

He L, Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell. 2009 May 15;137(4):635-46. doi: 10.1016/j.cell.2009.03.016. PubMed PMID: 19450513; PubMed Central PMCID: PMC2775562.

He L, SimmenFA, MehendaleHM, RonisMJ, Badger TM. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. Journal of Biological Chemistry 2006 Apr 21;281(16):11126-34. doi: 10.1074/jbc.M510724200. Epub2006 Feb 1. PubMed PMID: 16452480.

Contact for Research Inquiries

Johns Hopkins Hospital
600 N. Wolfe Street
Department of Pediatrics, CMSC10-113
Baltimore, MD 21287 map
Phone: 410-502-5765

Email me

Activities & Honors

Honors

  • Pilot and Feasibility (P and F) Program Award, JHU-UMD Diabetes Research Center
  • Accelerated Translational Incubator Pilot (ATIP) Program Award, The Johns Hopkins Institute for Clinical and Translational Research
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