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Eric Hutton Raabe, M.D., Ph.D.
Associate Professor of Oncology
Languages: English, French
Expertise: Brain Cancer, Medical Oncology, Pediatric Oncology
Research Interests: Targeting stem cell factors and their downstream effectors in malignancy, specifically in brain tumors; using human neural stem cells to create genetically accurate models of aggressive brain tumors; disrupting the LIN28 pathway in brain tumors; developing novel metabolic-based therapies to disrupt MYC-driven tumors ...read more
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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287 map
Eric Raabe, M.D., Ph.D., is an assistant professor of oncology and an instructor of pathology at Johns Hopkins School of Medicine.
Dr. Raabe majored in neural science at Brown University and received his M.D. and Ph.D. from the University of Cincinnati College of Medicine. He completed his pediatric internship and residency at Children’s Hospital of Philadelphia.
After spending a year working in Africa as part of the Baylor International Pediatric AIDS Initiative, Dr. Raabe joined Johns Hopkins as a pediatric oncology fellow. Working in the laboratory of Charles Eberhart in Neuropathology, Dr. Raabe established a human neural stem cell system to create genetically accurate models of pediatric brain tumors.
With an interest in neuro-oncology, Dr. Raabe see patients in the pediatric oncology outpatient clinic at Johns Hopkins.
He continues his research in the new Smith Building of the Wilmer Eye Institute in the Neuropathology Division, in collaboration with Charles Eberhart.
- Associate Professor of Oncology
- Instructor of Pathology
- MD, University of Cincinnati College of Medicine (2003)
- Children's Hospital of Philadelphia / Pediatrics (2006)
- Johns Hopkins University School of Medicine / Pediatric Oncology (2011)
- American Board of Pediatrics / Pediatric Hematology-Oncology (2011)
- American Board of Pediatrics / Pediatrics (2008)
Research & Publications
Dr. Raabe’s research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor prognosis brain tumors. Dr. Raabe’s expertise is in stem cell biology, developmental biology and pre-clinical therapeutics. He has generated one of a handful of human diffuse intrinsic pontine glioma cell lines that form xenografts with high fidelity to the primary tumor and retain the H3F3A K27M mutation. He has expertise in targeting stem cell factors in aggressive brain tumors in vivo and in vitro. Dr. Raabe has developed normal human and mouse neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors.
Dr. Raabe currently has a research group composed of research assistants, graduate students, and post-doctoral fellows. He continues to work closely with Dr. Charles Eberhart, who is a neuro-pathologist and core collaborator.
Lab Website: Eberhart, Rodriguez and Raabe Lab
Selected PublicationsView all on Pubmed
Mao, XG, Hutt-Cabezas, M, Orr, BA, Weingart, M, Taylor I, Rajan K, Odia Y, Kahlert U, Maciaczyk J, Nikkhah G, Eberhart CG*, Raabe EH*. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumor formation by enacting a pro-invasive genetic program. Oncotarget. 2013 Jul;4(7):1050-64. PMCID 3759665 * Co-corresponding author.
Kaur H, Ali SZ, Huey L, Hutt-Cabezas M, Taylor I, Mao XG, Weingart M, Chu Q, Rodriguez FJ, Eberhart CG, Raabe EH. The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma. Cancer Lett. 2016 Jul 10; 377(1):55-64. doi: 10.1016/j.canlet.2016.04.020. Epub 2016 Apr 18. PMID: 27102002
Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, Schreiber SL, Fraenkel E, Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG*, Raabe EH*. DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clin Cancer Res. 2016 Mar 24. PMID: 27012813. * Co-corresponding author.
Weingart MF, Roth J, Hutt-Cabezas M , Busse T , Kaur H, Price A, Maynard R, Rubens J, Taylor I , Mao XG, Xu J, Kuwahara Y, Allen SJ , Erdreich-Epstein A, Weissman BE , Orr BA , Eberhart CG, Biegel J, Raabe EH. Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target. Oncotarget, 2015 Feb 20;6(5):3165-77. PMCID: PMC4413645
Raabe, E.H., Lim, K.S., Kim, JM., Meeker, A., Mao, XG., Nikkhah, G., Macizczyk, J., Kahlert, U., Jain, D., Bar, E., Cohen, KJ, Eberhart CG. "BRAF Activation Induces Transformation and then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model." Clinical Cancer Research, (2011) Jun 1;17(11):3590-9. PMCID: PMC4086658
Activities & Honors
- Alpha Omega Alpha, University of Cincinnati College of Medicine, 2002
- Award Winner, St. Baldrick’s Fellowship, 2008
- Francis Schwentker Award for Excellence in Research by Pediatrics House Staff and Fellows, Johns Hopkins Hospital, 2011
- American Association for Cancer Research, 2008
- Children's Oncology Group, 2013
- Sigma Xi, 1993
- Society for Neuro-oncology, 2012
Videos & Media
Lectures and Presentations
Francis Schwentker Address
Pediatrics Grand Round, Baltimore, MD (05/01/2011)
Johns Hopkins Children's Center
Recent News Articles and Media Coverage
Going After the Big Bad Tumor 6/11/13
Stem Cells May Speed Up Screening of Drugs for Rare Cancers, Johns Hopkins Medicine (August 1, 2016)