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Eric Charles Frey, Ph.D.

Photo of Dr. Eric Charles Frey, Ph.D.
  • Professor of Radiology and Radiological Science


Dr. Eric Charles Frey is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science and Department of Oncology. He specializes in medical imaging physics and is a member of the Johns Hopkins Kimmel Cancer Center.

Dr. Frey received his B.S. in physics from Davidson University in 1981, and his Ph.D., also in physics, from the University of North Carolina at Chapel Hill in 1989. After a postdoctoral fellowship in radiology at the University of North Carolina at Chapel Hill, he joined the staff of the Department of Biomedical Engineering there. He joined the faculty of Johns Hopkins in 2007.

His research focuses on techniques and uses for single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging and reconstruction to solve medical problems in cardiology, oncology and neurology. He has published more than 100 peer-reviewed research articles and several book chapters on various aspects of medical imaging and tomography. He has been awarded numerous grants in the field and has served on a variety of boards and committees. more


  • Professor of Radiology and Radiological Science
  • Professor of Oncology

Departments / Divisions

Centers & Institutes



  • Ph.D., University of North Carolina (Chapel Hill) (North Carolina) (1989)
  • B.S., Davidson College (North Carolina) (1981)

Additional Training

University of North Carolina at Chapel Hill, Chapel Hill, NC, 1990, Radiology

Research & Publications

Research Summary

Dr. Frey’s current research projects include: developing and evaluating improved quantitative imaging for targeted radionuclide cancer therapy treatment planning; developing and validating multi-modality (PET/CT, SPECT/CT, and MRI) quantitative imaging metrics for assessment of response to cancer therapy; developing, optimizing and validating simultaneous dual isotope SPECT methods for assessing rest-stress myocardial perfusion and myocardial perfusion-innervation mismatch; optimizing pediatric nuclear medicine procedures to optimize dose while maintaining adequate diagnostic image quality; and optimizing instrumentation, acquisition, and reconstruction methods and parameters for myocardial perfusion SPECT.


Dr. Frey’s laboratory develops new techniques for single and multiple isotope SPECT imaging and reconstruction for myocardial perfusion, brain neuroreceptor, and radioimmunotherapy treatment planning. He also has developed systems and algorithms for small animal microcomputed tomography using conventional and photon counting detectors.

Selected Publications

Y.K. Dewaraja, E.C. Frey, G. Sgouros, A. B. Brill, P. Roberson, P.B. Zanzonico, and M. Ljungberg. "MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy." Accepted for publication in the J Nucl Med.

X. Rong, Y. Du, and E.C. Frey. "Optimization of energy windows for quantitative tasks including the effects of model mismatch: application to 90Y bremsstrahlung SPECT imaging." Phys Med Biol. 23; 57(12): 3711-3725, submitted automatically by publisher to PMC.

X. Rong, Y. Du, M. Ljungberg, E. Rault, S Vandenberghe, E.C. Frey. "Development of an improved quantitative 90Y bremsstrahlung SPECT method," Med Phys. 39(5): 2346-58, 2012, PMC3338590.

E.C. Frey, J.L. Humm, and M. Ljungberg. "Accuracy and precision of radioactivity quantification in nuclear medicine images." Sem Nucl Med. 42(3), 208-218, 2012, submitted automatically by publisher to PMC.

S. Senthamizhchelvan, R.F. Hobbs, H. Song, E.C. Frey, Zhe Zhang, E Armour, R.L. Wahl, D.M. Loeb, and G. Sgouros. "Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acide therapy of high-risk osteosarcoma." J Nucl Med. 53(2), 215-224, 2012, PMC3291096.

Contact for Research Inquiries

Phone: 443-287-2426

Activities & Honors


  • American Association for Physicists in Medicine
  • American Physical Society
  • European Association for Nuclear Medicine
  • Institute for Electronics and Electrical Engineers
  • International Society for Optical Engineering (SPIE)
  • Society for Industrial and Applied Mathematics
  • Society for Nuclear Medicine
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