Dr. Frey’s current research projects include: developing and evaluating improved quantitative imaging for targeted radionuclide cancer therapy treatment planning; developing and validating multi-modality (PET/CT, SPECT/CT, and MRI) quantitative imaging metrics for assessment of response to cancer therapy; developing, optimizing and validating simultaneous dual isotope SPECT methods for assessing rest-stress myocardial perfusion and myocardial perfusion-innervation mismatch; optimizing pediatric nuclear medicine procedures to optimize dose while maintaining adequate diagnostic image quality; and optimizing instrumentation, acquisition, and reconstruction methods and parameters for myocardial perfusion SPECT.
Dr. Frey’s laboratory develops new techniques for single and multiple isotope SPECT imaging and reconstruction for myocardial perfusion, brain neuroreceptor, and radioimmunotherapy treatment planning. He also has developed systems and algorithms for small animal microcomputed tomography using conventional and photon counting detectors.
Y.K. Dewaraja, E.C. Frey, G. Sgouros, A. B. Brill, P. Roberson, P.B. Zanzonico, and M. Ljungberg. "MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy." Accepted for publication in the J Nucl Med.
X. Rong, Y. Du, and E.C. Frey. "Optimization of energy windows for quantitative tasks including the effects of model mismatch: application to 90Y bremsstrahlung SPECT imaging." Phys Med Biol. 23; 57(12): 3711-3725, submitted automatically by publisher to PMC.
X. Rong, Y. Du, M. Ljungberg, E. Rault, S Vandenberghe, E.C. Frey. "Development of an improved quantitative 90Y bremsstrahlung SPECT method," Med Phys. 39(5): 2346-58, 2012, PMC3338590.
E.C. Frey, J.L. Humm, and M. Ljungberg. "Accuracy and precision of radioactivity quantification in nuclear medicine images." Sem Nucl Med. 42(3), 208-218, 2012, submitted automatically by publisher to PMC.
S. Senthamizhchelvan, R.F. Hobbs, H. Song, E.C. Frey, Zhe Zhang, E Armour, R.L. Wahl, D.M. Loeb, and G. Sgouros. "Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acide therapy of high-risk osteosarcoma." J Nucl Med. 53(2), 215-224, 2012, PMC3291096.