In the Laboratory for Neurocognitive and Imaging Research (LNIR), Dr. Mostofsky investigates the biological bases of developmental disorders using both structural and functional imaging techniques and experimental neurobehavioral paradigms, including motor/oculomotor and cognitive testing. These methods are used to improve our understanding of the neurologic basis of autism and ADHD. This work has been supported by grants from the NIH (NINDS and NIMH) and the Autism Speaks Foundation.
Dr. Mostofsky’s research with children with autism is focused on careful examination of the motor function, as increased insight into the brain mechanisms underlying the disorder might be gained from careful consideration of the motor signs associated with autism. Dr. Mostofsky has made important contributions to identifying the common factors underlying motor impairments in autism and has begun to understand how anomalous patterns of motor learning in autism may contribute to the impaired social and communicative deficits that define the disorder.
Dr. Mostofsky is also working to pinpoint the neural systems affected in ADHD and to help identify mechanisms for effective therapeutic intervention. This investigative work has led to important insights into how impairments in response selection and control (of behavior ranging from basic motor execution to higher level cognition) contribute to the excessive impulsive, hyperactive, and off-task ("distractible") behavior.
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Precentral gyrus functional connectivity signatures of autism. Nebel MB, Eloyan A, Barber AD, Mostofsky SH. Front Syst Neurosci. 2014 May 14;8:80. doi: 10.3389/fnsys.2014.00080. eCollection 2014. PMID: 24860442
Reduction of motion-related artifacts in resting state fMRI using aCompCor. Muschelli J, Nebel MB, Caffo BS, Barber AD, Pekar JJ, Mostofsky SH. Neuroimage. 2014 Mar 18;96C:22-35. doi: 10.1016/j.neuroimage.2014.03.028. [Epub ahead of print] PMID: 24657780
Analytic programming with FMRI data: a quick-start guide for statisticians using R. Eloyan A, Li S, Muschelli J, Pekar JJ, Mostofsky SH, Caffo BS. PLoS One. 2014 Feb 28;9(2):e89470. doi: 10.1371/journal.pone.0089470. eCollection 2014. PMID: 24586801
Impaired tactile processing in children with autism spectrum disorder. Puts NA, Wodka EL, Tommerdahl M, Mostofsky SH, Edden RA. J Neurophysiol. 2014 May;111(9):1803-11. doi: 10.1152/jn.00890.2013. Epub 2014 Feb 12. PMID: 24523518
The NIH Toolbox Cognition Battery: results from a large normative developmental sample (PING). Akshoomoff N, Newman E, Thompson WK, McCabe C, Bloss CS, Chang L, Amaral DG, Casey BJ, Ernst TM, Frazier JA, Gruen JR, Kaufmann WE, Kenet T, Kennedy DN, Libiger O, Mostofsky S, Murray SS, Sowell ER, Schork N, Dale AM, Jernigan TL. Neuropsychology. 2014 Jan;28(1):1-10. doi: 10.1037/neu0000001. Epub 2013 Nov 11. Erratum in: Neuropsychology. 2014 Mar;28(2):319. PMID: 24219608