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Mikhail V. Pletnikov, M.D., Ph.D.

Photo of Dr. Mikhail V. Pletnikov, M.D., Ph.D.

Professor of Psychiatry and Behavioral Sciences

Research Interests: Molecular, cellular and system mechanisms of abnormal brain development and gene-environment interactions relevant to major schizophrenia and autism more



  • Professor of Psychiatry and Behavioral Sciences
  • Professor of Molecular and Comparative Pathobiology
  • Professor of Neuroscience

Departments / Divisions



  • M.D., I.M. Sechenov Moscow Medical Academy - Moscow (Russia) (1986)
  • Ph.D., P.K. Anokhin Institute of Normal Physiology (Russia) (1990)

Additional Training

Johns Hopkins University School of Medicine, Baltimore, MD, 1999

Research & Publications

Lab Website: Mikhail Pletnikov Laboratory
Core Facility: MRB Behavior Core

Selected Publications

Kannan G, Pletnikov MV. Toxoplasma Gondii and Cognitive Deficits in Schizophrenia: An Animal Model Perspective. Schizophr Bull. 2012 Sep 1. [Epub ahead of print]

Ma TM, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, Sawa A, Snyder SHPletnikov MV. Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol Psychiatry. 2012 Jul 17. doi: 10.1038/mp.2012.97. [Epub ahead of print]

Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov , Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, Sawa A, Ross CA, Pletnikov MV. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry. 2010 Dec 15;68(12):1172-81. Erratum in: Biol Psychiatry. 2011 Feb 15;69(4):390.

Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova IN, Sawa A, Margolis RL, Cadet JL, Mori S, Vogel MW, Ross CA, Pletnikov MV. Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry. 2011 Mar;16(3):293-306.

Ayhan Y, Sawa A, Ross CA, Pletnikov MV. Animal models of gene-environment interactions in schizophrenia. Behav Brain Res. 2009 Dec 7;204(2):274-81.

Contact for Research Inquiries

The Johns Hopkins University School of Medicine
600 North Wolfe Street
CMSC 8-117
Baltimore, MD 21287 map
Phone: 410-502-3760

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