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Matthew John Weiss, M.D.

4.9 out of 5
145 Ratings
Photo of Dr. Matthew John Weiss, M.D.

Surgical Director, Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics

Associate Professor of Surgery


Expertise: Bile Duct Cancer, Bile Duct Disease, Bile Duct Surgery, Biliary Tract Surgery, Colorectal Metastases to the Liver, Distal Pancreatectomy, Gallbladder Cancer, Gastric Cancer, Gastrointestinal Cancers, Gastrointestinal Diseases, Gastrointestinal Tumors, General Surgery, Hepatic Surgery, Hepatobiliary Disease, Hepatobiliary Malignancies, Hepatobiliary Surgery, Hepatocellular Cancer, Hepatopancreatobiliary Surgery, Irreversible Electroporation, Klatskin Tumors, Laparoscopic Gallbladder Surgery, Laparoscopic Liver Surgery, Laparoscopic Pancreas Surgery, Liver Cancer, Liver Cysts, Liver Tumors, Minimally Invasive Surgery, Neuroendocrine Tumors, Pancreatic Cancer, Pancreatic Cysts, Pancreatic Disease, Pancreatic Surgery, Pancreatic Tumors, Pancreaticoduodenectomy, Robotic Bilary Surgery, Robotic Liver Surgery, Robotic Pancreas Surgery, Stomach Cancer, Surgical Oncology, Von Hippel-Lindau (VHL), Whipple Procedure more

Research Interests: Examining the outcomes following the utilization of minimally invasive and robotic surgery in pancreatic and liver surgery more

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The Johns Hopkins Hospital
Appointment Phone: 410-933-7262

600 N. Wolfe Street
Halsted 614
Baltimore, MD 21287 map
Phone: 410-614-3368
Fax: 443-769-1276


Matthew Weiss, MD, FACS, specializes in surgery for pancreatic and liver cancer, as well as benign hepatopancreatobiliary diseases, including cystic lesions of the pancreas. In addition to performing the Whipple procedure, he has particular expertise in minimally invasive pancreatic resections. Dr. Weiss' clinical interests also include colorectal metastases to the liver, hepatocellular carcinomas, intrahepatic cholangiocarcinomas, bile duct cancers (Klatskin tumors), intraductal papillary mucinous neoplasms of the pancreas, neuroendocrine tumors, and gallbladder cancers.

His research interests include the examining the outcomes following the utilization of minimally invasive and robotic surgery in pancreatic and liver surgery. He is a member of the American College of Surgeons, the Society of Surgical Oncology, the American Hepato-Pancreato-Biliary Association, and the Association for Academic Surgery. more


  • Surgical Director, Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics
  • Director, Complex Surgical Oncology Fellowship Program, Johns Hopkins Medicine
  • Surgical Director, Johns Hopkins Liver Cancer Multidisciplinary Clinic
  • Associate Professor of Surgery
  • Associate Professor of Oncology

Departments / Divisions



  • MD, Jefferson Medical College of Thomas Jefferson University (2003)


  • Johns Hopkins University School of Medicine / Surgery (2010)


  • Memorial Sloan-Kettering Cancer Center / Oncology (2012)

Board Certifications

  • American Board of Surgery / Surgery (2010)

Activities & Honors


  • American Hepatopancreatobiliary Association-Member
  • American College of Surgeons-Fellow
  • Society of Surgical Oncology
  • Association for Academic Surgery-Member
  • Pancreas Club-Member

Videos & Media

Liver Cancer | Q&A

Liver Cancer | Thelma's Story

What’s New: Surgical Treatment of Pancreatic Cancer and Disease

Johns Hopkins Surgical Oncologists Get Personal

Learn more about Johns Hopkins cancer surgery at The surgical oncology team at Johns Hopkins gets personal as they speak about their role in treating their patients and what the Promise of Medicine means to them.

Tomorrow's Discoveries: Using Robotic Surgery to Treat Pancreatic Cancer

Recent News Articles and Media Coverage

4 Liver Cancer Treatment Advances

Liver Cancer: 3 Things You Should Know

Liver Cancer: Multidisciplinary Care Matters

Liver Cancer: What You Need to Know, Johns Hopkins Surgery (4/13/2017)

The Ins and Outs of Minimally Invasive Whipple, Johns Hopkins Surgery (5/10/2016)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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