Research Summary
My research interest focuses on the natural history of frailty and its phenotypic components including sarcopenia and low physical activity. As a co-investigator of the Women’s Health and Aging Studies since 2001, I’ve been spearheading the analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty. This work is providing a critical foundation for the next generation of research to delineate the synergistic effects of dysregulation in multiple biological systems on frailty. It promises to provide new biological insights and, thereby, inform the development of new interventions to treat the concurrent multisystem changes that occur in accelerated aging. In addition, I have recently developed an interest in methods to study the clinical relevance of aging-related loss of muscle mass and strength in older adults (referred to as sarcopenia), with the goal of establishing the prognostic value of intra-person variability and change in muscle mass and strength for long-term health outcomes.
Technology Expertise Keywords
Biostatistics
Clinical Trials
Baltimore Experience Corps Trial
The Community Aging in Place, Advancing Better Living for Elders Trial
Selected Publications
View all on PubMed
Xue QL, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008; 63(9): 984–990. PMID: 18840805
Xue QL, Buta B, Ma LN, Ge ML, Carlson MC. Integrating Frailty and Cognitive Phenotypes: Why, How, Now What? Current Geriatrics Reports. April 2019
Chu NM, Bandeen-Roche K, Tian J, Kasper JD, Gross AL, Carlson M, Xue QL. Hierarchical Development of Frailty and Cognitive Impairment: Clues into Etiological Pathways. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1761-1770. doi: 10.1093/gerona/glz134. PMID: 31120105
Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):387-393. doi: 10.1093/gerona/glz052. PMID: 30789645
Xue QL. Frailty as an integrative marker of physiological vulnerability in the era of COVID-19. BMC Med. 2020 Oct 23;18(1):333. doi: 10.1186/s12916-020-01809-1. PMID: 33092582
Patient Ratings & Comments
The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.