Dr. Kadam's doctoral research involved the study of epileptogenesis using in vivo ECOG monitoring using telemetry and in vitro slice electrophysiology in a rat model of perinatal hypoxia-ischemia. During her fellowship training at Hopkins she investigated the effect of neonatal strokes on endogenous neurogenesis in the neurogenic niches of the sub-granular and sub-ventricular zones in the central nervous system.
Using the expertise gained during her pre-doctoral training in the Dudek Lab, she has established a mouse electroencephalogram (EEG) laboratory at the Kennedy Krieger Institute with capabilities of recording chronic and continuous EEGs. Dr. Kadam is interested in investigating epileptogenesis in animal models of developmental disabilities with the goal to test novel therapies. Her current research projects involve characterizing the acute electrographic seizures and investigating the evolution of refractoriness following ischemia in the neonatal period. She is also invested in multiple collaborations investigating epileptogenesis in models of developmental disabilities both genetic and acquired.
Lab Website: Kadam Lab
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Kang SK, Johnston MV, Kadam SD (2015). Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. Eur J Neurosci. 42(10), 2792-804
Ammanuel S, Chan WC, Adler DA, Lakshamanan BM, Gupta SS, Ewen JB, Johnston MV, Marcus CL, Naidu S, Kadam SD (2015). Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency. PLoS One. 10(10), e0138113
Kang SK, Markowitz GJ, Kim ST, Johnston MV, Kadam SD (2015). Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Front Cell Neurosci. 9, 173
Adler DA, Ammanuel S, Lei J, Dada T, Borbiev T, Johnston MV, Kadam SD, Burd I (2014). Circadian cycle-dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation. Neuroscience. 275, 305-13. Abstract
Johnston MV, Ammanuel S, O'Driscoll C, Wozniak A, Naidu S, Kadam SD (2014). Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice. Front Syst Neurosci. 8, 118. Abstract
Compositions and Methods for Treating Refractory Seizures
Patent # C13033
U.S. Patent Application entitled “Compositions and Methods for Treating Refractory Seizures,” Serial No. 62/037,654 (filed August 8, 2015)
Invention C13033 was reported to NIH through the iEdison system on 3/23/15.