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Gabriel Ghiaur, M.D., Ph.D.

Photo of Dr. Gabriel Ghiaur, M.D., Ph.D.
  • Assistant Professor of Oncology
Male

Languages: English, Romanian

Expertise

Bone Marrow Transplant, Hematology, Immunotherapy, Leukemia

Research Interests

Leukemia; Bone Marrow Transplant; Hematopoietic Stem Cell Biology and Leukemia Stem Cells; Bone Marrow Microenvironment; Natural Killer Cells ...read more

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Insurance Information

Maryland

443-287-6997

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 443-287-6997
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-3183

Background

Dr. Ghiaur, a member of the Johns Hopkins Kimmel Cancer Center, is a physician-scientist whose primary interest is normal and malignant hematopoiesis, especially the role of the microenvironment in cell extrinsic drug resistance and persistence of minimal residual disease. He has distinguished himself as an outstanding laboratory-based investigator and a superior clinician. His research has translational potential in stem cell therapeutics, as well as acute leukemia and multiple myeloma.

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Titles

  • Assistant Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Medicine, Carol Davila University of Medicine (2001)

Residencies

  • The Christ Hospital / Internal Medicine (2009)

Fellowships

  • Johns Hopkins University School of Medicine / Hematology (2013)

Board Certifications

  • American Board of Internal Medicine / Hematology (2011)

Research & Publications

Lab Website: Ghiaur

Clinical Trial Keywords

Leukemia, Bone Marrow Transplant, Hematologic Malignancies, Natural Killer Cells

Selected Publications

View all on Pubmed

Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa J, Gerber J, and Jones RJ. Regulation of Hematopoietic Stem Cell Self-Renewal by the Microenvironment’s Control of Retinoic Acid Signaling. PNAS, 2013, Oct1; 110(40):16121-6. Epub 2013 Sep 16. PMID: 24043786. PMCID: PMC3791732

Alonso S, Hernandez D, Chang YT, Gocke CD, McCray M, Varadhan R, Matsui WH, Jones RJ, Ghiaur G. Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance. J Clin Invest. 2016 Dec 1;126(12):4460-4468. doi: 10.1172/JCI88152 PMID: 27775549

Ghiaur G, Levis M. Mechanisms of Resistance to FLT3 Inhibitors and the Role of the Bone Marrow Microenvironment. Hematol Oncol Clin North Am. 2017 Aug;31(4):681-692. doi: 10.1016/j.hoc.2017.04.005. Epub 2017 May 18. Review. PubMed PMID: 28673395; PubMed Central PMCID: PMC5512588.

Su M, Chang YT, Hernandez D, Jones RJ, Ghiaur G. Regulation of drug metabolizing enzymes in the leukaemic bone marrow microenvironment. J Cell Mol Med. 2019 Jun;23(6):4111-4117. doi: 10.1111/jcmm.14298. Epub 2019 Mar 28. PubMed PMID: 30920135; PubMed Central PMCID: PMC6533513

Hernandez D, Palau L, Norsworthy K, Anders NM, Alonso S, Su M, Petkovich M, Chandraratna R, Rudek MA, Smith BD, Jones RJ, Ghiaur G. Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids. Leukemia. 2020 Mar 9;. doi: 10.1038/s41375-020-0790-4. [Epub ahead of print] PubMed PMID: 32152463.

Activities & Honors

Honors

  • Fellow, American Society of Hematology, 2012 - 2013
  • Fellow, Maryland Stem Cell Research, 2012 - 2014
  • Passano Physician Scientist Award, 2014
  • American Society of Clinical Investigator (ASCI) Young Physician-Scientist Award, 2017
  • Blood Mentor, ASH-a-Palooza, American Society of Hematology Annual Meeting, 2019
  • Visiting Professor in Hematopoiesis, Cluj School of Medicine, 2018 - 2019

Memberships

  • American Association of Cancer Research
  • American Society of Hematology
  • Romanian Society of Hematology
  • Romanian Society of Bone Marrow Transplantation, Honorary Member

Professional Activities

  • Leukemia attending physician
  • Director, Normal and Oncologic Tissue Collection Hub (NOTCH) biorepository
  • Associate Chair, Education Committee, Sidney Kimmel Comprehensive Cancer Center
  • Director, Visiting Professor Series and Translational Research Conference

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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