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Research Interests: Signaling Mechanisms; Bioactive Food Components; Novel Therapeutics; Tamoxifen Resistance; Metastasis; Adipocytokines; Obesity-Cancer Connection; Breast Cancer
The research in Sharma lab is focused in two main areas:
Sharma, D., and Fondell, J. D. Ordered recruitment of histone aceyltransferases and TRAP/Mediator complex to thyroid hormone responsive promoters in vivo. Proc. Natl. Acad. Sci., USA, 99(12): 7934-7939, 2002.
Sharma, D., Saxena, N. K., Davidson, N. E., and Vertino, P. M. Restoration of tamoxifen sensitivity in ER-negative breast cancer cells. Tamoxifen-bound reactivated estrogen receptor recruits distinct chromatin modifying corepressors complexes. Cancer Research, 66: 6370-6378, 2006.
Sharma, D., Blum, J., Yang, X., Beaulieu, N., Macleod, A. R., and Davidson, N. E. Release of Methyl CpG Binding Proteins and Histone Deacetylase 1 from the Estrogen Receptor Alpha (ER) Promoter upon Reactivation in ER-negative Human Breast Cancer Cells. Mol Endocrinol., 19 (7): 1740-1751, 2005.
Sharma, D., Wang, J., Fu, P. P., Sharma, S., Nagalingam, A., Mells, J., Handy, J., Page, A. J., Cohen, C., Anania, F. A., and Saxena, N. K. Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis. Hepatology, 52(5): 1713-1722, 2010.
Nagalingam, A., Kuppusamy, P., Singh, S. V., Sharma, D* and Saxena, N. K. Mechanistic elucidation of the antitumor properties of Withaferin A in breast cancer. Cancer Research, 74(9):2617-29, 2014.
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