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School of Medicine
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Guang William Wong, Ph.D.
Professor of Physiology
Research Interests: Mechanisms of insulin resistance and type 2 diabetes; Function of adipose-and skeletal muscle-derived hormones; Mechanisms governing metabolic homeostasis ...read more
Dr. Guang Wong is an assistant professor of physiology at the Johns Hopkins University School of Medicine. His research focuses on mechanisms governing metabolic homeostasis, function of adipose-and skeletal muscle-derived hormones, and mechanisms of insulin resistance and type 2 diabetes.
He received in B.S. from Washington State University and his Ph.D. from Harvard University in 2000. Dr. Wong completed post-doctoral work in biochemistry, cell biology, and physiology at M.I.T’s Whitehead Institute from 2001 - 2007. He joined the Johns Hopkins faculty in 2008.
Dr. Wong’s lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis and is currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in his lab, regulate tissue crosstalk and signaling pathways to control energy metabolism.
- Professor of Physiology
Departments / Divisions
- B.S., Washington State University (Washington) (1994)
- Ph.D., Harvard University (Massachusetts) (2000)
Whitehead Institute, M.I.T., Cambridge, MA, 2007, Biochemistry, Cell Biology, and Physiology
Research & Publications
Dr. Wong’s laboratory is interested in understanding how various organs in the body coordinate the complex metabolic networks and circuitry to maintain proper energy balance. Specifically, his lab focuses on characterizing a novel family of endocrine mediators secreted by adipose tissue.
Current projects seek to understand how these circulating factors regulate fat mass as well as systemic insulin sensitivity, glucose and lipid metabolism. These secreted factors, all belong to the C1q/TNF protein family, are related in structure and function to the insulin-sensitizing hormone, adiponectin. A variety of in vitro and in vivo (transgenic and knockout mice) approaches are being employed in his lab to dissect the function and mechanisms of action of these molecules.
Wei Z, Lei X, Pedersen PS, Aja S, and Wong GW. "Targeted deletion of CTRP9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice." Am J Physiol Endocrinol Metab. 306:E779-E790, 2014.
Peterson JM, Seldin M,Tan SY, and Wong GW. "CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice." PLoS One 9(2):e88535 (2014)
Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, and Wong GW. "CTRP4 is a unique secreted protein with two tandem C1q domain that functions in the hypothalamus to modulate food intake and body weight." J Biol Chem.289, 2014.
Seldin MM, Lei X, Tan S, Stanson KP, Wei Z, and Wong GW. "Skeletal muscle-derived myonectin activates the mTOR pathway to suppress autophagy in liver." J Biol Chem. 288:36073-82, 2013.
Byerly MS, Swanson R, Wong GW, and Blackshaw S. "Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression." PLoS One 8(11):e80781, 2013.
Activities & Honors
- Travel fellowship, Human Genome Organization (HUGO), 2004
- Scientist Development Grant, American Heart Association, 2009
- National Research Service Award (postdoctoral fellowship), NIH, 2004 - 2007
- Pharmacia Allergy Research Award (Sweden), 2000
- Howard Hughes Undergraduate Investigator Award, 1992