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Guang William Wong, Ph.D.

Photo of Dr. Guang William Wong, Ph.D.
  • Professor of Physiology

Research Interests

Mechanisms of insulin resistance and type 2 diabetes; Function of adipose-and skeletal muscle-derived hormones; Mechanisms governing metabolic homeostasis ...read more

Background

Dr. G. William Wong is a Professor of Physiology at the Johns Hopkins University School of Medicine. His research focuses on mechanisms governing metabolic homeostasis, function of adipose-and skeletal muscle-derived hormones, and mechanisms of insulin resistance and type 2 diabetes. 

He received in B.S. from Washington State University and his Ph.D. from Harvard University in 2000. Dr. Wong completed post-doctoral work in biochemistry, cell biology, and physiology at M.I.T’s Whitehead Institute from 2001 - 2007. He joined the Johns Hopkins faculty in 2008.

Dr. Wong’s lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis and is currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in his lab, regulate tissue crosstalk and signaling pathways to control energy metabolism.

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Titles

  • Professor of Physiology
  • Joint Appointment in Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., Harvard University (Massachusetts) (2000)
  • B.S., Washington State University (Washington) (1994)

Additional Training

Whitehead Institute, M.I.T., Cambridge, MA, 2007, Biochemistry, Cell Biology, and Physiology

Research & Publications

Research Summary

Dr. Wong’s laboratory is interested in understanding how various organs in the body coordinate the complex metabolic networks and circuitry to maintain proper energy balance. Specifically, his lab focuses on characterizing a novel family of endocrine mediators secreted by adipose tissue.

Current projects seek to understand how these circulating factors regulate fat mass as well as systemic insulin sensitivity, glucose and lipid metabolism. These secreted factors, all belong to the C1q/TNF protein family, are related in structure and function to the insulin-sensitizing hormone, adiponectin. A variety of in vitro and in vivo (transgenic and knockout mice) approaches are being employed in his lab to dissect the function and mechanisms of action of these molecules.

Contact for Research Inquiries

855 N. Wolfe Street
Rangos 474
Baltimore, MD 21205 map

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Activities & Honors

Honors

  • Travel fellowship, Human Genome Organization (HUGO), 2004
  • Scientist Development Grant, American Heart Association, 2009
  • National Research Service Award (postdoctoral fellowship), NIH, 2004 - 2007
  • Pharmacia Allergy Research Award (Sweden), 2000
  • Howard Hughes Undergraduate Investigator Award, 1992
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