Dr. Wong’s laboratory is interested in understanding how various organs in the body coordinate the complex metabolic networks and circuitry to maintain proper energy balance. Specifically, his lab focuses on characterizing a novel family of endocrine mediators secreted by adipose tissue.
Current projects seek to understand how these circulating factors regulate fat mass as well as systemic insulin sensitivity, glucose and lipid metabolism. These secreted factors, all belong to the C1q/TNF protein family, are related in structure and function to the insulin-sensitizing hormone, adiponectin. A variety of in vitro and in vivo (transgenic and knockout mice) approaches are being employed in his lab to dissect the function and mechanisms of action of these molecules.
Wei Z, Lei X, Pedersen PS, Aja S, and Wong GW. "Targeted deletion of CTRP9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice." Am J Physiol Endocrinol Metab. 306:E779-E790, 2014.
Peterson JM, Seldin M,Tan SY, and Wong GW. "CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice." PLoS One 9(2):e88535 (2014)
Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, and Wong GW. "CTRP4 is a unique secreted protein with two tandem C1q domain that functions in the hypothalamus to modulate food intake and body weight." J Biol Chem.289, 2014.
Seldin MM, Lei X, Tan S, Stanson KP, Wei Z, and Wong GW. "Skeletal muscle-derived myonectin activates the mTOR pathway to suppress autophagy in liver." J Biol Chem. 288:36073-82, 2013.
Byerly MS, Swanson R, Wong GW, and Blackshaw S. "Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression." PLoS One 8(11):e80781, 2013.