The Functional Neurosurgery Lab uses computer modeling of epilepsy to try to understand how seizures develop in the brain, and how and where they spread. The models can be used to understand how medication or electrical stimulation can affect seizures. The lab also works on the development of novel neuromodulation systems including closed-loop stimulation techniques.
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Anderson WS, Kudela P, Cho RJ, Bergey GK, Franaszczuk P. Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 2007;97:173-194
Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic seizures from abnormal networks: Why some seizures defy predictability. Epi Res 2012;99(3):202-213
Anderson WS, Kudela P, Weinberg S, Bergey GK, Franaszczuk PJ. Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation. Epi Res 2009;84:42-55
Azhar F, Anderson WS. Prediction of single neuron spikes in sensorimotor cortex may reflect generic properties of locally connected networks. Neural Comp: 2012;24(10):2655-2677
Kudela P, Anderson WS. Computational modeling of subdural cortical stimulation: A quantitative spatiotemporal analysis of action potential initiation in a high density multicompartment model. Neuromod: Tech Neural Interface: 2015;doi: 10.1111/ner.12327