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William Stanley Anderson, M.A., M.D., Ph.D.
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Expertise: Deep Brain Stimulation, Dystonia, Epilepsy Surgery, Essential Tremor, Intrathecal Baclofen Therapy, Neurosurgery, Parkinson's Disease, Spinal Cord Stimulation Therapy, Temporal Lobectomy, Therapeutic Neuromodulation ...read more
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1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287
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6420 Rockledge Drive
Suite 4920
Bethesda, MD 20817
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Phone: 301-896-6069
601 N. Caroline St.
Baltimore, MD 21287
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The Anderson Laboratory focuses on the computational modeling of epilepsy as a method to understand the time and spatial evolutionary properties of seizures. Modeling methods include large array single compartment models and multicompartment simulations for the extraction of electrophysiological observables. Using these modeling tools, we explore how fast seizures spread, the spatial extent of spread, the spread of interictal spikes, and the introduction of therapies such as drug diffusion and electrical stimulation. The laboratory also explores the effects on memory encoding of theta phase specific stimulation during working memory tasks. Recordings derived from deep brain stimulation procedures are also used to learn more about motor imagery and motor planning.
Anderson WS, Kudela P, Cho RJ, Bergey GK, Franaszczuk P. Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 2007;97:173-194
Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic seizures from abnormal networks: Why some seizures defy predictability. Epi Res 2012;99(3):202-213
Anderson WS, Kudela P, Weinberg S, Bergey GK, Franaszczuk PJ. Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation. Epi Res 2009;84:42-55
Azhar F, Anderson WS. Prediction of single neuron spikes in sensorimotor cortex may reflect generic properties of locally connected networks. Neural Comp: 2012;24(10):2655-2677
Kudela P, Anderson WS. Computational modeling of subdural cortical stimulation: A quantitative spatiotemporal analysis of action potential initiation in a high density multicompartment model. Neuromod: Tech Neural Interface: 2015;doi: 10.1111/ner.12327
Epilepsy Surgery: Jeannie's Story
After a viral brain infection left South Carolina native Jeannie with epileptic seizures that couldnt be controlled by medication, physicians from the Johns Hopkins Epilepsy Center removed the part of her brain where the seizures originated. Fifteen months later, Jeannie continues to be seizure-free and is back to enjoying life. Visit http://www.hopkinsmedicine.org/neuro.
An Electrifying New Way to Fight Epilepsy, NeuroLogic (Spring 2015)
A Stimulating Approach to Alzheimer’s, Doorways to Discovery (November 2014)
New Approaches to Taming Seizures, Collaborations in Discovery (November 2011)
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