Research Summary
The long-term research goal of the Wang laboratory is to understand the molecular mechanisms that regulate cardiovascular and hematopoietic differentiation of pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced-pluripotent stem (iPS) cells. Pluripotent stem cells hold great potential for regenerative medicine, and gene therapy. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation.
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Selected Publications
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Shen J, Xu Y, Zhang S, Lyu S, Huo Y, Zhu Y, Tang K, Mou J, Li X, Hoyle DL, Wang M, Wang J, Li X, Wang ZZ, Cheng T. Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs. Sci Adv. 2021 Sep 3;7(36):eabi9787. doi: 10.1126/sciadv.abi9787. Epub 2021 Sep 3. PubMed PMID: 34516916; PubMed Central PMCID: PMC8442917
Kruse RL, Huang Y, Lee A, Zhu X, Shrestha R, Laeyendecker O, Littlefield K, Pekosz A, Bloch EM, Tobian AAR, Wang ZZ. A Hemagglutination-Based Semiquantitative Test for Point-of-Care Determination of SARS-CoV-2 Antibody Levels. J Clin Microbiol. 2021 Nov 18;59(12):e0118621. doi: 10.1128/JCM.01186-21. Epub 2021 Sep 1. PubMed PMID: 34469185; PubMed Central PMCID: PMC8601214
Shen J, Zhu Y, Lyu C, Feng Z, Lyu S, Zhao Y, Hoyle DL, Ji G, Miao W, Zhang X, Cheng L, Brodsky RA, Cheng T, Wang ZZ. Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells. Haematologica. 2020;105(2):e48-e51. doi: 10.3324/haematol.2018.211664. Print 2020. PubMed PMID: 31197070; PubMed Central PMCID: PMC7012464.
Shen J, Lyu C, Zhu Y, Feng Z, Zhang S, Hoyle DL, Ji G, Brodsky RA, Cheng T, Wang ZZ. Defining early hematopoietic-fated primitive streak specification of human pluripotent stem cells by the orchestrated balance of Wnt, activin, and BMP signaling. J Cell Physiol. 2019 Feb 10;. doi: 10.1002/jcp.28272. [Epub ahead of print] PubMed PMID: 30740687; PubMed Central PMCID: PMC6689260
Bai H, Gao Y, Hoyle DL, Cheng T, Wang ZZ. Suppression of Transforming Growth Factor-β Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells. Stem Cells Transl Med. 2017 Feb;6(2):589-600. doi: 10.5966/sctm.2016-0089. Epub 2016 Sep 20. PubMed PMID: 28191769; PubMed Central PMCID: PMC5442820
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