- Co-Director, Stem Cell Biology Laboratory
- Associate Professor of Oncology
Departments / Divisions
- Oncology - Cancer Genetics and Epigenetics
The Jang lab focuses on understanding stem cell fate changes and their therapeutic applications. Her team uses both multipotent and pluripotent stem cells as research tools for studying pathogenesis of liver diseases, including chronic liver diseases and carcinogenesis. Researchers in the Jang lab generated a large panel of human induced pluripotent stem cell (iPSC) lines - both from healthy and diseased tissues - including primary hepatocytes, bone marrow stem cells, blood cells, keratinocytes, fibroblasts and tumor cells. In addition, they successfully differentiated these iPSCs into early and late stage hepatic cells by a step-wise hepatic specification protocol. Jang's research team showed the comprehensive functionality of these iPSC-derived liver cells using both in vitro and in vivo assays. Recently, their iPSC generation and hepatic differentiation technologies were successfully used in liver disease modeling, drug testing and cell therapy. Jang's lab is currently committed to the discovery and development of novel therapeutic approaches to liver disease prevention and treatment using this patient-specific iPSC technology.