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Kristin Bigos, Ph.D.

Photo of Dr. Kristin Bigos, Ph.D.

Assistant Professor of Medicine

Background

Dr. Kristin Bigos is an Assistant Professor of Medicine and of Psychiatry at the Johns Hopkins University School of Medicine. Her research focuses on neuropsychiatric drug development and a precision medicine approach to the treatment of mental illness.

The Bigos Lab uses functional MRI as a biomarker to test the neural effects of drugs designed to treat cognitive dysfunction in schizophrenia. Other studies aim to identify patient-specific variables including sex, race, and genetics that impact drug clearance and clinical response to better select and dose antipsychotics and antidepressants. 

Dr. Bigos received her B.S. in Premedicine from the Pennsylvania State University. She earned her Ph.D. in Clinical Pharmaceutical Sciences from the University of Pittsburgh. She completed a post-doctoral fellowship in the Clinical Brain Disorders Branch of the Intramural Research Program of the National Institute of Mental Health under Dr. Daniel Weinberger.

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Titles

  • Assistant Professor of Medicine
  • Assistant Professor of Psychiatry and Behavioral Sciences

Education

Degrees

  • B.S., Pennsylvania State University (Pennsylvania) (2001)
  • Ph.D., University of Pittsburgh (Pennsylvania) (2007)

Additional Training

National Institute of Mental Health, Bethesda, MD, 2011, Clinical Brain Disorders Branch

Research & Publications

Research Summary

The Bigos Lab focuses on a Precision Medicine approach to the treatment of psychiatric illness. In addition, this lab employs functional neuroimaging and genetics as biomarkers in neuropsychiatric drug development. A recent study used functional MRI to test the neural effects of a drug with the potential to treat cognitive dysfunction in schizophrenia. Other studies aim to identify patient-specific variables including sex, race, and genetics that impact drug clearance and clinical response to better select and dose antipsychotics and antidepressants. 

Technology Expertise Keywords

brain disorders; neuroimaging; pharmacogenetics; schizophrenia

Clinical Trials

Functional Neuroimaging of Nimodipine in Healthy Adults

Selected Publications

View all on Pubmed

Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B, Hyde TM, Lipska BK, Kleinman JE, Weinberger DR. Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness. Arch Gen Psychiatry 2010; 67(9):939-45

Heide J, Zhang F, Bigos KL, Mann SA, Carr VJ, Shannon-Weickert C, Green MJ, Weinberger DR, Vandenberg JI. Differential response to antipsychotics in schizophrenia patients with KCNH2 risk alleles is correlated with affinities for the Kv11.1-3.1 potassium channel. Am J Psychiatry. 2016;173(1):53-59

Bigos KL, Bies RR, Pollock BG, Lowy JJ, Zhang F, Weinberger DR. Genetic Variation in CYP3A43 Explains Racial Difference in Olanzapine Clearance. Molecular Psychiatry. 2011; 16:620-625

Dickinson D, Straub RE, Trampush J, Gao Y, Feng N Xie B, Shin JH, Lim HK Callicott JH, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Rujescu D, Hyde TM, Berman KF, Kleinman JE, Weinberger DR. Interaction of common variants in SCN2A with schizophrenia and general cognitive ability, brain physiology and mRNA expression in brain. JAMA Psychiatry. 2014;71(6):647-56

Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies RR, Hariri AR. Acute 5-HT Reuptake Blockade Potentiates Human Amygdala Reactivity. Neuropsychopharmacology 2008; 33:3221-3225

Contact for Research Inquiries

600 N. Wolfe Street
Osler 503
Baltimore, MD 21287 map
Phone: 410-614-0453

Activities & Honors

Honors

  • Fellows Award for Research Excellence, National Institutes of Health, 2010 - 2010
  • Pharmaceutical Sciences Graduate Student Excellence Award, University of Pittsburgh School of Pharmacy, 2005
  • Ruth L. Kirschstein National Research Service Award, National Institutes of Health, 2005 - 2007
  • Fellowship, American Foundation for Pharmaceutical Education, 2004 - 2005
  • W. Leigh Thompson, MD Excellence in Research Award: Clinical Research Junior Faculty, JHU Department of Medicine, 2016 - 2016
  • Emerging Women’s Leadership Program, JHU School of Medicine, 2016 - 2016
  • New Clinical Drug Evaluation Unit (NCDEU) New Investigator Award, 2013 - 2013
  • American College of Neuropsychopharmacology Young Investigator Travel Award, 2011 - 2011
  • Pharmacogenetics in Psychiatry Meeting Young Investigator Travel Award, 2011 - 2011
  • Top Poster Award, Society of Biological Psychiatry, 2010 - 2010
  • Travel Fellowship, Winter Conference on Brain Research, 2010 - 2010

Memberships

  • American College of Neuropsychopharmacology
  • Society of Biological Psychiatry
  • American Society of Clinical Pharmacology and Therapeutics

    Chair, Mental Health and Addiction Community

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