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Daniela Cihakova, M.D., Ph.D.

Photo of Dr. Daniela Cihakova, M.D., Ph.D.
  • Associate Director, Clinical Immunology Laboratory, Department of Pathology
  • Associate Professor of Pathology

Research Interests

Cardiac Immunology; Macrophages; Fibroblasts; Innate Immune Cells; T-cells; PD-1; PDL-1; Cytokines; Congenital Heart Block; Sjogren's Syndrome; Myocarditis; Autoimmunity; Immunology, Schizophrenia ...read more

Background

Dr. Daniela Cihakova is an Associate Professor of Pathology at the Johns Hopkins University School of Medicine. She also has a joint appointment in the Department of Molecular Microbiology and Immunology. Dr. Cihakova is an American Board of Medical Laboratory Immunology (ABMLI) certified clinical laboratory immunologist and an Associate Director of Immunology Clinical Laboratory at Johns Hopkins University.  

Her research focuses on the cardiac immunology and understanding how immune cells and cardiac stromal cells contribute to the pathogenesis of various cardiovascular diseases such as myocarditis, dilated cardiomyopathy, pericarditis, myocardial infarction or check point inhibitors induced cardiac inflammation.

Dr. Cihakova earned her M.D. and Ph.D. from Charles University in Prague, Czech Republic. She completed her postdoctoral fellowship at Johns Hopkins University in 2006. Dr. Cihakova joined the Johns Hopkins faculty in 2008.

Dr. Cihakova research has been supported by the NIH/NHBLI, American Heart Association,  Children's Cardiomyopathy Foundation, W.W. Smith Charitable Trust, Mirowski Discovery Award, National Organization for Rare Diseases, and American Autoimmune Related Disease Association (AARDA), Sjogrens syndrome Foundation, Matthew Poyner MVP Memorial Myocarditis Research Foundation, Myocarditis Foundation.

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Titles

  • Associate Director, Clinical Immunology Laboratory, Department of Pathology
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • Ph.D., Charles University (Czech Republic) (2003)
  • M.D., Charles University (Czech Republic) (1998)

Additional Training

  • The American Board of Medical Laboratory Immunology, The American College of Microbiology, Medical Laboratory Immunology (2013)

Research & Publications

Research Summary

Dr. Cihakova’s research interest is cardiac Immunology. She focuses on examining the role of various immune cells such as macrophaes, T cells, Innate lymphoid cells and their mediators cytokines and chemokines in pathogenesis of cardiac diseases such as myocarditis, dilated cardiomyopathy, myocardial infarction and  pericarditis.  Dr. Cihakova is also interested in the pathogenic role of SSA/SSB antibodies in development of congenital complete heart block.

Lab

Dr. Cihakova’s lab focuses on two main areas related to myocarditis. The first area of interest is the role of the inflammatory cytokines in myocarditis and DCMI. They have discovered that IL17A is critical for progression from myocarditis to DCMI while not being essential for myocarditis development (Baldeviano et al, 2010). They are currently investigating the mechanism of how IL-17A is driving DCMI and have evidence that IL17A and cardiac resident cells interaction is critical for DCMI. Dr. Cihakova and her lab are also interested in the role of the various inflammatory cells in myocarditis and how they contribute to the cardiac remodeling and DCMI. Clinically, different types of myocarditis are recognized based on the predominant infiltrating cell type such as giant cell myocarditis or eosinophilic necrotizing myocarditis. They have developed several models that reflect closely these clinical myocarditis entities. These models allow them to investigate the role of neutrophils, T cells, NK cells, myeloid cells and eosinophils and their contribution to cardiac inflammation and remodeling.

Lab Website: Cihakova Research Laboratory
Core Facility: Immunology

Technology Expertise Keywords

Multiparameter Flow Cytometry, Cardiac Mice Models, ELISA, Indirect Fluorescence

Selected Publications

Chen G, Bracamonte-Baran W, Diny NL, Hou X, Talor MV, Fu K, Liu K, Davogustto G, Vasquez H, Taegtmeyer H, Frazier OH, Waisman A, Conway SJ, WanF, Cihakova D*. Cardiac Fibroblasts Promote Development of Heart Failure, European Journal of Immunology. 2018.48(9):1522-1538. Article was chosen as a front cover story.

Bracamonte-Baran W, Chen G, Hou X, Talor MV, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam DJ, Nauen D and Cihakova D*. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Front. Immunol., 29 March 2019

Diny NL, Baldeviano GC, Talor MV, Barin JG, Ong S, Bedja D, Hays GH, Gilotra NA, Coppens I, Rose NR, and Cihakova D*. Eosinophil-derived IL4 drives progression of myocarditis to inflammatory dilated cardiomyopathy. Journal of Experimental Medicine, 2017; 214(4):943-957. Article was chosen as a front cover story.

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura5 Y, Rose NR, and Cihakova D*. Cardiac Fibroblasts Mediate IL-17A-Driven Inflammatory Dilated Cardiomyopathy. Journal of Experimental Medicine. 2014; 211(7):1449-64 (article was featured by website Faculty 1000)

Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D*. Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy. Circ Res. 2010; 106(10):1646-1655. (Editorial choice – featured as "In this Issue")

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Pathobiology, Johns Hopkins University

Immunology Training Program, School of Medicine, Johns Hopkins University

Graduate Program, Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University

Courses and Syllabi

  • Clinical Immunology (260.712.01)

Activities & Honors

Professional Activities

  • Editorial Board, Clinical Immunology, 2011
  • ad hoc - multiple study sections, NIh/NHLBI, 2012
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