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Monica Smith Pearl, M.D.

Photo of Dr. Monica Smith Pearl, M.D.
  • Associate Professor of Radiology and Radiological Science


Acute Stroke Care, Aneurysmal Subarachnoid Hemorrhage (ASH), Arteriovenous Fistulas (AVF), Arteriovenous Malformations (AVM), Atherosclerosis, Carotid Artery Stenosis, Cerebral Aneurysms, Cerebral Vascular Malformations, Cerebrovascular Diseases, Diagnostic Radiology, Endovascular Treatment Options for Pediatric Tumors of the Head and Neck, Endovascular Treatment Options for Pediatric Tumors of the Spine, Intracerebral Hemorrhage , Intracranial Aneurysm, Moyamoya Disease, Neuroradiology, Neurovascular interventions, Pediatric Neurovascular Disorders, Sclerotherapy, Spinal Vascular Malformations, Stroke, Stroke Imaging, Stroke Prevention, Stroke Recovery, Stroke Rehabilitation, Transient Ischemic Attack, Vascular Malformations of the Head, Vascular Malformations of the Neck more

Research Interests

Radiation dose reduction; Intra-arterial chemotherapy for retinoblastoma; Intra-arterial chemotherapy for diffuse intrinsic pontine gliomas; Multimodality fusion, image guidance; Pediatric cerebrovascular diseases more


The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-8525
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Suite 7218
Baltimore, MD 21287 map
Fax: 410-614-8238

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-955-8525
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-8525 | Fax: 410-614-8238


Dr. Monica Smith Pearl is an Associate Professor in the Johns Hopkins University School of Medicine Department of Radiology and Radiological Science, Division of Interventional Neuroradiology. She is the Program Director for the Endovascular Surgical Neuroradiology Fellowship and the Director of Faculty Experience for the Department of Radiology.

Her areas of specialization within interventional neuroradiology include adult and pediatric neurovascular disorders. She performs diagnostic and therapeutic cerebral angiography procedures for the following conditions: superficial vascular anomalies of the face, orbit, and scalp including facial arteriovenous malformations (AVMs), lymphatic malformations, and venous malformations. Dr. Pearl also specializes in intracranial arteriovenous malformations (AVMs), dural arteriovenous fistulas (DAVFs), pulsatile tinnitus, temporal bone imaging, stroke interventions, cerebral aneurysms, intracerebral hemorrhage, and sclerotherapy.

Dr. Pearl received her B.S. in mathematics from the University of North Carolina at Chapel Hill in 1998 and her M.D. from Duke University in 2002. Following training in general surgery and diagnostic radiology at the George Washington University, she earned her certification from the American Board of Radiology in 2008. After completing fellowships in both diagnostic neuroradiology and interventional neuroradiology at the Johns Hopkins University, she joined the Johns Hopkins faculty in 2010.

In addition to being an Editor-in-Chief for the Journal of Pediatric Neuroradiology, she is also a member of the American Society of Neuroradiology, American College of Radiology, Senior Member of the Society of Neurointerventional Surgery and a Diplomate of the American Board of Radiology with subspecialty board certification in neuroradiology. more


  • Associate Professor of Radiology and Radiological Science

Departments / Divisions



  • M.D., Duke University School of Medicine (Durham) (North Carolina) (2002)
  • B.A., University of North Carolina (Chapel Hill) (North Carolina) (1998)

Research & Publications

Research Summary

Dr. Pearl’s research interests include the diagnosis and treatment of adult and pediatric neurovascular diseases, superficial vascular malformations including arteriovenous malformations (AVMs), venous malformations, and lymphatic malformations. She also focuses on radiation dose reduction strategies and innovative endovascular therapies for adult and pediatric tumors of the head, neck and spine. She is the principal investigator for an active phase II clinical trial involving the intra-arterial administration of chemotherapy for intraocular retinoblastoma. She is also the principal investigator for a phase I clinical trial involving the intra-arterial administration of chemotherapy for progressive diffuse intrinsic pontine gliomas. 

Clinical Trial Keywords

Diffuse intrinsic pontine glioma, Retinoblastoma, Pontine glioma, Intra-arterial chemotherapy

Clinical Trials

Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma

Intra-arterial Chemotherapy for the Treatment of Progressive Diffuse Intrinsic Pontine Gliomas

Selected Publications

View all on Pubmed

Pearl MS, Wolinsky JP, Gailloud P. Preoperative embolization of primary spinal aneurysmal bone cysts by direct percutaneous intralesional injection of n-BCA. J Vasc Interv Radiol. 2012 Jun;23(6):841-5

Pearl MS, Chen JX, Gregg L, San Millan D, Belzberg A, Jallo G, Gailloud P. Angiographic detection and characterization of cryptic venous anomalies associated with spinal cord cavernous malformations using flat panel catheter angiotomography (FPCA). Neurosurgery. 2012 May 16. [Epub ahead of print]

Pearl M, Gregg L, Gailloud P. Endovascular treatment of aneurysmal subarachnoid hemorrhage. Neurosurg Clin N Am. 2010 Apr; 21 (2): 271-280

Puttgen K, Pearl M, Tekes A, Mitchell S. Update on pediatric extracranial vascular anomalies of the head and neck. Childs Nerv Syst. 2010 Oct; 26 (10): 1417-33. Epub 2010 Aug 10

Pearl M, Gomez J, Gregg L, Gailloud P. Endovascular management of vein of Galen aneurysmal malformations. Influence of the normal venous drainage on the choice of a treatment strategy. Childs Nerv Syst. 2010 Oct; 26 (10):1367-79. Epub 2010 Aug 20

Activities & Honors


  • Foundation Scholar Award in Neuroradiology Research, American Society of Neuroradiology, 2013
  • Emerging Women's Leadership Program, 2012
  • Solving Kids' Cancer, Therapeutic Development Initiative Grant Award, 2012
  • Sheikh Zayed RAC Grant Award, Children's Research Institute, 2012
  • Editor-in-Chief, Journal of Pediatric Neuroradiology, 2011
  • Codman and Shurtleff Inc. Fellowship Training Grant, 2009
  • RSNA Roentgen Resident Research Award, 2008
  • Chief resident, George Washington University Hospital, 2007 - 2008
  • Resident-in-Training Scholarship, Society of Interventional Radiology, 2006
  • Research Fellowship, National Institutes of Health, 2001 - 2002
  • Enhanced Research Training Program Grant, National Institutes of Health, 2001
  • Intramural Research Training Award, National Institutes of Health, 1995 - 1996


  • American College of Radiology
  • American Society of Neuroradiology
  • Society of Neurointerventional Surgery

Professional Activities

  • Diplomate, American Board of Radiology
  • Editor-in-Chief, Journal of Pediatric Neuroradiology

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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