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School of Medicine
Michael Aaron Edidin, Ph.D.
Joint Appointment in Medicine
Research Interests: Membrane dynamics and organization in cells
Michael Edidin is a professor of biology at Johns Hopkins University. He is also an adjunct professor of medicine, of materials science in the Whiting School of Engineering and of pathology. His research uses cell biology, biophysics, biochemistry and immunology to study membrane dynamics and organization in cells ranging from lymphocytes to epithelial cells.
His team is currently engaged in investigating the clustering of T cell receptors for the antigen TCR.
Dr. Edidin received his Ph.D. from the University College London, followed by postdoctoral work at both the Weizmann Institute and Harvard Medical School.
He is a fellow of University College London, the American Association for the Advancement of Science and the Biophysical Society. His work has been recognized with a Professional Achievement Award from the University of Chicago Alumni Association in 2009.
- Joint Appointment in Medicine
- Joint Appointment in Pathology
Research & Publications
Dr. Edidin’s laboratory uses cell biology, biophysics—especially fluorescence methods—biochemistry and immunology to study membrane dynamics and organization in cells ranging from lymphocytes to epithelial cells. All of their work on membranes arises from interests in transplantation immunology, especially in the cell biology of class I MHC molecules. They aim to understand the relationship between plasma membrane biophysics and antigen presentation by MHC molecules.
Perica K, De León Medero A, Durai M, Chiu YL, Bieler JG, Sibener L, Niemöller M, Assenmacher M, Richter A, Edidin M, Oelke M, Schneck J. "Nanoscale artificial antigen presenting cells for T cell immunotherapy." Nanomedicine. 2014 Jan;10(1):119-29. doi: 10.1016/j.nano.2013.06.015. Epub 2013 Jul 24.
Lo YC, Edidin MA, Powell JD. "Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles." J Immunol. 2013 Nov 15;191(10):5107-14. doi: 10.4049/jimmunol.1301433. Epub 2013 Oct 4.
Perica K, Bieler JG, Edidin M, Schneck J. "Modulation of MHC binding by lateral association of TCR and coreceptor." Biophys J. 2012 Nov 7;103(9):1890-8. doi: 10.1016/j.bpj.2012.09.011.
Lavi Y, Gov N, Edidin M, Gheber LA. "Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton." Biophys J. 2012 Apr 4;102(7):1543-50. doi: 10.1016/j.bpj.2012.01.042. Epub 2012 Apr 3.
Boyle S, Kolin DL, Bieler JG, Schneck JP, Wiseman PW, Edidin M. "Quantum dot fluorescence characterizes the nanoscale organization of T cell receptors for antigen." Biophys J. 2011 Dec 7;101(11):L57-9. doi: 10.1016/j.bpj.2011.10.028.
Activities & Honors
- Fellow of the Biophysical Society, 2010
- Professional Achievement Award, University of Chicago Alumni Association, 2009
- Fellow, American Association for the Advancement of Science (AAAS), 2006
- Fellow of University College London (England), 2004
- MERIT Award, National Institutes of Health, 1988
- Meyerhoff Fellowship of the Weizmann Institute, 1981
- Cole Medal of the Biophysical Society, 1979