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Andrew Jon Holland, M.A., Ph.D.

Photo of Dr. Andrew Jon Holland, M.A., Ph.D.
  • Associate Professor of Molecular Biology and Genetics

Research Interests

Cell cycle control; Genome instability; Chromosome segregation.

Background

Dr. Andrew J. Holland is an assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine and holds a secondary appointment in Oncology. Dr. Holland's research focuses on the molecular mechanisms that control accurate chromosome distribution and the role of cell division errors in human health and disease.

Dr. Holland received his undergraduate degree from the University of Cambridge, UK. He earned both his Ph.D. and Masters in Research at the University of Manchester, UK. He completed a postdoctoral fellowship at the Ludwig Institute for Cancer Research at the University of California, San Diego. Dr. Holland joined the Hopkins faculty in 2013.

Dr. Holland is a member of the American Society for Cell Biology, the American Association for Cancer Research, and American Association for the Advancement of Science. In 2014 he was selected as a Kimmel Scholar and a Pew-Stewart Scholar. His work recognized in 2016 with the R.R. Bensley Award in Cell biology by the American Association of Anatomists.

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Titles

  • Associate Professor of Molecular Biology and Genetics
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D., University of Manchester (United Kingdom) (2006)
  • M.A., University of Cambridge (United Kingdom) (2002)

Additional Training

Ludwig Institute for Cancer Research, San Diego, CA, 2013

Research & Publications

Research Summary

Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development.

Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.

The Holland Lab is interested in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease.

The lab utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology.

A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis.

Lab Website: Holland Lab

Selected Publications

View all on Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer. Yeow, Z.Y.*, Lambrus, B.G.*, Marlow, R., Zhan, K.H., Durin, M., Evans, L.T., Scott, P.M., Phan, T., Park, E., Ruiz, L.A., Moralli, D., Knight, E.G., Badder, L.M., Novo, D., Haider, S., Green, C.M., Tutt, A.N.J., Lord, C.J., Chapman, J.R.*, Holland, A.J.*. Nature. In Press. (2020)

WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park, E., Scott, P.M., Clutario, K.M., Cassidy, K.B., Zhan, K., Gerber and Holland, A.J. Journal of Cell Biology 219(1). (2019).

Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Mercey, O.*, Levine, M.S.*, LoMastro, G., Rostaing, P., Brotslaw, E., Gomez, V., Kumar, A., Spassky, N., Mitchell, B.J., Meunier, A.* and Holland, A.J.* Nature Cell Biology 21: 1544-52. (2019).

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall. Moyer, T.C. and Holland, A.J. eLIFE 8: e46054. (2019).

Once and only once: mechanisms of centriole duplication and their deregulation in disease. Nigg, E.A., Holland, A.J. Nature Reviews Molecular Cell Biology 19(5): 297-312. (2018).

Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals. Levine, M.S., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, D.C., Lansdorp, P.M., Cleveland, D.W., Lambrechts, D., Foijer, F. and Holland, A.J. Developmental Cell 40(3): 313-22. (2017).

A USP28-53BP1-p53-p21 signaling axis arrests growth following centrosome loss or prolonged mitosis. Lambrus, B.G., Daggubati, V., Uetake, Y., Scott, P.M., Clutario, K.M., Sluder, G., Holland, A.J. Journal of Cell Biology 214:143-153. (2016).

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry, Cellular and Molecular Biology Graduate Program

Activities & Honors

Honors

  • Johns Hopkins Catalyst Award, 2016
  • R.R. Bensley Award in Cell Biology, American Association of Anatomists, 2015
  • Johns Hopkins Discovery Innovation Award, 2015
  • Pew-Stewart Scholar for Cancer Research, 2014
  • Kimmel Scholar, 2014
  • Leukemia and Lymphoma Society senior fellowship, 2011 - 2014
  • Basil O'Connor Starter Scholar Award, March of Dimes, 2014
  • Basil O'Connor Starter Research Award, March of Dimes, 2013
  • EMBO long-term fellowship, 2007 - 2009

Memberships

  • American Association for Cancer Research, 2009
  • American Association for the Advancement of Science, 2013
  • American Society for Cell Biology, 2005
  • American Society for Cell Biology, 2012
    Membership Committee

Professional Activities

  • Associate Chair, Gordon Research Seminar on Cell Growth and Proliferation, 2011

Videos & Media

TomorrowsDiscoveries: When Cell Division Goes Wrong—Dr. Andrew Holland

Lectures and Presentations

  • Inside the Cell
    PhD Course, Portugal (01/01/2011)
    Gulbenkian Science Institute

Recent News Articles and Media Coverage

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