The Biswal lab studies the mechanisms of susceptibility to environmental lung diseases, such as cancer, COPD and asthma. We have identified that transcription factor, Nrf2, is a critical modifier of inflammation which determines susceptibility to these diseases. Translational research focusing on elucidation of pathways and mechanism by which Nrf2 regulates pathogenesis of inflammatory diseases is in progress. These studies are helping in devising novel strategies for intervening cancer and other diseases where inflammation play a key role.
Smoke Exposure Core
Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG, Biswal S. "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth." Mol Cancer Ther. 2010 Feb;9(2):336-346.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. "Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema." Nat Med. 2010 Jul;16(7):767-773.
Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. "Regulation of notch1 signaling by nrf2: implications for tissue regeneration." Sci Signal. 2010;3(130):ra52.
Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA, Corvalan AH, Biswal S, Swisher SG, Bekele BN, Minna JD, Stewart DJ, Wistuba II. "Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features." Clin Cancer Res. 2010 Jul 15;16(14):3743-3753.
Singh U, Kumar A, Sinha R, Manral S, Arora S, Ram S, Mishra RK, Gupta P, Bansal SK, Prasad AK, Biswal S, Parmar VS, Raj HG. "Calreticulin transacetylase catalyzed modification of the TNF-alpha mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates." Chem Biol Interact. 2010 May 14;185(3):263-270.
Singh A, Wu H, Zhang P, Happel C, Ma J, Biswal S. "Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype." Mol Cancer Ther. 2010 Aug;9(8):2365-2376.
Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S. "Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance." Antioxid Redox Signal. 2010 Dec 1;13(11):1627-1637.
Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Dore S. "The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway." J Cereb Blood Flow Metab. 2010 Dec;30(12):1951-1961.
Rangasamy T, Williams MA, Bauer S, Trush MA, Emo J, Georas SN, Biswal S. "Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract." Am J Respir Cell Mol Biol. 2010 Sep;43(3):276-285.
Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S. "Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis." Nucleic Acids Res. 2010 Sep 1;38(17):5718-5734.