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Shanmugasundaram Ganapathy Kanniappan, Ph.D.

Photo of Dr. Shanmugasundaram Ganapathy Kanniappan, Ph.D.

Assistant Professor of Radiology and Radiological Science

Research Interests: Cancer metabolism; cancer immunotherapy; liver fibrosis

Background

Dr. Ganapathy-Kanniappan is an Assistant Professor in the Department of Radiology & Radiological Science of Johns Hopkins University School of Medicine. Dr. Ganapathy-Kanniappan's research interest includes cancer metabolism and altered energy metabolism in liver fibrosis.

Dr. Ganapathy-Kanniappan obtained his Ph.D degree from the University of Madras and underwent postdoctoral training at premier institutes such as National Institute of Immunology (NII), New Delhi and the University of California at Los Angeles (UCLA). After a fellowship in the Department of Medicine/ Hematology division at Johns Hopkins, he joined the Radiology department as a faculty.

Dr. Ganapathy-Kanniappan has several publications in reputed journals and has written many reviews and a book chapter on cancer metabolism and therapeutic opportunities.

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Titles

  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • B.S., University of Madras (India) (1988)
  • Ph.D., University of Madras (India) (1998)

Research & Publications

Research Summary

My primary research interest is to develop effective strategies that can selectively target “altered energy producing pathways” or “metabolic reprogramming” in disease conditions such as cancer and liver fibrosis.

Liver cancer: Our aim is to develop an effective antiglycolytic strategy that can selectively and specifically disrupt tumor metabolism and improve the therapeutic outcome of HCC patients.

Breast cancer: Our goal is to revolutionize treatment regimens by replacing interventions that are challenged by lack of efficacy or increased toxicity”. With my background in cancer metabolism and collaboration with Drs. Bhujwalla and Dr.Wu, we intend to develop a novel framework whereby cancer metabolism could be minimally perturbed to trigger host immune response.

Liver fibrosis: The long term goal is to develop effective therapeutic strategies for liver diseases such as fibrosis/cirrhosis by selective targeting of “energy metabolism” in hepatic stellate cells (HSCs) that exhibit uncontrolled activation.

Selected Publications

View all on Pubmed

Gajendiran P, Vega LI, Itoh K, Sesaki H, Vakili MR, Lavasanifar A, Hong K, Mezey E, Ganapathy-Kanniappan S. Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin. J Cell Mol Med. 2018 Apr;22(4):2210-2219. doi:10.1111/jcmm.13501. Epub 2018 Feb 4. PubMed PMID: 29397578; PubMed Central PMCID: PMC5867155

Ganapathy-Kanniappan S. Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities. Biochim Biophys Acta. Reviews on Cancer. 2017 Aug;1868(1):212-220. doi: 10.1016/j.bbcan.2017.04.002. Epub 2017 Apr 8. Review. PubMed PMID: 28400131

Fu D, Geschwind JF, Karthikeyan S, Miller E, Kunjithapatham R, Wang Z, Ganapathy-Kanniappan S. Metabolic perturbation sensitizes human breast cancer to NK cell-mediated cytotoxicity by increasing the expression of MHC class I chain-related A/B. Oncoimmunology. 2015 Jan 14;4(3):e991228. eCollection 2015 Mar. PubMed PMID: 25949910; PubMed Central PMCID: PMC4404839

BOOK/Monograph Published: Advances in GAPDH Protein Analysis: a Functional and Biochemical Approach. Shanmugasundaram Ganapathy-Kanniappan. Nature Springer Publishers. ISBN: 9811073406; ISBN13: 9789811073403, Pp-115. 2018

eBook: Cancer Metabolism: Molecular Targeting and Implications for Therapy edited by Shanmugasundaram Ganapathy-Kanniappan, Frontiers in Oncology and Frontiers in Pharmacology Publishers, 2017.

Activities & Honors

Honors

  • Concept Award, Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP), USA
  • Pilot Research Grant, Society for Interventional Radiology (SIR) foundation, USA
  • Best Presentation Award, National Symposium on Reproductive Biology and Comparative Endocrinology, India
  • Awarded the prestigious Research Fellowship and Lectureship,, CSIR-UGC, Government of India, 1991

Memberships

  • American Association for Cancer Research

Videos & Media

Lectures and Presentations

  • Targeting Glucose Metabolism: A New Class of Agents against Liver Cancer
    Editorial, 2012 Gastrointestinal Cancers Symposium, San Francisco, CA (01/01/1900)

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