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H. Benjamin Larman, Ph.D.

Photo of Dr. H. Benjamin Larman, Ph.D.

Assistant Professor of Pathology

Background

Dr. Larman earned his B.S. in Engineering Physics and Bioengineering from UC Berkeley in California. He then obtained a Ph.D. from Harvard-MIT's Division of Health Sciences & Technology, which was followed by a postdoctoral fellowship at The Scripps Research Institute. Dr. Larman directs The Laboratory of Precision Immunology, within the Immunology Division of the Pathology Department. 

The Larman laboratory develops and deploys new technologies to study the human immune system and its response to environmental exposures. High throughput DNA sequencing technologies enable the novel, massively parallel molecular assays developed by the group. Examples of these technologies include: phage display of synthetic peptidome libraries for comprehensive, quantitative profiling of antibodies; ribosome display of ORFeome libraries for antigen discovery, protein-protein interaction studies, and drug target identification; ultrasensitive, multiplex RNA quantification techniques to monitor gene expression and detect microbes; and pooled genetic screening to elucidate immune cell function and identify new therapeutic targets. The laboratory uses these and other unbiased approaches to identify new opportunities for monitoring and manipulating immune responses.

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Titles

  • Assistant Professor of Pathology

Departments / Divisions

Education

Degrees

  • B.S., University of California (Berkeley) (California) (2002)
  • Ph.D., Massachusetts Institute of Technology (Massachusetts) (2012)

Research & Publications

Lab Website: Larman Laboratory

Selected Publications

Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MAM, Church GM, Kesari S, LeProust EM, Solimini NL & Elledge SJ, Autoantigen discovery with a synthetic human peptidome, Nat. Biotech. 2011; 29(6): 535-41

Larman HB*, Salajegheh M*, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ & Greenberg SA, "Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis," Ann. Neurol. 2012; 73(3): 408-18

Zhu J*, Larman HB*, Gao G, Somwar R, Zheng W, Laserson U, Ciccia A, Pavlova N, Church GM, Kesari S & Elledge SJ, "Protein interaction discovery using parallel analysis of translated ORFs (PLATO)," Nat. Biotech. 2013; 31(4): 331-4

Larman HB, Scott ER, Wogan M, Oliveira G, Torkamani A & Schultz PG, "Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay," Nucleic Acids Res. 2014; 42(14): 9146-57.

Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung T, Ruxrungtham K, Sanchez J, Brander C, Chung R, OConnor KC, Walker B, Larman HB, & Elledge SJ, Comprehensive serological profiling of human populations using a synthetic human virome, Science. 2015; 384(6239): aaa0698-1-9

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