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Anne Le Thi, H.D.R., M.D., M.S.

Quy Hoa Le Thi, H.D.R., M.D., M.S.

Photo of Dr. Anne Le Thi, H.D.R., M.D., M.S.
  • Associate Professor of Pathology
Female

Research Interests

Cancer metabolism and metabolic aspects of other diseases

Background

Dr. Anne Le studied at the Paris Descartes University, Cochin Port-Royal School of Medicine, in France where she obtained a Habilitation degree, the highest academic qualification a scholar can achieve in Europe. After her clinical training at Henri Poincaré University Hospital, Nancy, in France, Dr. Le started her post-doctoral research fellowship at the Johns Hopkins University School of Medicine in 2007. Since 2011, Dr. Le has been an independent investigator who has yielded a number of contributions to the field of cancer metabolism research demonstrated by her publication record as a pioneer in the field. 

She has published in the best journals, such as Cell Metabolism and the Proceedings of the National Academy of Sciences of the United States of America. Research media, such as Science Daily, American Association for the Advancement of Science (AAAS), Business Insider, ALN® Magazine, among many others, have written about her work. Dr. Le is highly respected and sought after for her strong proficiency in judging the work and ideas of her peers. She is regularly invited to serve on review panels by prestigious organizations such as the National Institutes of Health and the US Department of Defense. She is frequently asked by highly-cited scientific journals to review manuscripts submitted to their journals.

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Titles

  • Associate Professor of Pathology
  • Associate Professor of Oncology

Departments / Divisions

Education

Degrees

  • H.D.R., University Rene Descartes (Paris V) - U.E.R. Cochin-Port Royal - Paris - (France) (2015)
  • M.S., University Rene Descartes (Paris V) - U.E.R. Cochin-Port Royal - Paris - (France) (2004)
  • M.D., Ho Chi Minh City University of Medicine and Pharmacy (Vietnam) (2000)

Research & Publications

Research Summary

The studies in Dr. Anne Le's laboratory primarily focus on cancer metabolism and metabolic aspects of other diseases. Using metabolomics technologies, their studies have led to breakthrough discoveries revealing several characteristic features of the metabolism of cancer (PMID: 22225880).  One of these, the dependence of cancer cells on glutamine metabolism, has translated into clinical trials as a novel therapy for cancer patients. They further tracked the metabolic pathways in the remaining tumor after this novel therapy and identified the best-suited drugs for combined synergistic therapy (PMID: 27559084). Recently, they uncovered a specific role of the neurotransmitter N-Acetyl-Aspartyl-Glutamate (NAAG) for the first time in cancer, suggesting the possible use of NAAG for tumor monitoring. Moreover, NAAG was identified as a glutamate reservoir in cancer (PMID: 30970252).

Lab

You can find out more about Dr. Anne Le's laboratory here.

The Le laboratory consists of a diverse group of researchers led by Dr. Anne Le who is responsible for leading and directing projects. Every member of the lab is passionate about creating innovative solutions for improving the lives of cancer patients. The research conducted in Le lab exploits the altered cellular metabolism found in many cancers for prognostic and therapeutic potential.  

The Le laboratory is also in charge of Metabolomics Program which is part of Institute for Clinical and Translational Research (ICTR) -supported labs.

  • Provides consultation to basic, clinical, and translational research teams regarding the feasibility, design, and costs of projects using metabolomics technologies (including mass spec and NMR-based metabolomics);
  • Provides metabolomics approaches based on specific research projects/questions: ranging from simple assays to high-throughput approaches such as global metabolic profiling and stable isotope-13C, 15N-labeled on a wide variety of sample types;
  • Provides extensive data analysis and suggests options for subsequent steps towards clinical implementation.

Examples of Metabolomics-Based Discovery of Metabolic Aspects of Cancer and Other Diseases:

Lab Website: Le Cancer Metabolism Research Laboratory

Technology Expertise Keywords

Cancer metabolism and metabolic aspects of other diseases- Metabolomics technologies

Selected Publications

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Rep. 2019 Apr 9;27(2):491-501. PMID: 30970252. Selected Publication in which Dr. Le is Corresponding author.

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Aug 24. PMID: 27559084. Selected Publication in which Dr. Le is Corresponding author.

Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12486–12491. PMID: 25114222. Selected Publication in which Dr. Le is Corresponding author.

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21. PMID: 22225880. Selected Publication in which Dr. Le is Corresponding author.

Glucose-independent Glutamine-driven TCA Cycle in Cancer Cells. Glutamine in Health and Disease. Glutamine in Clinical Nutrition, Nutrition and Health, DOI 10.1007/978-1-4939-1932-1_6. Selected Publication in which Dr. Le is Corresponding author.

Contact for Research Inquiries

Johns Hopkins University School of Medicine
1550 Orleans Street
Cancer Research Building-2, Lab: Suite 216; Office: Suite 303
Baltimore, MD 21231 map

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Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Pathobiology

Courses and Syllabi

  • Pathobiology of Cancer Course, Graduate Program in Pathobiology
    Classroom Instruction
  • The Translational Intersession Course on Metabolism for 3rd and 4th year Medical Students
    Classroom Instruction
  • Pathology and Disease Mechanisms Course, Graduate Program in Pathobiology
    Seminars

Videos & Media

Recent News Articles and Media Coverage

Dr Anne Le and her team in the cancer metabolism lab explains their research finding chemical ‘messengers’ responsible for #cancer progression.  Twitter @HopkinsKimmel (April 29, 2019)

This neurotransmitter helps aggressive tumors spread, Medical News Today (April 26, 2019)

Hopkins researchers ID neurotransmitter that helps cancers progress, EurekAlert (April 24, 2019)

Johns Hopkins Scientists Track Metabolic Pathways to Find Drug Combinations for Pancreatic Cancer, Johns Hopkins Medicine News

Nanoparticle/Diabetes Drug Combo Kills Mouse Pancreatic Cancer Cells, ALN® Magazine

Cancer cells feed on sugar-free diet, ScienceDaily

Students’ global health projects honored at Rice 360° competition, Rice OEDK

A small Boston biotech is at the heart of a groundbreaking approach to tackling cancer, Business Insider (May 21, 2017)

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